Protein Alignment CG10738 and Npr1

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_036745.1
• Gene: Npr1 / 24603
• RGDID: 3195
• Length: 1057
• Species: Rattus norvegicus
• Alignment Length: 1132
• Identity: 420/1132 - (37%)
• Similarity: 597/1132 - (52%)
• Gaps: 145/1132 - (12%)

  Fly    17 LLHPLLLLLFLLAFSNFRPTHGEVFTLGY---LTASQRRPGNLDYNRPGLTISGAISLAVEEVNA 78
            ||.|||||         |..|....|:..   ||       |..|......:..|:.||:..|.|
  Rat    16 LLPPLLLL---------RGGHASDLTVAVVLPLT-------NTSYPWSWARVGPAVELALARVKA 64

  Fly    79 GRLRDRGHSLQFVVAETYGEEVVSIRQTAAL------WTQQVAAYIGPQETCVHE----GRMAAA 133
            ......|.:::.|:..:.....|.....|.|      |....|.::||  .||:.    ||..|.
  Rat    65 RPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGP--GCVYSAAPVGRFTAH 127

  Fly   134 FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQP- 197
            :.:|:::..........|.::....||.|...::...|.||.....|...:.:...|..|..:|
  Rat   128 WRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPC 192

  Fly   198 --VAETILSTLTDAGVSIRDIRTWN-TIYHHGFMD---NPFEALVEQTYANTRIYLILGHYYEHV 256
              :.|         |:.:|.....| |:.|..|::   :.:..|:.......|:..|........
  Rat   193 FFIVE---------GLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFR 248

  Fly   257 GLMVSLQRRGILSKGDYFVVGIDI--------EQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLG 313
            .||:.....|:..: ||....:|:        :...|.||  :.||   :..:..|.||||
  Rat   249 NLMLLALNAGLTGE-DYVFFHLDVFGQSLKSAQGLVPQKP--WERG---DGQDRSARQAFQ---- 303

  Fly   314 IVPTASVSFATFANEVN-KYME---------RPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYA 368
                 :....|:....| :|:|         ...|||...    .|:|.|.  .|..:|.:.||.
  Rat   304 -----AAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVE----DGLKNII--PASFHDGLLLYV 357

  Fly   369 KALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVL 433
            :|:.|.|..||...:|..|...:....::...|| :.||.|||...::: |.......|..:.||
  Rat   358 QAVTETLAQGGTVTDGENITQRMWNRSFQGVTGY-LKIDRNGDRDTDFS-LWDMDPETGAFRVVL 420

  Fly   434 GLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGE--KCVN---YTGE 493
            ...  ||    :..|.::|:   |   ||:.|:    |..|...|:|||..|  .|..   .|.|
  Rat   421 NYN--GT----SQELMAVSE---H---KLYWPL----GYPPPDVPKCGFDNEDPACNQDHFSTLE 469

  Fly   494 ISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLP 558
            :.|.:...:|:...:||..:||..:.|:||.|.||::.:.::|....||..:|......|..
  Rat   470 VLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSG--- 531

  Fly   559 RRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELK 623
                        |.|........:..|:   :|.....|||.|.|:|:|.:|.:::||::..|||
  Rat   532 ------------RGSNYGSLLTTEGQFQ---VFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELK 581

  Fly   624 LLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYL 688
            .:||.:::::..|:|||||||||||::|||.||||:||||||.:.||.||..|:..||::|:::|
  Rat   582 HMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFL 646

  Fly   689 HDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQ 753
            |:..|..||.|.:|||:||.|:|:|:||:||.:|:    |...:..|  ....|.|:.||||||.
  Rat   647 HNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DPEPEQGH--TLFAKKLWTAPELLRM 705

  Fly   754 GPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETG--LTPMQCLQKVL---QPQDYLNPYRPSLQ 813
            . |....|:|.||.|||||:|.|:.:|.|.|...|  |:|.:.:::|.   ||     |:|||:.
  Rat   706 A-SPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQP-----PFRPSMD 764

  Fly   814 PLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVD 878
             |::..:.:.:.::.||||.|::||.|:.||..||...|....||.||:::.||:||||||.||:
  Rat   765 -LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVE 828

  Fly   879 DRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQV 943
            :||....|||:|.:|||:::||..||:|||:|..|..|.::.|:|||||||||||:|||.||:||
  Rat   829 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV 893

  Fly   944 VDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIR 1008
            |..|||||||||::|.::|||||||||||||||||||:|||.|||.|:|.|:|.||.||..|:||
  Rat   894 VTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIR 958

  Fly  1009 HRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRL 1073
            |||..:|.||||||:||||||||||||||||||||||||||||||:|..||||.|.:.:.:|:..
  Rat   959 HRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEF 1023

  Fly  1074 GGYHFAERGVISMKGKGDQRTYWLLGE 1100
            .|:....||.:.|||||..||||||||
  Rat  1024 DGFELELRGDVEMKGKGKVRTYWLLGE 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	95/437 (22%)
		PK_GC-A_B	570..853	CDD:270944	119/287 (41%)
		HNOBA	<860..907	CDD:462234	25/46 (54%)
		CYCc	886..1078	CDD:214485	131/191 (69%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:380608	101/459 (22%)
		PK_GC-A_B	530..803	CDD:270944	119/303 (39%)
		HNOBA	<809..857	CDD:462234	25/47 (53%)
		CYCc	836..1025	CDD:214485	130/188 (69%)