Protein Alignment CG10738 and GUCY2C

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_004954.2
• Gene: GUCY2C / 2984
• HGNCID: 4688
• Length: 1073
• Species: Homo sapiens
• Alignment Length: 1179
• Identity: 357/1179 - (30%)
• Similarity: 537/1179 - (45%)
• Gaps: 253/1179 - (21%)

  Fly    54 GNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETY----------GE------EVVS 102
            ||..:..|...:..|::..:|.|. |||::.|  |...|..|:          |:      |.:.
Human    43 GNSAFAEPLKNLEDAVNEGLEIVR-GRLQNAG--LNVTVNATFMYSDGLIHNSGDCRSSTCEGLD 104

  Fly   103 IRQTAALWTQQVAAYIGPQETCVH---EGRMAAAFNLPMIS-----YYCTHRDPSNKADFPTFAR 159
            :.:..:...:.....|||  :|.:   :..:....:.||||     ..|.:::        |..|
Human   105 LLRKISNAQRMGCVLIGP--SCTYSTFQMYLDTELSYPMISAGSFGLSCDYKE--------TLTR 159

  Fly   160 TRPPDTQISKSVVALLLAFNW--TQVSF-LYLDDASGQYQPVAET-----ILSTLTDAGVSIRDI 216
            ...|    ::.::..|:.| |  ..:.| .|....|..|:...||     .|:.| :|.||
Human   160 LMSP----ARKLMYFLVNF-WKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNAL-EASVS---- 214

  Fly   217 RTWNTIYHH--GF-----MDNPFEALVEQTYANTRIYLILG---HYYEHVGLMVSLQRRGILSKG 271
                 .:.|  ||     .|..|:.::......:.:.::.|   ..|:..|      .|.:..
Human   215 -----YFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKG------DRAVAE-- 266

  Fly   272 DYFVVGIDI--EQY--DPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKY 332
            |..::.:|:  :||  |......|::.:|:              |.:.|..|:..::|:..::..
Human   267 DIVIILVDLFNDQYFEDNVTAPDYMKNVLV--------------LTLSPGNSLLNSSFSRNLSPT 317

  Fly   333 MERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYR 397
            .......:.|.:..||.:.:|..|                          ||..|........:|
Human   318 KRDFALAYLNGILLFGHMLKIFLE--------------------------NGENITTPKFAHAFR 356

  Fly   398 SAM--GYH--VYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTF-IHRNSSLS-SISKALP 456
            :..  ||.  |.:|:.|| ..:..||...||...:.:.:|      |: .|.|.:.. .:|....
Human   357 NLTFEGYDGPVTLDDWGD-VDSTMVLLYTSVDTKKYKVLL------TYDTHVNKTYPVDMSPTFT 414

  Fly   457 HQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQ 521
            .:|.||  |.| :.|..|...               .|:.....||::||.||:|::.|.:|.:.
Human   415 WKNSKL--PND-ITGRGPQIL---------------MIAVFTLTGAVVLLLLVALLMLRKYRKDY 461

  Fly   522 ELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPL--IRTSQVSLSSNPDAD 584
            ||                      .||:..|        :||::..||  ..|:.|||..  |.|
Human   462 EL----------------------RQKKWSH--------IPPENIFPLETNETNHVSLKI--DDD 494

  Fly   585 FRYTTIFTPIGL----YKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPN 645
            .|..||..   |    |..:...:|.::....:.|.:.|.||..|....:.|:..|.|.......
Human   495 KRRDTIQR---LRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTM 556

  Fly   646 ICIISEYCTRGSLKDILENEDVK------LDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNC 704
            |..:.|||.||||:::| |:.:.      :|..|..|::.||.:|:.|||.|....||.|.::||
Human   557 IFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNC 620

  Fly   705 LVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYS 769
            :||||.|||:||||..:.....:|               |:.|||.|||...|     |:||.||
Human   621 VVDSRMVVKITDFGCNSILPPKKD---------------LWTAPEHLRQANIS-----QKGDVYS 665

  Fly   770 FGILLYEMHVRRGPFGETGLTPMQCL---QKVLQPQDY--LNPYRPSLQPLETAFDCVSE---CL 826
            :||:..|:.:|:    ||..| :.|.   :|:.:.::.  :.|:||.|. ||||.:...|   .:
Human   666 YGIIAQEIILRK----ETFYT-LSCRDRNEKIFRVENSNGMKPFRPDLF-LETAEEKELEVYLLV 724

  Fly   827 RECWAERPEDRPDFKTIRTKLRPL----RKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEE 887
            :.||.|.||.|||||.|.|.|..:    ......:..|.::..::.|:.|||.||::||...:.|
Human   725 KNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAE 789

  Fly   888 KKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYT 952
            :.:.|.|...:|||.|...||:...|:||.||:|:||||||||||.:....||::|||.|||:|.
Human   790 RDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYK 854

  Fly   953 CFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLL 1017
            .||.|:.|:||||||||||||||.||||.|||:.||.:||.|:|.:||.:..|::.|.|...:.:
Human   855 SFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWI 919

  Fly  1018 RIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLG-GYHFAER 1081
            |||:||||..|||||:||||||||||||||||||||:|:||:||.|.....:|.|.. .:.:..|
Human   920 RIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVR 984

  Fly  1082 GVISMKGKGDQRTYWLLG-EDEEAR--TRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRS 1143
            |...:||:|::.||||.| :|::..  |..|.|..||     |.......|..:.::....||||
Human   985 GETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQR-----LQAEFSDMIANSLQKRQAAGIRS 1044

  Fly  1144 SLKQKNLPR 1152
               ||  ||
Human  1045 ---QK--PR 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	81/436 (19%)
		PK_GC-A_B	570..853	CDD:270944	101/304 (33%)
		HNOBA	<860..907	CDD:462234	16/46 (35%)
		CYCc	886..1078	CDD:214485	110/192 (57%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:380592	85/454 (19%)
		PK_GC-C	480..750	CDD:270946	101/301 (34%)
		CYCc	788..979	CDD:214485	110/190 (58%)