DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	694	Identity:	179/694 - (25%)
Similarity:	271/694 - (39%)	Gaps:	171/694 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 VSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTS 573
            :.|::.||:..|      :|:...:|.|:     :::.|...|.:.:       ...|:.|:..:
Mouse     9 LELLVIRNYGPE------VWEDIKKEAQL-----DEEGQFLVRIIYD-------DSKTYDLVAAA 55

  Fly   574 QVSLSSNPD--------------ADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKL 624
            ...|:.|..              .:..|.||...:|                 ...||..:.|
Mouse    56 SKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLG-----------------SNVREFLQNL-- 101

  Fly   625 LRDARHDNICAFIGACTDPPNIC---------IISEYCTRGSLKDILENEDVKLDNMFIASMVAD 680
              ||.||::.........|...|         |:..|..|..|:||:         :.|...||.
Mouse   102 --DALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIV---------IGIIKTVAQ 155

  Fly   681 IIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDF--GLFAFKQ-GIEDSST----------- 731
            .|.|. .:....|:.....|.....:......|..||  .|..|:: |.::|..
Mouse   156 QIHGT-EIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPF 219

  Fly   732 ----DMQHMSAKCLKLLYRAPELLRQGPSSL--VMGTQRG--DAYSFGIL--LYEMHVRRGPFGE 786
                |...:..:|...:||....|:.|..||  |....|.  |....|||  :..:.|.|...|.
Mouse   220 HIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGL 284

  Fly   787 TGLTPMQCLQKV---------LQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKT 842
            ..:..::|..::         |:.|....|...|:     .|.|               .|....
Mouse   285 LDVEKLECEDELTGAEISCLRLKGQMIYLPEADSI-----LFLC---------------SPSVMN 329

  Fly   843 IRTKLR--------PLRKGMRPNIFDNMMAMME-KYANNLEALVDDRTDQLQ-------EEKKKT 891
            :....|        ||....|..:........| |....||.|    ||:||       :|||||
Mouse   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL----TDRLQLTLRALEDEKKKT 390

  Fly   892 DALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECT----PLQVVDFLNDLYT 952
            |.||:.:||..||::|:....|..:.|:.|:|.||.||||.|..::..    .:::|:.||||||
Mouse   391 DTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYT 455

  Fly   953 CFDSIIGHYD---VYKVETIGDAYMVVSGLP---LRNGDLHAAEIATMSLHLLSAVSEFKIRHRP 1011
            .||::.....   ||||||:||.||.|||||   :.    ||..|..::|.::....:.::   .
Mouse   456 RFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIH----HARSICHLALDMMEIAGQVQV---D 513

  Fly  1012 TNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCS---WQC---RQLL 1070
            ...:.:.||||:|.|..||:|.:||||||||:|||..||.|::|...||:.|   ::|   .:..
Mouse   514 GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578

  Fly  1071 DRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQ 1114
            |.|  :|...||.:|||||.:....|.|.. :...|..|.|..:
Mouse   579 DPL--FHLEHRGPVSMKGKKEPMQVWFLSR-KNTGTEETNEEDE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	63/346 (18%)
		TyrKc	597..847	CDD:197581	54/291 (19%)
		HNOBA	<862..907	CDD:285003	21/52 (40%)
		CYCc	886..1078	CDD:214485	82/207 (40%)
		Guanylate_cyc	913..1099	CDD:278633	78/201 (39%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572	37/205 (18%)
		HNOBA	207..406	CDD:311573	50/222 (23%)
		Guanylate_cyc	412..605	CDD:306677	78/201 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810