Protein Alignment CG10738 and Gucy1b1

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_036901.2
• Gene: Gucy1b1 / 25202
• RGDID: 2769
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 178/692 - (25%)
• Similarity: 269/692 - (38%)
• Gaps: 170/692 - (24%)

  Fly   509 VSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTS 573
            :.|::.||:..|      :|:...:|.|:     :::.|...|.:.:       ...|:.|:..:
  Rat     9 LELLVIRNYGPE------VWEDIKKEAQL-----DEEGQFLVRIIYD-------DSKTYDLVAAA 55

  Fly   574 QVSLSSNPD--------------ADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKL 624
            ...|:.|..              .:..|.||...:|                 ...||..:.|
  Rat    56 SKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLG-----------------SNVREFLQNL-- 101

  Fly   625 LRDARHDNICAFIGACTDPPNIC---------IISEYCTRGSLKDILENEDVKLDNMFIASMVAD 680
              ||.||::.........|...|         |:..|..|..|:||:         :.|...||.
  Rat   102 --DALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIV---------IGIIKTVAQ 155

  Fly   681 IIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDF--GLFAFKQ-GIEDSST----------- 731
            .|.|. .:....|:.....|.....:......|..||  .|..|:: |.:||..
  Rat   156 QIHGT-EIDMKVIQQRSEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQDSRISPYTFCKAFPF 219

  Fly   732 ----DMQHMSAKCLKLLYRAPELLRQGPSSL--VMGTQRG--DAYSFGIL--LYEMHVRRGPFGE 786
                |...:..:|...:||....|:.|..||  |....|.  |....|||  :..:.|.|...|.
  Rat   220 HIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGL 284

  Fly   787 TGLTPMQCLQKV---------LQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKT 842
            ..:..::|..::         |:.|....|...|:     .|.|               .|....
  Rat   285 LDVEKLECEDELTGAEISCLRLKGQMIYLPEADSI-----LFLC---------------SPSVMN 329

  Fly   843 IRTKLR--------PLRKGMRPNIFDNMMAMME-KYANNLEALVDDRTDQLQ-------EEKKKT 891
            :....|        ||....|..:........| |....||.|    ||:||       :|||||
  Rat   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL----TDRLQLTLRALEDEKKKT 390

  Fly   892 DALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECT----PLQVVDFLNDLYT 952
            |.||:.:||..||::|:....|..:.|:.|:|.||.||||.|..::..    .:::|:.||||||
  Rat   391 DTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYT 455

  Fly   953 CFDSIIGHYD---VYKVETIGDAYMVVSGLP---LRNGDLHAAEIATMSLHLLSAVSEFKIRHRP 1011
            .||::.....   ||||||:||.||.|||||   :.    ||..|..::|.::....:.::   .
  Rat   456 RFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIH----HARSICHLALDMMEIAGQVQV---D 513

  Fly  1012 TNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCS---WQCRQLLDRL 1073
            ...:.:.||||:|.|..||:|.:||||||||:|||..||.|::|...||:.|   ::|....:..
  Rat   514 GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578

  Fly  1074 G-GYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQ 1114
            . .:|...||.:|||||.:....|.|..    :...|.|.:|
  Rat   579 DPQFHLEHRGPVSMKGKKEPMQVWFLSR----KNTGTEETNQ 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593
		PK_GC-A_B	570..853	CDD:270944	64/346 (18%)
		HNOBA	<860..907	CDD:462234	21/54 (39%)
		CYCc	886..1078	CDD:214485	80/205 (39%)
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:462233	37/205 (18%)
		HNOBA	207..406	CDD:462234	50/222 (23%)
		Guanylate_cyc	412..605	CDD:425528	76/199 (38%)