DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Npr1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1132	Identity:	420/1132 - (37%)
Similarity:	597/1132 - (52%)	Gaps:	145/1132 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLHPLLLLLFLLAFSNFRPTHGEVFTLGY---LTASQRRPGNLDYNRPGLTISGAISLAVEEVNA 78
            ||.|||||         |..|....|:..   ||       |..|......:..|:.||:..|.|
  Rat    16 LLPPLLLL---------RGGHASDLTVAVVLPLT-------NTSYPWSWARVGPAVELALARVKA 64

  Fly    79 GRLRDRGHSLQFVVAETYGEEVVSIRQTAAL------WTQQVAAYIGPQETCVHE----GRMAAA 133
            ......|.:::.|:..:.....|.....|.|      |....|.::||  .||:.    ||..|.
  Rat    65 RPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGP--GCVYSAAPVGRFTAH 127

  Fly   134 FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQP- 197
            :.:|:::..........|.::....||.|...::...|.||.....|...:.:...|..|..:|
  Rat   128 WRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPC 192

  Fly   198 --VAETILSTLTDAGVSIRDIRTWN-TIYHHGFMD---NPFEALVEQTYANTRIYLILGHYYEHV 256
              :.|         |:.:|.....| |:.|..|::   :.:..|:.......|:..|........
  Rat   193 FFIVE---------GLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFR 248

  Fly   257 GLMVSLQRRGILSKGDYFVVGIDI--------EQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLG 313
            .||:.....|:..: ||....:|:        :...|.||  :.||   :..:..|.||||
  Rat   249 NLMLLALNAGLTGE-DYVFFHLDVFGQSLKSAQGLVPQKP--WERG---DGQDRSARQAFQ---- 303

  Fly   314 IVPTASVSFATFANEVN-KYME---------RPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYA 368
                 :....|:....| :|:|         ...|||...    .|:|.|.  .|..:|.:.||.
  Rat   304 -----AAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVE----DGLKNII--PASFHDGLLLYV 357

  Fly   369 KALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVL 433
            :|:.|.|..||...:|..|...:....::...|| :.||.|||...::: |.......|..:.||
  Rat   358 QAVTETLAQGGTVTDGENITQRMWNRSFQGVTGY-LKIDRNGDRDTDFS-LWDMDPETGAFRVVL 420

  Fly   434 GLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGE--KCVN---YTGE 493
            ...  ||    :..|.::|:   |   ||:.|:    |..|...|:|||..|  .|..   .|.|
  Rat   421 NYN--GT----SQELMAVSE---H---KLYWPL----GYPPPDVPKCGFDNEDPACNQDHFSTLE 469

  Fly   494 ISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLP 558
            :.|.:...:|:...:||..:||..:.|:||.|.||::.:.::|....||..:|......|..
  Rat   470 VLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSG--- 531

  Fly   559 RRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELK 623
                        |.|........:..|:   :|.....|||.|.|:|:|.:|.:::||::..|||
  Rat   532 ------------RGSNYGSLLTTEGQFQ---VFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELK 581

  Fly   624 LLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYL 688
            .:||.:::::..|:|||||||||||::|||.||||:||||||.:.||.||..|:..||::|:::|
  Rat   582 HMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFL 646

  Fly   689 HDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQ 753
            |:..|..||.|.:|||:||.|:|:|:||:||.:|:    |...:..|  ....|.|:.||||||.
  Rat   647 HNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DPEPEQGH--TLFAKKLWTAPELLRM 705

  Fly   754 GPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETG--LTPMQCLQKVL---QPQDYLNPYRPSLQ 813
            . |....|:|.||.|||||:|.|:.:|.|.|...|  |:|.:.:::|.   ||     |:|||:.
  Rat   706 A-SPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQP-----PFRPSMD 764

  Fly   814 PLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVD 878
             |::..:.:.:.::.||||.|::||.|:.||..||...|....||.||:::.||:||||||.||:
  Rat   765 -LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVE 828

  Fly   879 DRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQV 943
            :||....|||:|.:|||:::||..||:|||:|..|..|.::.|:|||||||||||:|||.||:||
  Rat   829 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV 893

  Fly   944 VDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIR 1008
            |..|||||||||::|.::|||||||||||||||||||:|||.|||.|:|.|:|.||.||..|:||
  Rat   894 VTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIR 958

  Fly  1009 HRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRL 1073
            |||..:|.||||||:||||||||||||||||||||||||||||||:|..||||.|.:.:.:|:..
  Rat   959 HRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEF 1023

  Fly  1074 GGYHFAERGVISMKGKGDQRTYWLLGE 1100
            .|:....||.:.|||||..||||||||
  Rat  1024 DGFELELRGDVEMKGKGKVRTYWLLGE 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	95/437 (22%)
		ANF_receptor	67..416	CDD:279440	85/383 (22%)
		PK_GC-A_B	570..853	CDD:270944	119/287 (41%)
		TyrKc	597..847	CDD:197581	113/254 (44%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	131/191 (69%)
		Guanylate_cyc	913..1099	CDD:278633	128/185 (69%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	101/459 (22%)
		ANF_receptor	50..410	CDD:279440	86/393 (22%)
		PK_GC-A_B	530..803	CDD:270944	119/303 (39%)
		TyrKc	543..797	CDD:197581	115/269 (43%)
		HNOBA	<812..857	CDD:285003	23/44 (52%)
		CYCc	836..1025	CDD:214485	130/188 (69%)
		Guanylate_cyc	863..1049	CDD:278633	128/185 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720