DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Gyc32E

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	465/1140 - (40%)
Similarity:	662/1140 - (58%)	Gaps:	114/1140 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PCPAPAGNYHSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGN-------LDYNRPG 62
            ||.:.|.       ...:|:|.||......|     ...|...:|.||..:       .:|::..
  Fly     4 PCASAAA-------FSCILVLLLLGCQRSNP-----LAAGATVSSMRRLTDTINIGFLAEYSQMR 56

  Fly    63 LTISGAISLAVEEVN-----------AGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAA 116
            :|: |.:.||:|:||           |.:..|.||.:.       ...|..:|....:....|.|
  Fly    57 VTL-GGLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMS-------AYRVKPLRAMTQMREAGVTA 113

  Fly   117 YIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWT 181
            :|||.|:|..|..:|:|:|.||:|:.|:....|||:.|.|||||..|.:::||||::||.||:|.
  Fly   114 FIGPDESCTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWN 178

  Fly   182 QVSF------LYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTY 240
            :.|.      ::..|.:...|.:||....|::........|.|..|:       :..:.::|:||
  Fly   179 KFSIVVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTL-------SQIDKIIEETY 236

  Fly   241 ANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKP---------EKYLRGLL 296
            |.||||:.:|.:...|..:..||.|.:|..|||.||.:|.|.||..:.         :.|:|
  Fly   237 ATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIR--- 298

  Fly   297 LEDVEPLAVQAFQSYLGIVPT--ASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAY 359
            .|..:.|...:|:|.:.|..|  .:.......:::..|..:.||..|.....|..: .:.....:
  Fly   299 KEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNI-SVPIYGLH 362

  Fly   360 LYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLA-RGS 423
            |||:|.:|.:|:.|||..||...:|:.:::.|....|.|..|:.||||.||||.|||||:. :..
  Fly   363 LYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQND 427

  Fly   424 VRNGR---NQTVLGLRPVGTFIHRNSSLSSISKALPH-QNLKLFSPIDWVGGTRPAAAPRCGFGG 484
            |.:|.   :...:.::|||.|.:..:|:      :|. :.:|...||.|:.|..|.|.|.|||.|
  Fly   428 VGSGASIGSLAKMSMQPVGFFAYDKNSV------IPEFRYIKNDRPIQWLNGRPPLAEPLCGFHG 486

  Fly   485 EKCVNYTGEISAAIAGGALLLLSLVSL-VLYRNWRYEQELDSLLWKIDFREVQ-IHENEREQQSQ 547
            |.|.....:....::|....|:.:|:: :|.:::||||.|..||||:|.::|. |:..|....:.
  Fly   487 ELCPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTN 551

  Fly   548 KQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSV 612
            |                :...:.|.| :.:...|:     ...||.|.|::|.:.|:||:.||||
  Fly   552 K----------------NIFQICRQS-ILVVGEPN-----KRSFTNIALFRGNIVAMKKIHKKSV 594

  Fly   613 DITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASM 677
            ||||.::|||||:|:.||:||..||||.||..::.|.:.||.||||:|:|.|||:.||:|||:|:
  Fly   595 DITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSL 659

  Fly   678 VADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIED-SSTDMQHMSAKCL 741
            |:||::|:||||||.|..||.|.:||||:|||||.:::||||...|.|.|: :.::::...|.|:
  Fly   660 VSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCM 724

  Fly   742 KLLYRAPELLRQG--PSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDY 804
                 ||||||..  |.   .|:|:||.||||||||||..|:||:|:|..:..:.:|.|..|:..
  Fly   725 -----APELLRDAYRPG---RGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEML 781

  Fly   805 LN-PYRPSLQPLETAF-DCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMME 867
            .: .:||:|....... |.:.:||.:||.|.||.|||.:.:|..|:.|:.|::|||||||:::||
  Fly   782 QHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIME 846

  Fly   868 KYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFT 932
            |||.|||.||.:||:.|.|||||||.||::||||.||:.||:|..|:.|.::.|:|.||||||||
  Fly   847 KYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFT 911

  Fly   933 AMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLH 997
            .:....||.:||:.|||.|||.||||.:|||||||||||||||||||||:||..||.|||:::||
  Fly   912 ELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALH 976

  Fly   998 LLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHC 1062
            ||..|...||||:||..:.||||:||||..|||||.||||||||||||||||||||:|..::||.
  Fly   977 LLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHI 1041

  Fly  1063 SWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWL 1097
            |....|||..:|.|...|||:.|:|||||.|||||
  Fly  1042 SEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	131/438 (30%)
		ANF_receptor	67..416	CDD:279440	116/376 (31%)
		PK_GC-A_B	570..853	CDD:270944	131/287 (46%)
		TyrKc	597..847	CDD:197581	122/254 (48%)
		HNOBA	<862..907	CDD:285003	29/44 (66%)
		CYCc	886..1078	CDD:214485	125/191 (65%)
		Guanylate_cyc	913..1099	CDD:278633	121/185 (65%)
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	127/422 (30%)
		ANF_receptor	59..427	CDD:279440	120/386 (31%)
		PHA02988	534..826	CDD:165291	134/321 (42%)
		PK_GC-A_B	550..832	CDD:270944	132/311 (42%)
		HNOBA	<847..886	CDD:285003	26/38 (68%)
		CYCc	865..1057	CDD:214485	125/191 (65%)
		Guanylate_cyc	892..1076	CDD:278633	119/183 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I3716
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14798
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6487
	8	7.820