Protein Alignment CG10738 and gcy-23

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_500309.3
• Gene: gcy-23 / 191652
• WormBaseID: WBGene00001548
• Length: 1073
• Species: Caenorhabditis elegans
• Alignment Length: 1230
• Identity: 331/1230 - (26%)
• Similarity: 538/1230 - (43%)
• Gaps: 313/1230 - (25%)

  Fly    23 LLLFLLAF---SNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAI--SLAVEEVNAGRLR 82
            |.:|||..   :|.:...|.:..:|.:..:::   .|..::..||..|.:  ...:|.:|
 Worm     5 LFIFLLLLGECANVKVKVGHIGAVGSMRNAEK---ILQLSKEQLTQEGVLGNDFDIEILN----- 61

  Fly    83 DRGHSLQFVVAETY-----GEEVVSIRQTAALWTQQVAAYIGPQETCVHE----GRMAAAFNLPM 138
                  |....|:|     |.::..:        |.|.|:|||.  |..|    .:||..:|:|:
 Worm    62 ------QMGCGESYEGVAVGADMYHV--------QGVRAFIGPY--CNAELDAVAKMATFWNIPV 110

  Fly   139 ISYYCTHRDPSNKADFPTFARTRPPDT-QISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETI 202
            :.|..:....::|..|.|.||.....| .::::..||:..:.|.:|:
 Worm   111 VGYMASSNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVA------------------ 157

  Fly   203 LSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGI 267
            ::|.|.| |:...::::..::|                                       :|||
 Worm   158 IATNTGA-VAFERVQSFEEVFH---------------------------------------QRGI 182

  Fly   268 LSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLA---VQAFQS------------------- 310
                 ..|..|.:|:|..||  ..:...||:::|..|   |.||.|
 Worm   183 -----NVVRKIMLEEYTNAK--AIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMNN 240

  Fly   311 --YLGIVPTASV---SFATFANEVNKYMERPPFNFPNP-------------LGPFGGVKQISAEA 357
              |..|:|...:   ..|.:..|..:|.:....:|.|.             :.||....:.|..:
 Worm   241 ANYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDNTLVTPFKERLEASGYS 305

  Fly   358 A------------YLYDAVHLYAKALMEVLDSGGRPR---NGSAIVAAIKGSRY----------- 396
            .            :||||:.|||.|:...::..|...   ||..:...::...:
 Worm   306 TDDLEMKNIYGYIHLYDALRLYALAVRATMNETGNENSYLNGKEVWNHMRRITFPGLVSNAGVTS 370

  Fly   397 ----------RSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPV------------G 439
                      |:.:....|:..|.|           :||.     |..|.||            |
 Worm   371 GTVMMDDIAERAPVYAAFYVPPNSD-----------TVRK-----VCELEPVMLTNCDGTKTGNG 419

  Fly   440 TFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALL 504
            .:..:.:.||:          ..:..||   |:.||..|.|||..||| :||    ..|.||.::
 Worm   420 CYELQVTDLST----------GFWPSID---GSLPADEPACGFRNEKC-DYT----TLIIGGCIV 466

  Fly   505 LLSLVSLVLY-------RNWRYEQELDSLLWKI---DFREVQIHENEREQQ----SQKQTRHLLN 555
            ||.::.::.:       .|    :.|.:..|:|   |||.:|  |||.:..    |.|.....::
 Worm   467 LLIILLIICFFILSRVCEN----RALANTPWRIYRDDFRTIQ--ENEMKSMLSIGSSKTKMSNMS 525

  Fly   556 HLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKK 620
            ...:.      |.::.|       |..|.|              .||.    :::.:...|:..:
 Worm   526 MFVKH------HAVVGT-------NTHASF--------------HLYP----QRRPIVFNRQDLQ 559

  Fly   621 ELKLLRDARHDNICAFIG-ACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRG 684
            .|..::.|.|||:..|:| :..:...:.::.::|:||:::|::.|::|.||:.|..:.:.||..|
 Worm   560 LLNQMKQAVHDNLNPFLGMSFNEKEEMVVLWKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLG 624

  Fly   685 VIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFA-----FKQGIEDSST----DMQHMSAKC 740
            :.|||.|.|.:||:|...:||:|..|::||||:|:..     .|.|:..:.|    |.:..||:.
 Worm   625 LEYLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLISTETLKEGDDKSGSAQK 689

  Fly   741 LKLLYRAPELLRQGPSSLV------------MGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQ 793
            ..|||:.||:|:...|:..            ...|.||.|:||::::|:..|..|| ..|....:
 Worm   690 TSLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFGMVMHEILFRALPF-PNGTNVSE 753

  Fly   794 CLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNI 858
            .:..:   :|....:||::.........:...|.:||.|.||.||..:.:|.......| ::.::
 Worm   754 VMDYI---RDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNTENYLK-VKGSL 814

  Fly   859 FDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSI 923
            .|.||.|||:||||||.||.:||..|:|...:.|.||.::||:.||::||.|..|..:.::..::
 Worm   815 VDQMMRMMEQYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATV 879

  Fly   924 YFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHA 988
            .||||||||.:.:..|||:||..||.:|:.||..|..:..|||||||||||:|||:|..||:.|.
 Worm   880 MFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHI 944

  Fly   989 AEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMES 1053
            ..|...:|.|:..:..::|.||...:|.:|:|||:|.|.||||||..|||||||||||.||||||
 Worm   945 RNICNTALELMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMES 1009

  Fly  1054 SGVPLKIHCSWQCRQLLDRLGGYHFAE-----RGVISMKGKGDQRTYWLLGEDEEARTRR 1108
            :..|.||..|.:.|....|    :::|     ||.:..||||...:|||||:..|::.::
 Worm  1010 TSEPEKIQMSQEARDFCVR----YYSEFQITLRGTVEAKGKGPVTSYWLLGKQSESQMQQ 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	89/499 (18%)
		PK_GC-A_B	570..853	CDD:270944	79/304 (26%)
		HNOBA	<860..907	CDD:462234	25/46 (54%)
		CYCc	886..1078	CDD:214485	91/191 (48%)
gcy-23	NP_500309.3	PBP1_NPR_GC-like	30..407	CDD:380575	86/481 (18%)
		PK_GC	509..806	CDD:270894	82/331 (25%)
		CYCc	842..1035	CDD:214485	92/196 (47%)