Protein Alignment CG10738 and Gucy2c

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1249
• Identity: 354/1249 - (28%)
• Similarity: 533/1249 - (42%)
• Gaps: 332/1249 - (26%)

  Fly    16 GLLHPLLLLLFLLAFSNFRPT------------HGEVFTLGYLTASQRRPGNLDYNRPGLTISGA 68
            ||...|||         |:||            |...:.:..|...     |..|..|...:..|
  Rat     6 GLAVRLLL---------FQPTLMFWASQVRQKCHNGTYEISVLMMD-----NSAYKEPLQNLRDA 56

  Fly    69 ISLAVEEVNAGRLRDRGHSLQFVVAETY----------GE-------------EVVSIRQTAALW 110
            :.   |.::..|.|.|...|...|..|:          |:             |:...|:...:
  Rat    57 VE---EGLDIVRKRLREAELNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDRKMGCV- 117

  Fly   111 TQQVAAYIGPQETCVH---EGRMAAAFNLPMIS-----YYCTHRDPSNKADFPTFARTRPPDTQI 167
                  .:||  :|.:   :..:....|.||||     ..|.:::        |..|..||..::
  Rat   118 ------LMGP--SCTYSTFQMYLDTELNYPMISAGSFGLSCDYKE--------TLTRILPPARKL 166

  Fly   168 SKSVV-------ALLLAFNWTQVSFLYLDDASGQ----YQPVAETILSTLTDAGVSIRDI----- 216
            ...:|       |....|:|.. |::|.:.:..:    |....|..:|..::. :|.:|:
  Rat   167 MYFLVDFWKVNNAPFKTFSWNS-SYVYKNGSEPEDCFWYLNALEAGVSYFSEV-LSFKDVLRRSE 229

  Fly   217 ----------RTWNTIYHHGFMDNPFEALVEQTYANTRIYLIL----GHYYEHVGLMVSLQRRGI 267
                      |..|.|...|..:..:....:...|:..:.:::    .||:|
  Rat   230 QFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFE------------- 281

  Fly   268 LSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKY 332
                            |..:..:|:..:|:..:.|   :.|      :..||||
  Rat   282 ----------------DDTRAPEYMDNVLVLTLPP---EKF------IANASVS----------- 310

  Fly   333 MERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVA-----AIK 392
                 ..||:....|        ..||| :...|:...|...|:      ||.::..     |.:
  Rat   311 -----GRFPSERSDF--------SLAYL-EGTLLFGHMLQTFLE------NGESVTTPKFARAFR 355

  Fly   393 GSRYRSAMGYHVYIDENGDA------------AGNYTVLARGSVRNGRNQTVLGLRPVGT---FI 442
            ...::...| .|.:|::||.            ...|.||.  :....:|||:    ||.|   ||
  Rat   356 NLTFQGLEG-PVTLDDSGDIDNIMCLLYVSLDTRKYKVLM--AYDTHKNQTI----PVATSPNFI 413

  Fly   443 HRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLS 507
            .:|..|                         |...|  |.|.:..:     |:.....|.:::|.
  Rat   414 WKNHRL-------------------------PNDVP--GLGPQILM-----IAVFTLTGIVVVLL 446

  Fly   508 LVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLP-RRLPPQSTHPLIR 571
            |::|::.|.:|.:.||....|                          :|:| ..:.|..|:   .
  Rat   447 LIALLVLRKYRRDHELRQKKW--------------------------SHIPSENIFPLETN---E 482

  Fly   572 TSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSV-----DITREMKKELKLLRDARHD 631
            |:.|||..  |.|.|..|    |...:...|..|||..|.:     :.:.:.|.||..|..:.:.
  Rat   483 TNHVSLKI--DDDRRRDT----IQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYY 541

  Fly   632 NICAFIGACTDPPNICIISEYCTRGSLKDILENEDVK------LDNMFIASMVADIIRGVIYLHD 690
            |:..|.|.......|..:.|||.||||:::| |:.:.      :|..|..|::.||.:|:.|||.
  Rat   542 NLTKFYGTVKLDTRIFGVVEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHS 605

  Fly   691 SPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGP 755
            |.|..||.|.::||:||||.|||:||||..:.....:|               |:.|||.|||..
  Rat   606 SKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKD---------------LWTAPEHLRQAT 655

  Fly   756 SSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCL---QKVLQPQDY--LNPYRPSLQPL 815
            .|     |:||.|||.|:..|:.:|:    ||..| :.|.   :|:.:.::.  ..|:||.|. |
  Rat   656 IS-----QKGDVYSFSIIAQEIILRK----ETFYT-LSCRDQNEKIFRVENSYGTKPFRPDLF-L 709

  Fly   816 ETAFDCVSE---CLRECWAERPEDRPDFKTIRTKLRPL----RKGMRPNIFDNMMAMMEKYANNL 873
            |||.:...|   .::.||.|.||.|||||.|.:.|..:    ......:..|.::..::.|:.||
  Rat   710 ETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNL 774

  Fly   874 EALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAEC 938
            |.||::||...:.|:.:.|.|...:|||.|...||:...|:||.||:|:||||||||||.:....
  Rat   775 EHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYS 839

  Fly   939 TPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVS 1003
            ||::|||.|||:|..||.|:.|:||||||||||||:|.||||:|||:.||.:|:.|:|.:||.:.
  Rat   840 TPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMG 904

  Fly  1004 EFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQ 1068
            .|::.|.|...:.:|||:||||..|||||:||||||||||||||||||||:|:||:||.|.....
  Rat   905 TFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIA 969

  Fly  1069 LLDRLG-GYHFAERGVISMKGKGDQRTYWLLG-EDEEAR--TRRTYERSQRRGSRALNKFIQGTI 1129
            :|.|.. .:.:..||...:||:|.:.||||.| :|:|..  |..|.|..||     |.......|
  Rat   970 ILRRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTPPTVENQQR-----LQTEFSDMI 1029

  Fly  1130 KQAQEQANEYGIRS 1143
            ..|.::....|::|
  Rat  1030 VSALQKRQASGVKS 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	82/480 (17%)
		PK_GC-A_B	570..853	CDD:270944	102/305 (33%)
		HNOBA	<860..907	CDD:462234	16/46 (35%)
		CYCc	886..1078	CDD:214485	108/192 (56%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_type1	34..414	CDD:471960	83/482 (17%)
		Protein Kinases, catalytic domain	479..749	CDD:473864	103/305 (34%)
		CYCc	787..978	CDD:214485	108/190 (57%)