DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Ac78C

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster

Alignment Length:	845	Identity:	183/845 - (21%)
Similarity:	303/845 - (35%)	Gaps:	250/845 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 LGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTR--PAAAPR-CGFGGEKCVNYTGEI 494
            |...|...|..::|..|...:..|.:           |||.  .:|||| .|...|:.|     :
  Fly    40 LSATPSSAFSLQHSRGSDTKEEAPPE-----------GGTMGGKSAAPREEGEPDERVV-----L 88

  Fly   495 SAAIAGGALLLLSLVSLVLYRNWRYE-----QELDSL------LWKIDFREVQIH---------- 538
            ..|:..||:.|..:..|.|..:...|     :|:|.|      ....|..::.::
  Fly    89 RRAVDKGAIALAQIDDLKLEGDDDDEAVVNGEEVDGLGLSNPAAQTTDDEQITVNGTGAAATSSV 153

  Fly   539 -----ENEREQQSQKQTRHLLNHLPRRLPPQSTH----------PLIRTSQVSLSSNPDADFRYT 588
                 .:|::..|.......::.:| |||.....          |.:|.|..|:.||    .|..
  Fly   154 AADAASSEQDAASTAMATPDMSKIP-RLPGDGAQMEDNGSGDLPPSLRASTTSILSN----LRKK 213

  Fly   589 TIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYC 653
            ....|:   :|.:.....:|.:||.|. |.|   :.....|....|:..|      |.....:..
  Fly   214 QQGGPL---RGGVAKQTPLRVQSVRIV-EAK---RAYGPKRRTESCSIFG------NSNFEHDLE 265

  Fly   654 TRGSLKDILENEDVKLDN-MFIASMVADIIRGVI----------------YLHDSPIRFHGALCT 701
            :..||..|.......|:| |:.|....::::|::                ||..:..:...:|..
  Fly   266 SGNSLASIPGQSQRPLNNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLII 330

  Fly   702 SNCLVD--------SRWVVKLTDFGLFAFKQGIE-DSSTDMQ----------------------- 734
            .| :||        ..|:::.::.|      .|| |..|.|.
  Fly   331 VN-VVDFVLKIVLAFVWIMRRSELG------PIESDDGTSMATAITWSVCCGIANMAICFLGYWR 388

  Fly   735 -------HMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPM 792
                   |.:|.|..:|:.....:.||.         |.|....::.|.:.|...|:....|...
  Fly   389 CFANNYLHWAAVCTWVLFNIQGFVGQGV---------GFADREYLVWYILFVIFVPYAMLPLPLK 444

  Fly   793 QC----------------LQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFK 841
            .|                :.|:...:..:||            :||   |.:.:|       :|
  Fly   445 WCVVGGTITASCHLAVITIIKLQHGEATINP------------ECV---LFQIFA-------NF- 486

  Fly   842 TIRTKLRPLRKGMRPNIFDNMMAMMEKYANNL-EALVDDRTDQLQEEKK-------KTDALLHEM 898
            .:.|.:             |:..|..||..:. :.|....|.:..|.||       :|..||..:
  Fly   487 ILYTAI-------------NVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSI 538

  Fly   899 LPRCVADQLK----KGHKVDPE-----------HYEQVSIYFSDIVGFTAMSAECTPLQVVDFLN 948
            ||..|.:|::    ||  .||.           ..:.|||.|:||.|||.::::.:..|:|..||
  Fly   539 LPNIVNNQIRSEMYKG--TDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILN 601

  Fly   949 DLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDL---HAAEIATMSLHLLSAVSEFKIR-H 1009
            ||:..||.|.......:|:.:||.|..||.....|...   ||.......||::.|:.:.::. |
  Fly   602 DLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTH 666

  Fly  1010 RPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRL- 1073
            ...|   :|||||||.|..||:|.|...:.::.:.|..|:.|||.|:|.::|.|....:.|:..
  Fly   667 VDLN---MRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAY 728

  Fly  1074 ------GGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQA 1132
                  ||.......::::|      || |:...|..|.:|      |.|:|: :..:.|::..|
  Fly   729 EVEPGNGGCRDNHLKMLNVK------TY-LIKRTEPLRPKR------RFGTRS-SAHLAGSVATA 779

Fly 1133 1132
Fly 780 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	2/7 (29%)
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	61/354 (17%)
		TyrKc	597..847	CDD:197581	54/321 (17%)
		HNOBA	<862..907	CDD:285003	14/52 (27%)
		CYCc	886..1078	CDD:214485	70/224 (31%)
		Guanylate_cyc	913..1099	CDD:278633	62/207 (30%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	53/314 (17%)
		CYCc	526..729	CDD:214485	65/207 (31%)
		Guanylate_cyc	566..753	CDD:278633	60/196 (31%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810