DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-23

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1230	Identity:	331/1230 - (26%)
Similarity:	538/1230 - (43%)	Gaps:	313/1230 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLLFLLAF---SNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAI--SLAVEEVNAGRLR 82
            |.:|||..   :|.:...|.:..:|.:..:::   .|..::..||..|.:  ...:|.:|
Worm     5 LFIFLLLLGECANVKVKVGHIGAVGSMRNAEK---ILQLSKEQLTQEGVLGNDFDIEILN----- 61

  Fly    83 DRGHSLQFVVAETY-----GEEVVSIRQTAALWTQQVAAYIGPQETCVHE----GRMAAAFNLPM 138
                  |....|:|     |.::..:        |.|.|:|||.  |..|    .:||..:|:|:
Worm    62 ------QMGCGESYEGVAVGADMYHV--------QGVRAFIGPY--CNAELDAVAKMATFWNIPV 110

  Fly   139 ISYYCTHRDPSNKADFPTFARTRPPDT-QISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETI 202
            :.|..:....::|..|.|.||.....| .::::..||:..:.|.:|:
Worm   111 VGYMASSNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVA------------------ 157

  Fly   203 LSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGI 267
            ::|.|.| |:...::::..::|                                       :|||
Worm   158 IATNTGA-VAFERVQSFEEVFH---------------------------------------QRGI 182

  Fly   268 LSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLA---VQAFQS------------------- 310
                 ..|..|.:|:|..||  ..:...||:::|..|   |.||.|
Worm   183 -----NVVRKIMLEEYTNAK--AIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMNN 240

  Fly   311 --YLGIVPTASV---SFATFANEVNKYMERPPFNFPNP-------------LGPFGGVKQISAEA 357
              |..|:|...:   ..|.:..|..:|.:....:|.|.             :.||....:.|..:
Worm   241 ANYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDNTLVTPFKERLEASGYS 305

  Fly   358 A------------YLYDAVHLYAKALMEVLDSGGRPR---NGSAIVAAIKGSRY----------- 396
            .            :||||:.|||.|:...::..|...   ||..:...::...:
Worm   306 TDDLEMKNIYGYIHLYDALRLYALAVRATMNETGNENSYLNGKEVWNHMRRITFPGLVSNAGVTS 370

  Fly   397 ----------RSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPV------------G 439
                      |:.:....|:..|.|           :||.     |..|.||            |
Worm   371 GTVMMDDIAERAPVYAAFYVPPNSD-----------TVRK-----VCELEPVMLTNCDGTKTGNG 419

  Fly   440 TFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALL 504
            .:..:.:.||:          ..:..||   |:.||..|.|||..||| :||    ..|.||.::
Worm   420 CYELQVTDLST----------GFWPSID---GSLPADEPACGFRNEKC-DYT----TLIIGGCIV 466

  Fly   505 LLSLVSLVLY-------RNWRYEQELDSLLWKI---DFREVQIHENEREQQ----SQKQTRHLLN 555
            ||.::.::.:       .|    :.|.:..|:|   |||.:|  |||.:..    |.|.....::
Worm   467 LLIILLIICFFILSRVCEN----RALANTPWRIYRDDFRTIQ--ENEMKSMLSIGSSKTKMSNMS 525

  Fly   556 HLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKK 620
            ...:.      |.::.|       |..|.|              .||.    :::.:...|:..:
Worm   526 MFVKH------HAVVGT-------NTHASF--------------HLYP----QRRPIVFNRQDLQ 559

  Fly   621 ELKLLRDARHDNICAFIG-ACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRG 684
            .|..::.|.|||:..|:| :..:...:.::.::|:||:::|::.|::|.||:.|..:.:.||..|
Worm   560 LLNQMKQAVHDNLNPFLGMSFNEKEEMVVLWKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLG 624

  Fly   685 VIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFA-----FKQGIEDSST----DMQHMSAKC 740
            :.|||.|.|.:||:|...:||:|..|::||||:|:..     .|.|:..:.|    |.:..||:.
Worm   625 LEYLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQK 689

  Fly   741 LKLLYRAPELLRQGPSSLV------------MGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQ 793
            ..|||:.||:|:...|:..            ...|.||.|:||::::|:..|..|| ..|....:
Worm   690 TSLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRALPF-PNGTNVSE 753

  Fly   794 CLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNI 858
            .:..:   :|....:||::.........:...|.:||.|.||.||..:.:|.......| ::.::
Worm   754 VMDYI---RDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNTENYLK-VKGSL 814

  Fly   859 FDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSI 923
            .|.||.|||:||||||.||.:||..|:|...:.|.||.::||:.||::||.|..|..:.::..::
Worm   815 VDQMMRMMEQYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATV 879

  Fly   924 YFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHA 988
            .||||||||.:.:..|||:||..||.:|:.||..|..:..|||||||||||:|||:|..||:.|.
Worm   880 MFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHI 944

  Fly   989 AEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMES 1053
            ..|...:|.|:..:..::|.||...:|.:|:|||:|.|.||||||..|||||||||||.||||||
Worm   945 RNICNTALELMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMES 1009

  Fly  1054 SGVPLKIHCSWQCRQLLDRLGGYHFAE-----RGVISMKGKGDQRTYWLLGEDEEARTRR 1108
            :..|.||..|.:.|....|    :::|     ||.:..||||...:|||||:..|::.::
Worm  1010 TSEPEKIQMSQEARDFCVR----YYSEFQITLRGTVEAKGKGPVTSYWLLGKQSESQMQQ 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	89/499 (18%)
		ANF_receptor	67..416	CDD:279440	78/436 (18%)
		PK_GC-A_B	570..853	CDD:270944	79/304 (26%)
		TyrKc	597..847	CDD:197581	75/271 (28%)
		HNOBA	<862..907	CDD:285003	24/44 (55%)
		CYCc	886..1078	CDD:214485	91/191 (48%)
		Guanylate_cyc	913..1099	CDD:278633	90/190 (47%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	86/470 (18%)
		ANF_receptor	38..385	CDD:279440	78/432 (18%)
		PK_GC	509..806	CDD:270894	82/331 (25%)
		HNOBA	<817..863	CDD:285003	24/45 (53%)
		CYCc	842..1035	CDD:214485	92/196 (47%)
		Guanylate_cyc	869..1056	CDD:278633	90/190 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910