DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_058786.2	Gene:	Gucy1a1 / 497757	RGDID:	68436	Length:	690	Species:	Rattus norvegicus

Alignment Length:	238	Identity:	106/238 - (44%)
Similarity:	142/238 - (59%)	Gaps:	9/238 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   849 PLRKGMRPNIFDNMMAM----MEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKK 909
            |:...:|..:.....|.    ::|....|:|.::.....|:||||||..||..:.|..||.||.:
  Rat   403 PIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKKTVDLLCSIFPSEVAQQLWQ 467

  Fly   910 GHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYM 974
            |..|..:.:.:|::.|||||||||:.::|:||||:..||.|||.||...|..||||||||||||.
  Rat   468 GQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYC 532

  Fly   975 VVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRH-RPTNRLLLRIGIHSGPVCAGVVGLKMPRY 1038
            |..||. |..|.||.:||.|:|.::...:|....| .|   :.:|||:|||.|.|||||:|||||
  Rat   533 VAGGLH-RESDTHAVQIALMALKMMELSNEVMSPHGEP---IKMRIGLHSGSVFAGVVGVKMPRY 593

  Fly  1039 CLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAER 1081
            ||||:.|..|::.||..||.||:.|....:||....|:.|..|
  Rat   594 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	1/3 (33%)
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	16/48 (33%)
		CYCc	886..1078	CDD:214485	97/192 (51%)
		Guanylate_cyc	913..1099	CDD:278633	85/170 (50%)
Gucy1a1	NP_058786.2	HNOB	<111..234	CDD:285002
		HNOBA	276..465	CDD:285003	18/61 (30%)
		CYCc	444..633	CDD:214485	97/192 (51%)
		Guanylate_cyc	471..642	CDD:278633	85/170 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810