Protein Alignment CG10738 and ADCY4

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001185497.1
• Gene: ADCY4 / 196883
• HGNCID: 235
• Length: 1077
• Species: Homo sapiens
• Alignment Length: 1297
• Identity: 274/1297 - (21%)
• Similarity: 429/1297 - (33%)
• Gaps: 445/1297 - (34%)

  Fly     5 PCPAPAGN------YHSGLLHPLLLLLF---------LLAFS-----------NFRPT-----HG 38
            |.|.|:.:      |.....:||||||.         |||.:           :|..|     .|
Human     7 PRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGG 71

  Fly    39 EVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHS---------------- 87
            ....||..:..||..   .:.||   :||.:.:|        |...||:
Human    72 FSLLLGLASREQRLQ---RWTRP---LSGLVWVA--------LLALGHAFLFTGGVVSAWDQVSY 122

  Fly    88 LQFVVAETYGEEVVSIRQTAALWTQQ-------VAAYIGPQETCVHEGRMAAAFNLPMIS----- 140
            ..||:...|....:.:|..|......       :..|:|||.    :.|.|.   ||.::
Human   123 FLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQP----DSRPAL---LPQLAANAVL 180

  Fly   141 YYC------THRDPSNKADFPTFART-------RPPDTQISKSVVALLLAFNWTQVSFLYLDDAS 192
            :.|      .|:....:|...||...       |..||: .|....|||:     :...||
Human   181 FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTE-KKHQEHLLLS-----ILPAYL---- 235

  Fly   193 GQYQPVAETILSTLTDAGVSIRDIRTWNTIY---HHG----FMD-----------NPFEAL---- 235
             ..:..||.:.......|........::::|   |.|    :.|           :|.|.:
Human   236 -AREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLN 299

  Fly   236 --------VEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYL 292
                    :.:.:...||.::...||...||.:||....|    :...:|:|:     .:..:.|
Human   300 ELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAI----NCVRMGLDM-----CRAIRKL 355

  Fly   293 RGLLLEDVE-PLAVQAFQSYLGIVPTASVSFATFANEVN--KYMERPPFNFPNPLGPFGGVK-QI 353
            |.....|:. .:.|.:.....|::......:..::::|.  .:||.            |||. ::
Human   356 RAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEA------------GGVPGRV 408

  Fly   354 SAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYI---------DEN 409
            ....|.|......||     |.|:|...|:           .|...:|...|:         ||.
Human   409 HITGATLALLAGAYA-----VEDAGMEHRD-----------PYLRELGEPTYLVIDPRAEEEDEK 457

  Fly   410 GDAAGNYTVL----ARGSVRNGRNQTVLG-LRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWV 469
            |.|.|..:.|    .|.|:...|.....| .:|.....|.:|.:|: |..||.:.|..|| ..|
Human   458 GTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVST-STPLPEKTLASFS-TQW- 519

  Fly   470 GGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWR-YEQELDSLLWKIDFR 533
                                                    ||...|..| .:.|||:    .|.:
Human   520 ----------------------------------------SLDRSRTPRGLDDELDT----GDAK 540

  Fly   534 EVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYK 598
            ..|:.|....|:..||::.                                      |.|:.||
Human   541 FFQVIEQLNSQKQWKQSKD--------------------------------------FNPLTLY- 566

  Fly   599 GQLYAIKKVRKKSVDITREMKKELKL--LRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDI 661
                    .|:|      ||:||.:|  :...::...|.|:
Human   567 --------FREK------EMEKEYRLSAIPAFKYYEACTFL------------------------ 593

  Fly   662 LENEDVKLDNMFIASMVAD------IIRGVIYLHDSPIRFHGALCTS----NCLVDS----RWVV 712
                 |.|.|..|..:|.:      |...:.:|....|.|   :|.|    .|::..    .|:.
Human   594 -----VFLSNFIIQMLVTNRPPALAITYSITFLLFLLILF---VCFSEDLMRCVLKGPKMLHWLP 650

  Fly   713 KLTDFGLFAFKQGIE---DSSTDMQHMSAKCLKLL---------YRAPELLRQGPSSLVMGTQRG 765
            .|:  ||.|.:.|:.   .::|.:...:.....|.         ::||.:     ||::......
Human   651 ALS--GLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNV-----SSMISNLSWE 708

  Fly   766 DAYSFGILL--YEMHVRRGPFGETGLTPMQCLQKVLQPQDYLN---PYRPSLQPLETAFDC---- 821
            ...|..::.  |.||.              |....|....:|:   ..:..|..|..|..|
Human   709 LPGSLPLISVPYSMHC--------------CTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFL 759

  Fly   822 -----VSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDN-----------------MMA 864
                 :||||               .:|..|.||  ..||.:...                 ::|
Human   760 HSHAWLSECL---------------IVRLYLGPL--DSRPGVLKEPKLMGAISFFIFFFTLLVLA 807

  Fly   865 MMEKYANNLEALVDDRTDQLQEE----KKKTDALLHEMLPRCVADQL----KKGHKVDPEHYEQV 921
            ...:|...|:.|...:..|.:||    :..|..||..:||..||.|.    ::...:..:.||.|
Human   808 RQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECV 872

  Fly   922 SIYFSDIVGFTAMSAECT----PLQVVDFLNDLYTCFDSIIG---HYDVYKVETIGDAYMVVSGL 979
            .:.|:.:..|....:|..    .|:.:..||::...||.::.   ...|.|::|||..||..:||
Human   873 CVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGL 937

  Fly   980 PLRNGDLHAAEIATMSLHLLSAVSEFK---------IRHRPTNRLLLRIGIHSGPVCAGVVGLKM 1035
            ...:|. .|.:.|..|...|..:.||.         |.....|...||:|::.|||.|||:|.:.
Human   938 NATSGQ-DAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQK 1001

  Fly  1036 PRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWL 1097
            |:|.::|:|||.||||||:||..||..:.:....|..| ||....||||.:||||...||:|
Human  1002 PQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL-GYTCYSRGVIKVKGKGQLCTYFL 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	92/488 (19%)
		ANF_receptor	67..416	CDD:279440	79/432 (18%)
		PK_GC-A_B	570..853	CDD:270944	56/324 (17%)
		TyrKc	597..847	CDD:197581	50/291 (17%)
		HNOBA	<862..907	CDD:285003	14/48 (29%)
		CYCc	886..1078	CDD:214485	69/215 (32%)
		Guanylate_cyc	913..1099	CDD:278633	70/201 (35%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831	29/148 (20%)
		CYCc	219..422	CDD:214485	39/234 (17%)
		Guanylate_cyc	264..418	CDD:278633	30/174 (17%)
		DUF1053	479..583	CDD:283888	37/203 (18%)
		CYCc	827..1042	CDD:214485	68/216 (31%)
		Guanylate_cyc	864..1063	CDD:278633	70/201 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810