Protein Alignment CG10738 and GUCY1B1

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 175/717 - (24%)
• Similarity: 264/717 - (36%)
• Gaps: 205/717 - (28%)

  Fly   509 VSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTS 573
            :.|::.||:..|      :|:...:|.|:     :::.|...|.:.:       ...|:.|:..:
Human     9 LELLVIRNYGPE------VWEDIKKEAQL-----DEEGQFLVRIIYD-------DSKTYDLVAAA 55

  Fly   574 QVSLSSNPD--------------ADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKL 624
            ...|:.|..              .:..|.||...:|                 ...||..:.|
Human    56 SKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLG-----------------SNVREFLQNL-- 101

  Fly   625 LRDARHDNICAFIGACTDPPNIC---------IISEYCTRGSLKDILENEDVKLDNMFIASMVAD 680
              ||.||::.........|...|         |:..|..|..|:||:         :.|...||.
Human   102 --DALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIV---------IGIIKTVAQ 155

  Fly   681 IIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDF--GLFAFKQ-GIEDSST----------- 731
            .|.|. .:....|:.....|.....:......|..||  .|..|:: |.::|..
Human   156 QIHGT-EIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPF 219

  Fly   732 ----DMQHMSAKCLKLLYRAPELLRQGPSSL--VMGTQRG--DAYSFGIL--LYEMHVRRGPFGE 786
                |...:..:|...:||....|:.|..||  |....|.  |....|||  :..:.|.|...|.
Human   220 HIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGL 284

  Fly   787 TGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPED-------RPDFKTIR 844
            ..:..::|       :|.|.         .|...|:.  |:......||.       .|....:.
Human   285 LDVEKLEC-------EDELT---------GTEISCLR--LKGQMIYLPEADSILFLCSPSVMNLD 331

  Fly   845 TKLR--------PLRKGMRPNIFDNMMAMME-KYANNLEALVDDRTDQLQ-------EEKKKTDA 893
            ...|        ||....|..:........| |....||.|    ||:||       :||||||.
Human   332 DLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL----TDRLQLTLRALEDEKKKTDT 392

  Fly   894 -------------------------------------------LLHEMLPRCVADQLKKGHKVDP 915
                                                       ||:.:||..||::|:....|..
Human   393 GCPARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPA 457

  Fly   916 EHYEQVSIYFSDIVGFTAMSAECT----PLQVVDFLNDLYTCFDSIIGHYD---VYKVETIGDAY 973
            :.|:.|:|.||.||||.|..::..    .:::|:.||||||.||::.....   ||||||:||.|
Human   458 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKY 522

  Fly   974 MVVSGLP---LRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKM 1035
            |.|||||   :.    ||..|..::|.::....:.::   ....:.:.||||:|.|..||:|.:|
Human   523 MTVSGLPEPCIH----HARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRM 580

  Fly  1036 PRYCLFGDTVNTASRMESSGVPLKIHCS---WQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYW 1096
            |||||||:|||..||.|::|...||:.|   ::|....:... .:|...||.:|||||.:....|
Human   581 PRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVW 645

  Fly  1097 LL 1098
            .|
Human   646 FL 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593
		PK_GC-A_B	570..853	CDD:270944	64/344 (19%)
		HNOBA	<860..907	CDD:462234	21/97 (22%)
		CYCc	886..1078	CDD:214485	80/248 (32%)
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233	37/205 (18%)
		HNOBA	207..449	CDD:462234	51/263 (19%)
		Guanylate_cyc	455..648	CDD:425528	77/200 (39%)