DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and NPR1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_000897.3	Gene:	NPR1 / 4881	HGNCID:	7943	Length:	1061	Species:	Homo sapiens

Alignment Length:	1147	Identity:	425/1147 - (37%)
Similarity:	600/1147 - (52%)	Gaps:	174/1147 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRP-GNLDYNRPGLTISGAISLAVEEVNAGR 80
            ||.||||||        |.:|.     |.||.:...| .|..|......:..|:.||:.:|.|..
Human    19 LLPPLLLLL--------RGSHA-----GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARP 70

  Fly    81 LRDRGHSLQFVVAETYGEEVVSI-RQTAA-------LWTQQVAAYIGPQETCVHE----GRMAAA 133
            ....|.:::.|:..:  |..:.: ..|||       .|....|.::||  .||:.    ||..|.
Human    71 DLLPGWTVRTVLGSS--ENALGVCSDTAAPLAAVDLKWEHNPAVFLGP--GCVYAAAPVGRFTAH 131

  Fly   134 FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNW-TQVSFLYLDDASGQYQP 197
            :.:|:::..........|.::....|..|...::...|.||.....| .|...||      .|:|
Human   132 WRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLY------AYRP 190

  Fly   198 VAETILSTLTDA-GVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVS 261
            ..|.....|.:. .:.:|| |...|:.|..|.::.                 |.||   ..|:.:
Human   191 GDEEHCFFLVEGLFMRVRD-RLNITVDHLEFAEDD-----------------LSHY---TRLLRT 234

  Fly   262 LQRRG----ILSKGDYF--------VVGIDIEQY----------------DPAKPEKYLRGLLLE 298
            :.|:|    |.|..|.|        ..|:..|.|                .||....:.||   :
Human   235 MPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERG---D 296

  Fly   299 DVEPLAVQAFQSYLGIVPTASVSFATFANEVN----------KYMERPPFNFPNPLGPFGGVKQI 353
            ..:..|.||||         :....|:.:..|          |::....|||....|      .:
Human   297 GQDVSARQAFQ---------AAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDG------LV 346

  Fly   354 SAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTV 418
            :...|..:|.:.||.:|:.|.|..||...:|..|...:....::...|| :.||.:||...:::
Human   347 NTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGY-LKIDSSGDRETDFS- 409

  Fly   419 LARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFG 483
            |......||..:.||...  ||    :..|.::|.          ..::|..|..|...|:|||.
Human   410 LWDMDPENGAFRVVLNYN--GT----SQELVAVSG----------RKLNWPLGYPPPDIPKCGFD 458

  Fly   484 GE--KCVN---YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENERE 543
            .|  .|..   .|.|:.|.:...:||.:.:||..:||..:.|:||.|.||::.:.:|:....||.
Human   459 NEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERH 523

  Fly   544 QQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVR 608
            .:|......|..               |.|........:..|:   :|.....|||.|.|:|:|.
Human   524 LRSAGSRLTLSG---------------RGSNYGSLLTTEGQFQ---VFAKTAYYKGNLVAVKRVN 570

  Fly   609 KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMF 673
            :|.:::||::..|||.:||.:::::..|:|||||||||||::|||.||||:||||||.:.||.||
Human   571 RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMF 635

  Fly   674 IASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSA 738
            ..|:..||::|:::||:..|..||.|.:|||:||.|:|:|:||:||.:|:    |...:..|  .
Human   636 RYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DLDPEQGH--T 694

  Fly   739 KCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETG--LTPMQCLQKVL-- 799
            ...|.|:.||||||.. |..|.|:|.||.|||||:|.|:.:|.|.|...|  |:|.:.:::|.
Human   695 VYAKKLWTAPELLRMA-SPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRG 758

  Fly   800 -QPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMM 863
             ||     |:|||| .|::..:.:...::.||||.|::||.|:.||..||...:....||.||::
Human   759 EQP-----PFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLL 817

  Fly   864 AMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDI 928
            :.||:||||||.||::||....|||:|.:|||:::||..||:|||:|..|..|.::.|:||||||
Human   818 SRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDI 882

  Fly   929 VGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIAT 993
            |||||:|||.||:|||..|||||||||::|.::|||||||||||||||||||:|||.|||.|:|.
Human   883 VGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVAR 947

  Fly   994 MSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPL 1058
            |:|.||.||..|:|||||..:|.||||||:||||||||||||||||||||||||||||||:|..|
Human   948 MALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012

  Fly  1059 KIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGE 1100
            |||.|.:.:.:|:..||:....||.:.|||||..||||||||
Human  1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	99/452 (22%)
		ANF_receptor	67..416	CDD:279440	87/400 (22%)
		PK_GC-A_B	570..853	CDD:270944	121/287 (42%)
		TyrKc	597..847	CDD:197581	115/254 (45%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	132/191 (69%)
		Guanylate_cyc	913..1099	CDD:278633	129/185 (70%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380	100/473 (21%)
		ANF_receptor	54..414	CDD:279440	88/410 (21%)
		PK_GC-A_B	534..807	CDD:270944	121/303 (40%)
		TyrKc	547..801	CDD:197581	117/269 (43%)
		HNOBA	<816..861	CDD:285003	23/44 (52%)
		CYCc	840..1032	CDD:214485	132/191 (69%)
		Guanylate_cyc	867..1053	CDD:278633	129/185 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720