Protein Alignment CG10738 and Gucy2g

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_620611.2
• Gene: Gucy2g / 245708
• RGDID: 621853
• Length: 1103
• Species: Rattus norvegicus
• Alignment Length: 1175
• Identity: 379/1175 - (32%)
• Similarity: 573/1175 - (48%)
• Gaps: 187/1175 - (15%)

  Fly    14 HSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNA 78
            ||.|:..|.:::.:......:           ||.....|.|:.:......:...:.:||:::|:
  Rat    28 HSSLVLTLFVVMLMTCLEAAK-----------LTVGFHAPWNISHPFSVQRLGAGLQIAVDKLNS 81

  Fly    79 GRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQV-----AAYIGP--QETCVHEGRMAAAFNL 136
            ..:.....|.:|    ||.....:.:::.|.:..||     :..|||  .|.....|.:|:.:::
  Rat    82 EPVGPGNLSWEF----TYTNATCNAKESLAAFIDQVQREHISVLIGPACPEAAEVIGLLASEWDI 142

  Fly   137 PMIS-----------YYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDD 190
            |:..           ::|           .|.....||..:|...:...|....|..:.......
  Rat   143 PLFDFVGQMTALEDHFWC-----------DTCVTLVPPKQEIGTVLRESLQYLGWEYIGVFGGSS 196

  Fly   191 ASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEH 255
            |...:..|.|  |....:..:.:....|....|..|..|...|.|...: :..|:.:::....:.
  Rat   197 AGSSWGEVNE--LWKAVEDELQLHFTITARVRYSSGHSDLLQEGLRSMS-SVARVIILICSSEDA 258

  Fly   256 VGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT--- 317
            ..::.:.:..|:.|:...|::   ::|.:    :.:.:.:|.||......:.::|...|.|:
  Rat   259 KHILQAAEDLGLNSREFVFLL---LQQLE----DSFWKEVLAEDKVTRFPKVYESVFLIAPSTYG 316

  Fly   318 ASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPR 382
            .|.....|..:|.:.:.||||.     .......|:|..:|||:||:.|||:.:.|::.:....|
  Rat   317 GSAGDDDFRKQVYQRLRRPPFQ-----SSISSEDQVSPYSAYLHDALLLYAQTVEEMMKAEKDFR 376

  Fly   383 NGSAIVAAIKGSRYR-SAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNS 446
            :|..:::.::..:.. ..:...|.:|..|....:|:|.|.....||..     ..|   |:|.:|
  Rat   377 DGRQLISTLRADQVTLQGITGPVLLDAQGKRHMDYSVYALQKSGNGSR-----FLP---FLHYDS 433

  Fly   447 S-------LSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKC-------VNYTGEISAA 497
            .       ...::.:.||             |:.|...|.|||..:.|       ...|..::|.
  Rat   434 FQKVIRPWRDDLNASGPH-------------GSHPEYKPDCGFHEDLCRTKPPTGAGMTASVTAV 485

  Fly   498 IAGGALLLL----SLVSLVLYR-NWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHL 557
            |....||::    ::..|:|:| ..:.:.......|:|.:..:.:                   |
  Rat   486 IPTVTLLVVASAAAITGLMLWRLRGKVQNHPGDTWWQIHYDSITL-------------------L 531

  Fly   558 PRRLPPQSTHPLIR-----TSQVSLSSNPDADFRYT-----TIFTPIGLYKGQLYAI-------- 604
            |:..|.....|:.|     .|.|.:|:: ...|..|     ..:.|:|||:|...|:
  Rat   532 PQHKPSHRGTPMSRCNVSNASTVKISAD-CGSFAKTHQDEELFYAPVGLYQGNHVALCYIGEEAE 595

  Fly   605 KKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKL 669
            .:::|.:|      .:|:.|:.:.:|:||..|.|.||:||||||:::.|.:|||||:|.|.|.::
  Rat   596 ARIKKPTV------LREVWLMCELKHENIVPFFGVCTEPPNICIVTQCCKKGSLKDVLRNSDHEM 654

  Fly   670 DNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQG-----IEDS 729
            |.:|..|.|.||:.|:::||.||:|.||.|..|||||||...:||..|||:.||.|     ....
  Rat   655 DWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEFKHGSTCRIYNQE 719

  Fly   730 STDMQHMSAKCLKLLYRAPEL--LRQGPSSLVMGTQRGDAYSFGILLYEM-HVR-RGPFGETGLT 790
            :||..       :|.:.||||  ||:.|.|   ||.:||.|||.|||.:: |.: .|||.:....
  Rat   720 ATDHS-------ELYWTAPELLRLRELPWS---GTPQGDVYSFAILLRDLIHQQAHGPFEDLEAA 774

  Fly   791 P---MQCLQKVLQPQDYLNPYRPSLQPLETAFD-CVSECLRECWAERPEDRPDFKTIRTKLRPLR 851
            |   :.|::....|.    |.||||  ||...| .:...:|.||||.||.||.|.:|:..||...
  Rat   775 PEEIISCIKDSRAPV----PLRPSL--LEDKGDERIVALVRACWAESPEQRPAFPSIKKTLREAS 833

  Fly   852 KGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPE 916
            ...|.:|.|:||..:|.||::||.:|::||.||..||:|.:.||..|||..|.:||..|..|:||
  Rat   834 PRGRVSILDSMMGKLEMYASHLEEVVEERTCQLVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPE 898

  Fly   917 HYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPL 981
            |:|.|:|:||||||||.:.:..:|||||..|||||:.||..|..:||||||||||||||.||||:
  Rat   899 HFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIGDAYMVASGLPI 963

  Fly   982 RNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVN 1046
            |||..||.|||||||||||..:.|:|.|.|..||.||||:|:|||.|||||:.||||||||||||
  Rat   964 RNGAQHADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVN 1028

  Fly  1047 TASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGED---------- 1101
            .|||||||.:||:||.|....:.|...||||..:||.||:||||:|.|:||.|:|
  Rat  1029 MASRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWLTGKDGFAVPLPEFT 1093

  Fly  1102 -EEAR 1105
             |||:
  Rat  1094 EEEAK 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	78/421 (19%)
		PK_GC-A_B	570..853	CDD:270944	117/313 (37%)
		HNOBA	<860..907	CDD:462234	22/46 (48%)
		CYCc	886..1078	CDD:214485	121/191 (63%)
Gucy2g	NP_620611.2	PBP1_GC_G-like	50..439	CDD:380595	80/426 (19%)
		PK_GC	558..832	CDD:270894	113/296 (38%)
		CYCc	868..1058	CDD:214485	119/189 (63%)