DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10738 and PHLPP1

DIOPT Version :9

Sequence 1:NP_729905.2 Gene:CG10738 / 39516 FlyBaseID:FBgn0036368 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_919431.2 Gene:PHLPP1 / 23239 HGNCID:20610 Length:1717 Species:Homo sapiens


Alignment Length:810 Identity:142/810 - (17%)
Similarity:243/810 - (30%) Gaps:311/810 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   535 VQIH-ENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYK 598
            ||:| |..|..:::::...:.|....:|   ....|.|..:..:.|......|:         |.
Human   473 VQLHGETTRRLEAEEKPLQIQNDYLFQL---GFGELWRVQEEGMDSEIGCLIRF---------YA 525

  Fly   599 GQLYAI---KKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKD 660
            |:.::.   ::::...:...|:.|.:|.:.|..|...|  ..|.|      .|:|      |:||
Human   526 GKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVI--LCGTC------LIVS------SVKD 576

  Fly   661 ILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGA--------LCTSNCLVDSRWVVKLTDF 717
            .|..:      |.:..::...:..| ..|...:.|..:        :|........||:.:::..
Human   577 SLTGK------MHVLPLIGGKVEEV-KKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKV 634

  Fly   718 GLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPEL---------LRQGPS----------------- 756
            ..... ..::.|...::|:.|.    |:.:.:|         |||.||                 
Human   635 ASQRI-SSVDLSCCSLEHLPAN----LFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLK 694

  Fly   757 SLVMGTQRGDAYSFGI----LLYEMHV-----RRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSL 812
            ||.:.......:...:    .|.|::|     |..|   ..:..|..||..|...::|......|
Human   695 SLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVP---AAVGVMHNLQTFLLDGNFLQSLPAEL 756

  Fly   813 QPLE----------------------TAFD--CVS-ECLRECWAERPEDRPDFKTIRTKLRPLRK 852
            :.::                      ||.|  |:| .|:.....:.....|..|.:..:|..:||
Human   757 ENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRK 821

  Fly   853 GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKK---------KTDALLHEMLPRCVADQLK 908
                                   |:.|..|.||...:         ..||::.            
Human   822 -----------------------LIADEVDFLQHVTQLDLRDNKLGDLDAMIF------------ 851

  Fly   909 KGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAY 973
              :.::..|.|:..:...||.|:              ||..||...:.:: ..|||.|... .:|
Human   852 --NNIEVLHCERNQLVTLDICGY--------------FLKALYASSNELV-QLDVYPVPNY-LSY 898

  Fly   974 MVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRY 1038
            |.||...|.|                  |.|:....|...  :|.|| |: .:|.          
Human   899 MDVSRNRLEN------------------VPEWVCESRKLE--VLDIG-HN-QICE---------- 931

  Fly  1039 CLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1103
                             :|.::.|:...|:|                           |.|.::.
Human   932 -----------------LPARLFCNSSLRKL---------------------------LAGHNQL 952

  Fly  1104 ARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSLTRSSSLE----SP 1164
            ||.....||:              :::....|.|:.        ..||.|.|.::.||.    |.
Human   953 ARLPERLERT--------------SVEVLDVQHNQL--------LELPPNLLMKADSLRFLNASA 995

  Fly  1165 KKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGSTQSRYEE---TTLSLTLSCQSIEIVGG 1226
            .||.....:.|      |:|                  |.|..:|   |..|||..|..: :.|.
Human   996 NKLESLPPATL------SEE------------------TNSILQELYLTNNSLTDKCVPL-LTGH 1035

  Fly  1227 QHNK------RRPSSYPTANTPLLMNHVEV 1250
            .|.|      .|..|:|.:....|....|:
Human  1036 PHLKILHMAYNRLQSFPASKMAKLEELEEI 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10738NP_729905.2 PBP1_Speract_GC_like 41..441 CDD:107365
ANF_receptor 67..416 CDD:279440
PK_GC-A_B 570..853 CDD:270944 59/353 (17%)
TyrKc 597..847 CDD:197581 54/320 (17%)
HNOBA <862..907 CDD:285003 7/53 (13%)
CYCc 886..1078 CDD:214485 33/200 (17%)
Guanylate_cyc 913..1099 CDD:278633 32/185 (17%)
PHLPP1NP_919431.2 leucine-rich repeat 1107..1129 CDD:275380
PP2Cc 1168..1420 CDD:214625
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1458..1510
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1673..1717
PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269|PubMed:21804599 1715..1717
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..118
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..156
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 252..470
PH_PHLPP-like 535..631 CDD:270131 21/116 (18%)
PH 555..636 CDD:278594 18/101 (18%)
LRR_RI 625..929 CDD:238064 69/386 (18%)
LRR_8 638..703 CDD:290566 12/69 (17%)
LRR 1 638..659 4/25 (16%)
leucine-rich repeat 641..661 CDD:275380 4/23 (17%)
LRR 2 661..682 6/20 (30%)
leucine-rich repeat 662..692 CDD:275380 6/29 (21%)
LRR 3 692..712 2/19 (11%)
leucine-rich repeat 693..738 CDD:275380 8/47 (17%)
LRR_8 714..770 CDD:290566 11/58 (19%)
LRR 4 715..736 5/23 (22%)
LRR 5 738..760 5/21 (24%)
leucine-rich repeat 739..761 CDD:275380 5/21 (24%)
LRR 6 761..783 0/21 (0%)
leucine-rich repeat 762..784 CDD:275380 0/21 (0%)
LRR 7 784..804 5/19 (26%)
leucine-rich repeat 785..808 CDD:275380 4/22 (18%)
LRR 8 808..831 7/45 (16%)
leucine-rich repeat 810..832 CDD:275380 8/44 (18%)
LRR_RI 814..1074 CDD:238064 77/428 (18%)
LRR 9 832..853 2/34 (6%)
leucine-rich repeat 833..853 CDD:275380 2/33 (6%)
leucine-rich repeat 854..895 CDD:275380 13/55 (24%)
LRR 10 873..894 8/21 (38%)
LRR 11 895..916 8/39 (21%)
leucine-rich repeat 896..918 CDD:275380 8/39 (21%)
LRR 12 918..939 6/51 (12%)
leucine-rich repeat 919..941 CDD:275380 7/52 (13%)
LRR 13 941..962 7/47 (15%)
leucine-rich repeat 942..963 CDD:275380 8/61 (13%)
LRR_8 962..1024 CDD:290566 18/107 (17%)
LRR 14 963..984 6/28 (21%)
leucine-rich repeat 964..987 CDD:275380 6/30 (20%)
LRR 15 987..1008 6/26 (23%)
leucine-rich repeat 988..1011 CDD:275380 7/46 (15%)
LRR 16 1013..1033 6/20 (30%)
LRR_8 1014..1072 CDD:290566 14/53 (26%)
leucine-rich repeat 1014..1037 CDD:275380 7/23 (30%)
LRR 17 1037..1058 5/20 (25%)
leucine-rich repeat 1038..1061 CDD:275380 5/22 (23%)
LRR 18 1061..1082 1/5 (20%)
Interaction with SLC9A3R1. /evidence=ECO:0000269|PubMed:21804599 1076..1205
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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