DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and CG42637

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1283	Identity:	507/1283 - (39%)
Similarity:	710/1283 - (55%)	Gaps:	178/1283 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDR 84
            |..|||.|.........|..|.|:|||||   ..|:|. .|.||.||||:::|::|||.......
  Fly     5 PFNLLLLLSVAVRDCSNHRTVLTVGYLTA---LTGDLK-TRQGLAISGALTMALDEVNKDPNLLP 65

  Fly    85 GHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPS 149
            ...|.....:|.|:.|::.:....:....:|...||:..|..|..::.:.|:|||||.|.....|
  Fly    66 NVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAEYRAS 130

  Fly   150 NKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIR 214
               ..||||||.|||||:.||::|||..:.|.:.|.||.|    .:.|||:.:....|...::|.
  Fly   131 ---AIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYED----VWSPVADLLKDQATKRNMTIN 188

  Fly   215 DIRTWNTIYHHGFMDNPFEA---------------LVEQTYANTRIYLILGHYYEHVGLMVSLQR 264
                    :...|:||..:.               ||:.|...||||:.||.....|..|.|::.
  Fly   189 --------HKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMET 245

  Fly   265 RGILSKGDYFVVGIDIEQYDPAKPEKYLRGL----------LLEDVEPLAVQAFQSYLGIVPT-A 318
            .|:.::|:|.|:.:|:..|...:.|||||.:          ..|:...:|    :|.|.:..| .
  Fly   246 AGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMA----RSLLVVASTPP 306

  Fly   319 SVSFATFANEVNKYMERPPFNFPNPL----GPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGG 379
            :..:..|..:|.||..:||||...|.    ..|.  |.||..||||||:|.|||.|:.::|....
  Fly   307 TKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFS--KFISIYAAYLYDSVKLYAWAVDKMLREET 369

  Fly   380 R----------PRNGSAIV-AAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVR--NGRNQT 431
            |          ..||:.:: ..||...|.|..|..:.||:.||:.||::|||....:  |..|..
  Fly   370 RVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMP 434

  Fly   432 V-LGLRPVGTFIHRNSSLSSISKALPHQNLKLFS-PIDW-VGGTRPAAAPRCGFGGEKC----VN 489
            . ..:.||..| |:...         |...||.: .||| .||.:||..|.|||..|.|    .:
  Fly   435 CNYHMVPVAYF-HQGEE---------HPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTH 489

  Fly   490 YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLL 554
            ||..::|.:.|..|....::::.:||.|:.|.|::.||||||
  Fly   490 YTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKID----------------------- 531

  Fly   555 NHLPRRLPPQSTHPLIRT-SQVSLSSNPDADFRYTTIF-TPIGLYKGQLYAIKKV---RKKSVDI 614
               |..:...|.:.::.: |:|||.|......|:|..| |..|..:|.:..||::   ||:  ||
  Fly   532 ---PNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKR--DI 591

  Fly   615 TREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVA 679
            :||:.||::|||:.|||||.:||||..:|..|.::::||.:|||.||:||||:|||::||||::.
  Fly   592 SREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIH 656

  Fly   680 DIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSST-DMQHMSAKCLKL 743
            |:|:|:||:|:|.:.:||.|.:|||:|.|||::::|||||...:|..|:.|. :.||...:
  Fly   657 DLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQ---- 717

  Fly   744 LYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKV----LQPQDY 804
            |:|||||||    :.:.|:|:||.|:|.|::||:..|:||||:....|.:.:..|    |:.:|
  Fly   718 LWRAPELLR----NHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGED- 777

  Fly   805 LNPYRPSLQPL---ETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMM 866
              |:||.::.:   |:..|.|..|:|:||||.||:||:|..||.:|:.:|.|...||.|.||.||
  Fly   778 --PFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMM 840

  Fly   867 EKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGF 931
            ||||||||.:|.:||..|.|||.||:.|||.|||:.||::|..|..|:|..|:.|:|||||||||
  Fly   841 EKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGF 905

  Fly   932 TAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSL 996
            ||||||.||||||:|||||||.||.||..||||||||||||||||||||::|||.||.|||:|:|
  Fly   906 TAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMAL 970

  Fly   997 HLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIH 1061
            .||.||.:.:|.|||...|.||||:|:|||.||||||.|||||||||||||||||||:|..||||
  Fly   971 ELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIH 1035

  Fly  1062 CSWQCRQLLDRLGGYHFAE-RGVISMKGKGDQRTYWLLGEDEEARTRRTYER--------SQRRG 1117
            .|.:|:..||:|||.:..| ||:::||||||..|:||.|.:|.|..::..:.        |:.|.
  Fly  1036 ISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRK 1100

  Fly  1118 SRALN-----------KFI------QGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLESPK 1165
            |..||           .|.      |.|:.:|.:..:.|.::.|:::.  ||....|....|.|.
  Fly  1101 SPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRES--PRMVSKRDRDRERPP 1163

  Fly  1166 -----KLRFAAGSLLEHHR------YHSD--EALLEVDSYTGLRRSSG 1200
                 ...|..|:|||..:      .||:  |...::|..:|....||
  Fly  1164 INGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDGGSGGVSGSG 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	139/443 (31%)
		ANF_receptor	67..416	CDD:279440	118/389 (30%)
		PK_GC-A_B	570..853	CDD:270944	127/295 (43%)
		TyrKc	597..847	CDD:197581	115/260 (44%)
		HNOBA	<862..907	CDD:285003	29/44 (66%)
		CYCc	886..1078	CDD:214485	135/191 (71%)
		Guanylate_cyc	913..1099	CDD:278633	132/186 (71%)
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	139/443 (31%)
		ANF_receptor	48..412	CDD:279440	115/384 (30%)
		PK_GC-A_B	543..827	CDD:270944	127/296 (43%)
		HNOBA	<835..881	CDD:285003	29/45 (64%)
		CYCc	860..1052	CDD:214485	135/191 (71%)
		Guanylate_cyc	887..1074	CDD:278633	132/186 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I3716
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28900
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14798
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6487
	8	7.730