DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and Npr3

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_006232107.1	Gene:	Npr3 / 25339	RGDID:	3196	Length:	652	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	104/457 - (22%)
Similarity:	175/457 - (38%)	Gaps:	85/457 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 IGPQETCVHE----GRMAAAFNLPMISYYC-----THRDPSNKADFPTFARTRPPDTQISKSVVA 173
            :||  .|.:.    .|:|:.::|||:|...     .|:|    .::....|..|...::.:.::|
  Rat   243 LGP--VCEYAAAPVARLASHWDLPMLSAGALAAGFQHKD----TEYSHLTRVAPAYAKMGEMMLA 301

  Fly   174 LLLAFNWTQVSFLYLDD---------ASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMD 229
            |....:|::.:.||.||         ..|.::...|..|.|........:|:
  Rat   302 LFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDL------------- 353

  Fly   230 NPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRG 294
             ..:.:|.....:.|:.::.........:|:::.|.|:.| |||....|::..........:.||
  Rat   354 -DLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTS-GDYAFFNIELFNSSSYGDGSWKRG 416

  Fly   295 LLLEDVEPLAVQAFQSY--LGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEA 357
             ...|.|  |.||:.|.  :.::.||...|..|:.||...:|:...|..:.:..|         .
  Rat   417 -DKHDFE--AKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMF---------V 469

  Fly   358 AYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARG 422
            ...:||:.||..||.|||.:|...::|..|:.......:....| .|.||.|||..|:::|:|..
  Rat   470 EGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVVAMT 533

  Fly   423 SVRNGRNQTVLG--LRPVGTFIHRNS------SLS---SISKALPHQNLKLFSPIDWVGGTRPAA 476
            ....| .|.|:|  ....|.|..|::      ||.   ..::.:.|.|   .||....||...:|
  Rat   534 DTEAG-TQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTN---SSPCKSSGGLEESA 594

  Fly   477 APRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYR---NWRYEQELDSLLWKIDFREVQIH 538
            .             ||.:..|:.|..||:........||   ..|..||..::....:.||..|.
  Rat   595 V-------------TGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIR 646

  Fly   539 EN 540
            .:
  Rat   647 SH 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	79/344 (23%)
		ANF_receptor	67..416	CDD:279440	72/317 (23%)
		PK_GC-A_B	570..853	CDD:270944
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003
		CYCc	886..1078	CDD:214485
		Guanylate_cyc	913..1099	CDD:278633
Npr3	XP_006232107.1	PBP1_NPR_C_like	165..556	CDD:107381	80/347 (23%)
		ANF_receptor	182..535	CDD:279440	74/325 (23%)
		TM_EphA1	587..618	CDD:214014	9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810