DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and CG3216

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	1181	Identity:	405/1181 - (34%)
Similarity:	584/1181 - (49%)	Gaps:	245/1181 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VFTLGYLTASQ-RRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQF------------- 90
            |:.:|.|.||. ..|.:|:...|      |:.||::|:|...|:.  |::..
  Fly    88 VYNVGVLMASHLDSPFDLERCGP------AVDLALDEINKVFLKP--HNITLLKKKGSYPSCSGA 144

  Fly    91 ----VVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHE----GRMAAAFNLPMISYYCTHRD 147
                :.|:.|.::             .|.|:|||  .|...    .|:||.:|.|:|: ....:.
  Fly   145 RAPGLAADMYFQD-------------DVIAFIGP--ACAFALEPVARLAAYWNKPIIT-GMGDQP 193

  Fly   148 PS---------------------------NKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSF 185
            ||                           :|:.:||..|......::.....:::..|||..|:.
  Fly   194 PSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVAL 258

  Fly   186 LYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTI---YHHGFMDNPFEALV-------EQTY 240
            |                        |...::.:| |:   ..:|.......:.|       |:.|
  Fly   259 L------------------------VDRSELFSW-TVGKNLEYGLRQEGLLSFVKELNGNEEEVY 298

  Fly   241 ANTRIYLILGHYYEHVGLMVSLQRRGIL-------------SKGDYFVVGIDIEQYDPAKPEKYL 292
            .|   ||.....|..|   |.|..||:|             :.|::..:.::|.|      .:|.
  Fly   299 EN---YLKDASMYARV---VILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQ------SEYW 351

  Fly   293 --RGLLLEDV-EPLAVQAFQSYL--GIVPTASVSFATFANEVNK---YMERPPFNFPNPLGPFGG 349
              :|..::|. :..|.:|:::.|  .::...|..|..||:.|.:   |    .:|:     .||.
  Fly   352 GDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALY----DYNY-----TFGE 407

  Fly   350 VKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAG 414
            .::::......||.|:|...||.|.|..||..|:|..|...:....:....| ||.||:|||...
  Fly   408 GEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITG-HVRIDDNGDRDA 471

  Fly   415 NYTVLARGSVRNGRNQTVL---GLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTR--P 474
            :|::|....: ||:...|.   |:..|.:.:|...                   |.|.||..  |
  Fly   472 DYSILDLDPI-NGKFSVVAHYSGVHKVYSAVHGKK-------------------IHWPGGREEPP 516

  Fly   475 AAAPRCGFGGEK--CVNYTGEISAAIAGGALLLLSLVSLV---LYRNWRYEQELDSLLWKIDFRE 534
            ...|.|||.|..  ||.....|..::. |.||.|.||.||   |.:..:..:||:::.|::...:
  Fly   517 PDVPPCGFLGNSTDCVGNFSTIMYSVF-GLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDD 580

  Fly   535 VQIH----------------ENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDA 583
            |.|.                ||...||....:.                   |.|..|.:|.|
  Fly   581 VLIEMGGMFGSKGGLQRLDVENISLQQFGIHSG-------------------RASIASFTSLP-- 624

  Fly   584 DFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTD--PPNI 646
                ..::|.||.:||:..|||||..|.||:|.::..|:|..||..|:|...|:|||.|  .|.:
  Fly   625 ----PQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTV 685

  Fly   647 CIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWV 711
            .|::|||:||||||:||||.::||..|..|::.||::|:.|||:|.:..||.|.:.|||:|.|:|
  Fly   686 LILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFV 750

  Fly   712 VKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMG----TQRGDAYSFGI 772
            :|::||||...     .:.:|........||||:.|||||   |.:.:.|    |||||.|||||
  Fly   751 LKISDFGLRTL-----TTPSDFVRDQNYYLKLLWIAPELL---PLTTIPGCCPATQRGDVYSFGI 807

  Fly   773 LLYEMHVRRGPFGET--GLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPE 835
            :|.|:..|.||:.|.  .:.....|.||.|    .|.:||.::..|...|.: |.:.:|||:..|
  Fly   808 ILEEIVNRGGPYQEARQQMDVHTILHKVRQ----CNGFRPLIRERECPPDLL-ELMEKCWADNQE 867

  Fly   836 DRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLP 900
            :||.|.|||:.:|.:.||...|:.|:::..||:||||||:||:::|.||..||::|:.||:::||
  Fly   868 ERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILP 932

  Fly   901 RCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYK 965
            |.||.||..|..|:||.:..|:||||||||||.:.|..:|:.||:||||||:.||.|||.|||||
  Fly   933 RPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYK 997

  Fly   966 VETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGV 1030
            ||||||||:||||||..|||.||.|||.|:|.:|.|||.|.:||:|..::.:|||:|||.|||||
  Fly   998 VETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAGV 1062

  Fly  1031 VGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTY 1095
            ||.|||.||||||||||||||||:|.|.|||.|...:.:||:.|.:...:||.:.:||||...||
  Fly  1063 VGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTTY 1127

  Fly  1096 WLLGEDE-EAR 1105
            ||....| |||
  Fly  1128 WLNSTSEGEAR 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	102/482 (21%)
		ANF_receptor	67..416	CDD:279440	88/427 (21%)
		PK_GC-A_B	570..853	CDD:270944	119/290 (41%)
		TyrKc	597..847	CDD:197581	110/257 (43%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	120/191 (63%)
		Guanylate_cyc	913..1099	CDD:278633	117/185 (63%)
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	101/477 (21%)
		ANF_receptor	107..479	CDD:279440	91/442 (21%)
		PKc_like	616..885	CDD:304357	118/287 (41%)
		TyrKc	627..877	CDD:197581	112/262 (43%)
		HNOBA	<882..939	CDD:285003	27/56 (48%)
		CYCc	918..1109	CDD:214485	120/190 (63%)
		Guanylate_cyc	945..1131	CDD:278633	117/185 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.820