DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	654	Identity:	183/654 - (27%)
Similarity:	283/654 - (43%)	Gaps:	178/654 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 IFTPIGLYKGQLYAIKKVRK--KSVDITREMKKEL------KLLRDARHDNICAFIGACTDPPNI 646
            :|....:| ..:..||.:::  |.:|::.|...:|      |..:.:.:|.:...:|
  Rat    34 VFMTYTVY-DDIITIKLIQEACKVLDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLG-------- 89

  Fly   647 CIISEYCTRGSLKDILENEDVKLDNMFIA--SMVADIIR------GVIYLHDSPIRFHGALC--- 700
                     |:|.:.:||.|.....:.::  .|.|...|      |.:.||....| || ||
  Rat    90 ---------GNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAMLLHYYSDR-HG-LCHIV 143

  Fly   701 ------TSNCLVDSRWVVKLTDF--------------------------GLFAFK-QGIEDSSTD 732
                  .:....|:...:.:.|.                          |..|.: ||.|||..|
  Rat   144 PGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQAD 208

  Fly   733 MQHMSAKCLKL------------------LYRAPELLRQGPSSLVMGTQRG-------------- 765
            .:.:....|::                  ..||..|..:||   :..|.:.
  Rat   209 QEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGP---LRDTFQPVYPERLWVEEEVFC 270

  Fly   766 DAYSFGILLYE-MHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSEC---- 825
            ||:.|.|:..| :.|:     :.|:...:.:..:|..:..|:.|...:.| :..|:..|.|
  Rat   271 DAFPFHIVFDEALRVK-----QAGVNIQKYVPGILTQKFALDEYFSIIHP-QVTFNISSICKFIN 329

  Fly   826 -------LRECWAERPEDRPDFK---------TIR-------TKLRPLR--KGMRPNIFD----- 860
                   .:|...:..:.:|..|         ::|       .|||.|:  :..:.::.|
  Rat   330 SQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPKLRSLQELEESKMHLSDIAPHD 394

  Fly   861 ----------------NMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKK 909
                            .:...:||....|..|    ::.|..|||||:.||:.|||..||:|||:
  Rat   395 TTRDLILLNQQRLAEMELSCQLEKKKEELRVL----SNHLAIEKKKTETLLYAMLPEHVANQLKE 455

  Fly   910 GHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYM 974
            |.||....:|..:|.|||:|.||.:.|.|.|:|:|:.||.:|:.||.:...:|||||||||||||
  Rat   456 GRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYM 520

  Fly   975 VVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNR-LLLRIGIHSGPVCAGVVGLKMPRY 1038
            ||.|:|: ..:.||..:|..:|.:  .:|..::.:..|.. :.:|:|||:|||.|||||.|||||
  Rat   521 VVGGVPV-PVESHAQRVANFALGM--RISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRY 582

  Fly  1039 CLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLL----- 1098
            |||||||||||||||.|:|.|:|.|....:.| :..|:....||.|.:||||...||:|:
  Rat   583 CLFGDTVNTASRMESHGLPSKVHLSPTAHRAL-KNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNA 646

  Fly  1099 GEDE 1102
            .|||
  Rat   647 TEDE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	66/376 (18%)
		TyrKc	597..847	CDD:197581	61/361 (17%)
		HNOBA	<862..907	CDD:285003	17/44 (39%)
		CYCc	886..1078	CDD:214485	98/192 (51%)
		Guanylate_cyc	913..1099	CDD:278633	91/191 (48%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	28/148 (19%)
		HNOBA	267..453	CDD:285003	40/195 (21%)
		CYCc	432..622	CDD:214485	98/193 (51%)
		Guanylate_cyc	459..642	CDD:278633	91/186 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810