Protein Alignment CG10738 and Adcy8

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_058838.1
• Gene: Adcy8 / 29241
• RGDID: 2036
• Length: 1248
• Species: Rattus norvegicus
• Alignment Length: 370
• Identity: 106/370 - (28%)
• Similarity: 167/370 - (45%)
• Gaps: 60/370 - (16%)

  Fly   883 QLQEEKKKTDALLHEMLPR-CVADQLKKGHKVDPEH------------YEQVSIYFSDIVGFTAM 934
            :|:.|.::.:.|:..:||| .|.:.:.....|:.||            ||.|||.|:|:.|||.:
  Rat   359 RLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNL 423

  Fly   935 SAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLL 999
            |...:..::|..||:|:..||.:...:...:::.:||.|..|||||....| ||.....|.|.::
  Rat   424 STTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD-HAHCCVEMGLSMI 487

  Fly  1000 SAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSW 1064
            ..: .| :|.|..:.:.:|||||||.|..||:||:..::.::...|:.|:::||.|:|.:||.|
  Rat   488 KTI-RF-VRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHIS- 549

  Fly  1065 QCRQLLDRLGGYHFAERGVISMKGKGDQR----------TYWLLGEDEEAR-------TRRTYER 1112
              :..||.|.|.:..|      :|.|.:|          || |:.:.||:.       .:.:...
  Rat   550 --KATLDCLSGDYNVE------EGHGKERNEFLRKHNIETY-LIKQPEESLLSLPEDIVKESVSC 605

  Fly  1113 SQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLESPKKLRFAAGSLLEH 1177
            |.||.|.|  .|.:|:........|..|     ||..|.  :|||:|....|..|..|.     |
  Rat   606 SDRRNSGA--TFTEGSWSPELPFDNIVG-----KQNTLA--ALTRNSINLLPNHLAQAL-----H 656

  Fly  1178 HRYHSDEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTLSCQSIE 1222
            .:...:|....::....||   .|....|......||.....|:|
  Rat   657 VQSGPEEINKRIEHTIDLR---SGDKLRREHIKPFSLMFKDSSLE 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	7/24 (29%)
		CYCc	886..1078	CDD:214485	67/204 (33%)
		Guanylate_cyc	913..1099	CDD:278633	68/207 (33%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297	1..179
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..117
		AC_N	<158..397	CDD:292831	10/37 (27%)
		CYCc	363..561	CDD:214485	67/203 (33%)
		Guanylate_cyc	402..586	CDD:278633	65/196 (33%)
		DUF1053	614..708	CDD:283888	24/100 (24%)
		CYCc	941..1145	CDD:214485
		Guanylate_cyc	970..1169	CDD:278633
		Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	1106..1248
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1220..1248

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900