DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Npr2

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_776149.1	Gene:	Npr2 / 230103	MGIID:	97372	Length:	1047	Species:	Mus musculus

Alignment Length:	1121	Identity:	424/1121 - (37%)
Similarity:	593/1121 - (52%)	Gaps:	121/1121 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDR 84
            |.|||:........||......||..:....    ||.|......:..|::||||.:......|
Mouse     4 PSLLLVVAALAGGVRPPGARNLTLAVVLPEH----NLSYAWAWPRVGPAVALAVEALGRALPVD- 63

  Fly    85 GHSLQFVVAETYG---EEVVSIRQTAALWTQQVAAYIGPQETCVHE----GRMAAAFNLPMISYY 142
               |:||.:|..|   |.:..:|.............:||  .||:.    .|.|:.:.||:::..
Mouse    64 ---LRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGP--GCVYPAASVARFASHWRLPLLTAG 123

  Fly   143 CTHRDPSNKAD-FPTFARTRPPDTQISKSVVALLLAFNWT-QVSFLYLD---DASGQYQPVAETI 202
            ......:.|.: :.|..||.|...::.:.||.|...|||| :.:.||||   |....|..: |.:
Mouse   124 AVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTI-EGV 187

  Fly   203 LSTLTDAGVSIRDIRTWNTIYHHGFMDNPF--EALVEQTYANTRIYLILGHYYEHVGLMVSLQRR 265
            ...|..:.:|::         |..:...|.  |.......||.||..|.|.......:::..||.
Mouse   188 FEALQGSNLSVQ---------HQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRE 243

  Fly   266 GILSKGDYFVVGIDI--------------EQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIV- 315
            . |:.|||....:|:              ..:...:.::..:.|.         :|||:.|.|.
Mouse   244 N-LTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQAQALR---------EAFQTVLVITY 298

  Fly   316 -PTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGG 379
             ...:..:..|.   |:.:.|...:|...|.|    ..::..|...||.:.|||:.|.|.:..||
Mouse   299 REPPNPEYQEFQ---NRLLIRAREDFGVELAP----SLMNLIAGCFYDGILLYAQVLNETIQEGG 356

  Fly   380 RPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHR 444
            ...:|..||..::|.||....|. |.:|:|.|...::.:.|.|.:.:|      ..:|...:...
Mouse   357 TREDGLRIVEKMQGRRYHGVTGL-VVMDKNNDRETDFVLWAMGDLDSG------DFQPAAHYSGA 414

  Fly   445 NSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGF-----GGEKCVNYTGEISAAIAGGALL 504
            ...:....:           ||.||.|..|...|.|.|     ..:|....|..|.|...|...:
Mouse   415 EKQIWWTGR-----------PIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFI 468

  Fly   505 LLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPL 569
            :..:.|.:::|....|:||.|:||:|.:.|:|...::|..:....          ||    |..|
Mouse   469 MFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGS----------RL----TLSL 519

  Fly   570 IRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNIC 634
            ..:|..||.:   |..:| .||...|.:||.:.|||.|.||.:::||::..|||.:||.:.:::.
Mouse   520 RGSSYGSLMT---AHGKY-QIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLT 580

  Fly   635 AFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGAL 699
            .|||||.|||||||::|||.||||:|||||:.:.||.||..|::.|:::|:.:||:|.|..||:|
Mouse   581 RFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSL 645

  Fly   700 CTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQR 764
            .:|||:||||:|:|:||:||.:|:...|   .|..|  |...|.|:.|||||...|.. ..|.|:
Mouse   646 KSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSH--ALYAKKLWTAPELLSGNPLP-TTGMQK 704

  Fly   765 GDAYSFGILLYEMHVRRGPFGETG--LTPMQCLQKVLQPQDYLNPY-RPSLQPLETAFDCVSECL 826
            .|.|||.|:|.|:.:|.|||...|  |:|.:.:|||...|   .|| |||:...:...:.|. .:
Mouse   705 ADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQ---RPYFRPSIDRTQLNEELVL-LM 765

  Fly   827 RECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKT 891
            ..|||:.|.:||||..|:..:|...|....:|.||::..||:||||||.||::||....|||:|.
Mouse   766 ERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKA 830

  Fly   892 DALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDS 956
            :|||:::||..||:|||:|..|..|.::.|:|||||||||||:|||.||:|||..|||||||||:
Mouse   831 EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDA 895

  Fly   957 IIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGI 1021
            ||.::|||||||||||||||||||.|||..||.|||.|:|.||.|||.|:|||||.::|.||||:
Mouse   896 IIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV 960

  Fly  1022 HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISM 1086
            |:||||||||||||||||||||||||||||||:|..||||.|...:..||.||.:....||.:.|
Mouse   961 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025

  Fly  1087 KGKGDQRTYWLLGEDE 1102
            ||||..||||||||.:
Mouse  1026 KGKGKMRTYWLLGEQK 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	100/429 (23%)
		ANF_receptor	67..416	CDD:279440	91/378 (24%)
		PK_GC-A_B	570..853	CDD:270944	123/285 (43%)
		TyrKc	597..847	CDD:197581	114/252 (45%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	134/191 (70%)
		Guanylate_cyc	913..1099	CDD:278633	131/185 (71%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607	100/438 (23%)
		PK_GC-A_B	518..792	CDD:270944	124/287 (43%)
		HNOBA	<798..846	CDD:369471	25/47 (53%)
		CYCc	825..1009	CDD:214485	130/183 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720