DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	845	Identity:	210/845 - (24%)
Similarity:	318/845 - (37%)	Gaps:	225/845 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 VSFATFANEVNKYMERPP------------FNF----PNPLGPFGGVKQISAEAAYLYDAVHLYA 368
            :|..:|::..:.|:|..|            :|.    |.||.|.......:|..|
Human     6 ISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA---------- 60

  Fly   369 KALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQT-- 431
                      ..|...:|..||..|:| |......|.:|..|::....|..:..:::....:|
Human    61 ----------PTPAASAAAAAATAGAR-RVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQ 114

  Fly   432 -----VLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYT 491
                 |:|.|......|..|:..|.:   .|.|.:   .|:.|.|.....|...|...|:.....
Human   115 YYEHQVIGYRDAEKNFHNISNRCSYA---DHSNKE---EIEDVSGILQCTANILGLKFEEIQKRF 173

  Fly   492 GEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRH---- 552
            ||                                     :|..:..|||||..::...|..
Human   174 GE-------------------------------------EFFNICFHENERVLRAVGGTLQDFFN 201

  Fly   553 ----LLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADF-------RYTTIFTPIGLYKGQLYAIKK 606
                ||.|:......|:|   :.:........|:...       .:...|..:|:.|.   |.||
Human   202 GFDALLEHIRTSFGKQAT---LESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKA---AGKK 260

  Fly   607 VRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILEN-----ED 666
            :.:..|::  |.....||..|..:...|:.:        ..:|.|......:|::.:.     .|
Human   261 IYRLDVEV--EQVANEKLCSDVSNPGNCSCL--------TFLIKECENTNIMKNLPQGTSQVPAD 315

  Fly   667 VKLD-NMFIAS----MVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTD-FGLFAFKQG 725
            :::. |.|..:    ::.|....|:.|.:      |......|  |:..|:|..| |.:.:.|
Human   316 LRISINTFCRAFPFHLMFDPSMSVLQLGE------GLRKQLRC--DTHKVLKFEDCFEIVSPK-- 370

  Fly   726 IEDSSTDMQHMSAKCLKLLYR--APELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETG 788
                      ::|...::|.|  .|.::|..|.:  .|::..|
Human   371 ----------VNATFERVLLRLSTPFVIRTKPEA--SGSENKD---------------------- 401

  Fly   789 LTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAE--RPEDRPDFKTIRTKLRPLR 851
                    ||::.:..:.....|...|.....||.: |.|....  ...|.|.....|.   .:.
Human   402 --------KVMEVKGQMIHVPESNSILFLGSPCVDK-LDELMGRGLHLSDIPIHDATRD---VIL 454

  Fly   852 KGMRPNIFDNMMAMMEKYANNLEALVDDRTDQ-LQEEKKKTDALLHEMLPRCVADQLKKGHKVDP 915
            .|.:....|.:...|:|....||     ||.| |:||||||..||:.:.|..||.||.:|.:|..
Human   455 VGEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQA 514

  Fly   916 EHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLP 980
            ..::.|::.|||||||||:.|:|||:||:..||:|||.||...|..|:||||||||||.|.:||.
Human   515 RKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLH 579

  Fly   981 LRNGDLHAAEIATMSLHLLSAVSE-------------------FKI-------RHRPTNRL---L 1016
             |....||..||.|:|.::....|                   |.:       :|:....|   .
Human   580 -RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEK 643

  Fly  1017 LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAER 1081
            :|||||||.|.|||||::||||||||:.|..||:.||...|.:|:.|....|||.|...:.|..|
Human   644 MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPR 708

Fly 1082 1081
Human 709 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	27/143 (19%)
		ANF_receptor	67..416	CDD:279440	22/111 (20%)
		PK_GC-A_B	570..853	CDD:270944	49/304 (16%)
		TyrKc	597..847	CDD:197581	46/264 (17%)
		HNOBA	<862..907	CDD:285003	19/45 (42%)
		CYCc	886..1078	CDD:214485	97/220 (44%)
		Guanylate_cyc	913..1099	CDD:278633	85/198 (43%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	25/155 (16%)
		HNOBA	316..503	CDD:285003	51/247 (21%)
		CYCc	485..705	CDD:214485	97/220 (44%)
		Guanylate_cyc	514..729	CDD:278633	84/196 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810