DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and Adcy10

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	334	Identity:	75/334 - (22%)
Similarity:	121/334 - (36%)	Gaps:	103/334 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 CW--AERP----EDRPDFKTIRTK-LRPLRKGMRPNIFDNMMAMMEKYAN-------NLEALVD- 878
            ||  .:|.    |..||.:.::.. |:|.........|...|..|:.|.:       .|..:::
Mouse   193 CWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFTKCMGFMDYYPSGDHKNFLRLACMLES 257

  Fly   879 DRTDQLQEEKKKTDALLHEMLPRCVADQLKKGH--KVDPEHYEQVSIYFS-----DIVGFTAMSA 936
            |...:|..:|...:.:|.:     :.|:..:|:  ::.|.....|::.|.     :::| :|:.|
Mouse   258 DPELELSLQKYVMEIILKQ-----IDDKQLRGYLSELRPVTIVFVNLMFKEQDKVEVIG-SAIQA 316

  Fly   937 ECTPLQVV-----DFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSL 996
            .|..:..|     ..:|.:: .||.             |.:::.|.|.|   |:....||.
Mouse   317 ACVHITSVLKVFRGQINKVF-MFDK-------------GCSFLCVFGFP---GEKAPDEIT---- 360

  Fly   997 HLL-SAVSEF-------KIRHRPTNRLLLRIGIHSGPVCAGVVGLKM-PRYCLFGDTVNTASRM- 1051
            |.| |||..|       |||       .:.||:.||.|..|:||..: ..|.:.|..||.|:||
Mouse   361 HALESAVDIFDFCSQVHKIR-------TVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARMM 418

  Fly  1052 --------------ESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQ-RTYWLLGED 1101
                          :.|.:|                 .|.|.|.....|||..|. ..|..||.:
Mouse   419 MYYPGIVSCDSVTYDGSNLP-----------------AYFFKELPKKVMKGVADPGPVYQCLGLN 466

  Fly  1102 EEARTRRTY 1110
            |:......|
Mouse   467 EKVMFGMAY 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	8/30 (27%)
		TyrKc	597..847	CDD:197581	6/24 (25%)
		HNOBA	<862..907	CDD:285003	9/52 (17%)
		CYCc	886..1078	CDD:214485	49/227 (22%)
		Guanylate_cyc	913..1099	CDD:278633	52/220 (24%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636	6/20 (30%)
		CHD	292..461	CDD:143636	50/214 (23%)
		COG3899	485..>959	CDD:226415
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900