DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10738 and GUCY2F

DIOPT Version :9

Sequence 1:NP_729905.2 Gene:CG10738 / 39516 FlyBaseID:FBgn0036368 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_001513.2 Gene:GUCY2F / 2986 HGNCID:4691 Length:1108 Species:Homo sapiens


Alignment Length:1092 Identity:361/1092 - (33%)
Similarity:553/1092 - (50%) Gaps:162/1092 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 AISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWT--QQVAAYIGPQET--CVHEG 128
            |..||:|.:|.....|..:|.::|:   ..|:..:.|..::..:  |..:.:|||...  |....
Human    75 AARLAIERINRDPSFDLSYSFEYVI---LNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAAS 136

  Fly   129 RMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASG 193
            .:..:::..:.|:.|.:.:..||..:|||:||.|...::   :|.::..|.|.....:..|:  .
Human   137 LLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDE--D 196

  Fly   194 QYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGL 258
            .:...|..:.|.|...|:.:..:.|      .|.........:::.:...||.:|:  ...|..|
Human   197 IWVHTANRVASALRSHGLPVGVVLT------TGQDSQSMRKALQRIHQADRIRIII--MCMHSAL 253

  Fly   259 MVSLQRRGIL--------SKGDYFVVGIDIEQYD-PAK--PEKYLRGLLLEDVEPLAVQAFQSYL 312
            :....:..:|        :.|.|..|..|...|. |.|  |.:.||.      .|...:|:.:.|
Human   254 IGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN------NPKLREAYDAVL 312

  Fly   313 GI-VPTASVSF------ATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKA 370
            .| |.:...:|      |....|:.:.:|   |:..:||  ||.:          |::::..|:|
Human   313 TITVESQEKTFYQAFTEAAARGEIPEKLE---FDQVSPL--FGTI----------YNSIYFIAQA 362

  Fly   371 LMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYH--VYIDENGDAAGNYTVLARGSVRNGRNQTVL 433
            :...:...|:.  |:|  :.::.||.....|::  :..|.||:....|.:|          .|.|
Human   363 MNNAMKENGQA--GAA--SLVQHSRNMQFHGFNQLMRTDSNGNGISEYVIL----------DTNL 413

  Fly   434 GLRPVGTFIHRNSSLSSISKALPHQNLKLF--SPIDWVGGTRPAAAPRCGFG-GEKCVNYTGEIS 495
                      :...|.|.........|..|  :||.:.||..|.|..:|.|. |:.|   .|.|.
Human   414 ----------KEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKIC---HGGID 465

  Fly   496 AAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLN----- 555
            .|.|....|.| |::|:....:.|            |...:|:   :.|..:...|.||.     
Human   466 PAFAMMVCLTL-LIALLSINGFAY------------FIRRRIN---KIQLIKGPNRILLTLEDVT 514

  Fly   556 ----HLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTP-------IGLYKGQLYAIKK--- 606
                |...:...:::.....||:|....:|...|...:: ||       |.:|:|....:||   
Human   515 FINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSL-TPATYENSNIAIYEGDWVWLKKFSL 578

  Fly   607 --------VRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILE 663
                    ::.::.|:       .::::|.||:||...:|...|.....|::|:|:||||:|||.
Human   579 GDFGDLKSIKSRASDV-------FEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILT 636

  Fly   664 NEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFG----LFAFKQ 724
            |:|||||.||.:|::.|:|:|:.|||.... .||.|.:.||:||.|:|:|:||:|    |...:.
Human   637 NQDVKLDWMFKSSLLLDLIKGMKYLHHREF-VHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRL 700

  Fly   725 GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGL 789
            ..|:||.:         :||:.|||||| .|....:|:..||.|||.|::.|:.||..||....|
Human   701 SEEESSME---------ELLWTAPELLR-APRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDL 755

  Fly   790 TPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGM 854
            ...:.:.::.:|...   |||.:.|.....:|: :.:::||||..|.||.|..|..:.:...||.
Human   756 PAQEIINRLKKPPPV---YRPVVPPEHAPPECL-QLMKQCWAEAAEQRPTFDEIFNQFKTFNKGK 816

  Fly   855 RPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYE 919
            :.||.|:|:.|:|:|::|||.|:.:||::|:.||:||:.||.:|||..||:.||||..|:||.::
Human   817 KTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFD 881

  Fly   920 QVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNG 984
            .|::|||||||||.:||...|::|||.||||||.||:|||.:||||||||||||||.||||.|||
Human   882 LVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNG 946

  Fly   985 DLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTAS 1049
            ..||||||.|||.:||:|..||:||.|...:.:|||:|||||.||||||.|||||||||||||||
Human   947 SRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTAS 1011

  Fly  1050 RMESSGVPLKIHCSWQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYWLLGE 1100
            ||||:|:|.:||.|.....:|..|. ||....||...:||||.:.|:||:|:
Human  1012 RMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10738NP_729905.2 PBP1_Speract_GC_like 41..441 CDD:107365 81/396 (20%)
ANF_receptor 67..416 CDD:279440 77/371 (21%)
PK_GC-A_B 570..853 CDD:270944 99/304 (33%)
TyrKc 597..847 CDD:197581 91/264 (34%)
HNOBA <862..907 CDD:285003 22/44 (50%)
CYCc 886..1078 CDD:214485 125/192 (65%)
Guanylate_cyc 913..1099 CDD:278633 119/186 (64%)
GUCY2FNP_001513.2 PBP1_sensory_GC_DEF_like 54..435 CDD:107366 85/420 (20%)
ANF_receptor 75..412 CDD:279440 79/387 (20%)
PKc_like 545..815 CDD:304357 95/292 (33%)
HNOBA <824..869 CDD:285003 22/44 (50%)
CYCc 848..1040 CDD:214485 124/191 (65%)
Guanylate_cyc 875..1062 CDD:278633 119/186 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D123766at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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