Protein Alignment CG10738 and GUCY2F

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1092
• Identity: 361/1092 - (33%)
• Similarity: 553/1092 - (50%)
• Gaps: 162/1092 - (14%)

  Fly    68 AISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWT--QQVAAYIGPQET--CVHEG 128
            |..||:|.:|.....|..:|.::|:   ..|:..:.|..::..:  |..:.:|||...  |....
Human    75 AARLAIERINRDPSFDLSYSFEYVI---LNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAAS 136

  Fly   129 RMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASG 193
            .:..:::..:.|:.|.:.:..||..:|||:||.|...::   :|.::..|.|.....:..|:  .
Human   137 LLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDE--D 196

  Fly   194 QYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGL 258
            .:...|..:.|.|...|:.:..:.|      .|.........:::.:...||.:|:  ...|..|
Human   197 IWVHTANRVASALRSHGLPVGVVLT------TGQDSQSMRKALQRIHQADRIRIII--MCMHSAL 253

  Fly   259 MVSLQRRGIL--------SKGDYFVVGIDIEQYD-PAK--PEKYLRGLLLEDVEPLAVQAFQSYL 312
            :....:..:|        :.|.|..|..|...|. |.|  |.:.||.      .|...:|:.:.|
Human   254 IGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN------NPKLREAYDAVL 312

  Fly   313 GI-VPTASVSF------ATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKA 370
            .| |.:...:|      |....|:.:.:|   |:..:||  ||.:          |::::..|:|
Human   313 TITVESQEKTFYQAFTEAAARGEIPEKLE---FDQVSPL--FGTI----------YNSIYFIAQA 362

  Fly   371 LMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYH--VYIDENGDAAGNYTVLARGSVRNGRNQTVL 433
            :...:...|:.  |:|  :.::.||.....|::  :..|.||:....|.:|          .|.|
Human   363 MNNAMKENGQA--GAA--SLVQHSRNMQFHGFNQLMRTDSNGNGISEYVIL----------DTNL 413

  Fly   434 GLRPVGTFIHRNSSLSSISKALPHQNLKLF--SPIDWVGGTRPAAAPRCGFG-GEKCVNYTGEIS 495
                      :...|.|.........|..|  :||.:.||..|.|..:|.|. |:.|   .|.|.
Human   414 ----------KEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKIC---HGGID 465

  Fly   496 AAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLN----- 555
            .|.|....|.| |::|:....:.|            |...:|:   :.|..:...|.||.
Human   466 PAFAMMVCLTL-LIALLSINGFAY------------FIRRRIN---KIQLIKGPNRILLTLEDVT 514

  Fly   556 ----HLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTP-------IGLYKGQLYAIKK--- 606
                |...:...:::.....||:|....:|...|...:: ||       |.:|:|....:||
Human   515 FINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSL-TPATYENSNIAIYEGDWVWLKKFSL 578

  Fly   607 --------VRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILE 663
                    ::.::.|:       .::::|.||:||...:|...|.....|::|:|:||||:|||.
Human   579 GDFGDLKSIKSRASDV-------FEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILT 636

  Fly   664 NEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFG----LFAFKQ 724
            |:|||||.||.:|::.|:|:|:.|||.... .||.|.:.||:||.|:|:|:||:|    |...:.
Human   637 NQDVKLDWMFKSSLLLDLIKGMKYLHHREF-VHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRL 700

  Fly   725 GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGL 789
            ..|:||.:         :||:.|||||| .|....:|:..||.|||.|::.|:.||..||....|
Human   701 SEEESSME---------ELLWTAPELLR-APRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDL 755

  Fly   790 TPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGM 854
            ...:.:.::.:|...   |||.:.|.....:|: :.:::||||..|.||.|..|..:.:...||.
Human   756 PAQEIINRLKKPPPV---YRPVVPPEHAPPECL-QLMKQCWAEAAEQRPTFDEIFNQFKTFNKGK 816

  Fly   855 RPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYE 919
            :.||.|:|:.|:|:|::|||.|:.:||::|:.||:||:.||.:|||..||:.||||..|:||.::
Human   817 KTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFD 881

  Fly   920 QVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNG 984
            .|::|||||||||.:||...|::|||.||||||.||:|||.:||||||||||||||.||||.|||
Human   882 LVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNG 946

  Fly   985 DLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTAS 1049
            ..||||||.|||.:||:|..||:||.|...:.:|||:|||||.||||||.|||||||||||||||
Human   947 SRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTAS 1011

  Fly  1050 RMESSGVPLKIHCSWQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYWLLGE 1100
            ||||:|:|.:||.|.....:|..|. ||....||...:||||.:.|:||:|:
Human  1012 RMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	81/396 (20%)
		PK_GC-A_B	570..853	CDD:270944	99/304 (33%)
		HNOBA	<860..907	CDD:462234	23/46 (50%)
		CYCc	886..1078	CDD:214485	125/192 (65%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	85/420 (20%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	95/292 (33%)
		HNOBA	<824..869	CDD:462234	22/44 (50%)
		CYCc	848..1040	CDD:214485	124/191 (65%)