DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-19

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	1263	Identity:	348/1263 - (27%)
Similarity:	539/1263 - (42%)	Gaps:	232/1263 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLFLLAFSNF-----------RPTHGEVFTLGYLTASQR--RPG-----NLDYNRPGLTIS-GAI 69
            |||||.|:.|           :.|.....|.....|::|  |.|     ..:.:..|..:| |||
Worm     4 LLFLLLFAGFLTFLPRFLIYAQITSSTTTTTPVPAANRRTIRVGVAAVQTTELDSIGWPMSGGAI 68

  Fly    70 SLAVEEVNAGRLRDRGH--SLQFVVAETYGEEVVSIRQTAA---LWTQQVAAYIGP--QETCVHE 127
            ::|::     :|||.|.  ...|.|...|.|...|:.....   :.|:::...|||  ::.....
Worm    69 NMAIQ-----KLRDDGFIAPFDFEVTVNYTECDRSLGAAVGMEFMRTKRLDVVIGPPCRDPMEIM 128

  Fly   128 GRMAAAFNLPMISY-YCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDA 191
            ..||..::.||:.: ..|....::...:|...........:..|:|.||....|.:|:.:|  :.
Worm   129 ATMATYYSTPMLGWGLVTDSKFTDTERYPYLTNIMANSLSLGFSLVKLLEMMEWDRVALVY--EE 191

  Fly   192 SGQYQPVAETILSTLTDAGVSIRDIRTW--NTIYHHGFMDNPFE------------------ALV 236
            |.|..|     ||.:.|...:|.:..|:  |.:...........                  ..|
Worm   192 SAQDYP-----LSVINDVETAINEYDTFAVNVVVKQALPGGDLNDAQYISVLNRIKLRCRIIVSV 251

  Fly   237 EQTYANTRIYLILGHYY-----EHVGLMVSLQRRGI------LSKGDYFVVGIDIEQYDPAKPEK 290
            .||....|.||.:....     |:|.:::.|:..|.      |:|.:...:...:..:....|:.
Worm   252 FQTAPTRRRYLKMIDQQGMANEEYVHILLGLRSIGFGKQSAGLTKCELNCLSSGLAPFWDIAPDD 316

  Fly   291 YLRGLLLEDVEPLAVQAFQSYLGI---VPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQ 352
            .|...|.:....:.|......:.:   ||..:. ..||.......:..||.:...|.........
Worm   317 GLNDRLKQAATRMLVMDLPDTMDLSTDVPDINY-LNTFTMNCGAVVVNPPVSCATPACINASTSP 380

  Fly   353 ISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDE-NGDAAGNY 416
            .||.|..|:|..:||..|:..:                     |.....|...||: ||....|:
Worm   381 PSAFARSLHDVFYLYGLAITNL---------------------YNQDPAYLNDIDKINGALQLNF 424

  Fly   417 TVLARGSVRNGRNQTVLGLR--------PVGTFIHRNSSL---SSISKALPHQNLKLFSPIDWVG 470
            ..|......|..|..|..|.        ...:|::...||   :|:|.|..::....:    |.|
Worm   425 AGLTGEVSINANNSRVPKLMLYALNDKYDQASFMNLTYSLNGGASVSLAYTNEASLWY----WYG 485

  Fly   471 GTRPAAAPRCGFGGEKC----VNYTGEISAAIAGGALL--LLSLVSLVLY--RNWRYEQELDSLL 527
            |.||.:.|.|||.|..|    |:..|.:..|| ||.|:  :|.:::...|  |..|.|::.....
Worm   486 GKRPLSVPVCGFAGTDCPQSFVDQYGALVFAI-GGVLIFAMLFVITCFFYVMRQKRLERDRIDAE 549

  Fly   528 WKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPD-----ADFRY 587
            |:|...::|                        .||:....  |.|:.||.|.|.     :...:
Worm   550 WQIPLVKLQ------------------------APPKRDKE--RMSKRSLQSGPSNITDTSKMTF 588

  Fly   588 TTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEY 652
            ...|:...::......:......:.::.|........||...|:|:..|:|...|.|....:.:.
Worm   589 DNTFSNYSIFYLDKEPVLSTAHPASNLIRTDYDTFVRLRKLDHENVNKFVGMSIDGPEYLAVWKL 653

  Fly   653 CTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDF 717
            |.||||:||:...:..:|..|:..::.|:..|:.|||:|.:..|..|.:...||:..|..|||||
Worm   654 CMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKYLHNSFLHVHANLRSGTVLVNESWQAKLTDF 718

  Fly   718 GLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGT-------QRGDAYSFGILLY 775
            ||..    :.:....|:.      :.|:.|||::|        ||       :..|.||..::..
Worm   719 GLGT----LAEEKKPMKR------RQLWMAPEVIR--------GTLLPHQIEKSADIYSLAVIAS 765

  Fly   776 EMHVRRGPF--GETGLTPMQCLQKVLQ--PQDYLNPYRPSLQPLETAFDCVS------ECLRECW 830
            |:..|:..:  .|...|..:.:.::.:  |    |..||.|.     .|.|.      ..:|:||
Worm   766 EVLTRKEAWNMAERKDTVDEIVYRIKKGGP----NAPRPELD-----MDGVEINHNLLILIRDCW 821

  Fly   831 AERPEDRPDFKTIRTKLRPL--RKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDA 893
            :|.|.|||....|...|:.:  :||   |:.|::..::|.|..|||..|:|||.:|..||||.|.
Worm   822 SEEPADRPSADVICNLLKNMMPKKG---NLMDHVFNILEDYTTNLEVEVEDRTKELTAEKKKADV 883

  Fly   894 LLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSII 958
            ||..|||:.||::||:|..|:||.::.|:::|||:|.||.::|:|:|.|||:.|||||:.||:||
Worm   884 LLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDAII 948

  Fly   959 GHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHS 1023
            ..:..||||:|||.|:.|||||.:||:.|..:|..:||..:|....|||.|.|..::.||||::|
Worm   949 EEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNS 1013

  Fly  1024 GPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDR--LGGYHFAERGVISM 1086
            ||..||||||.|||||||||||||||||||:|....||.|.....||.:  ...|:.|.||.:.:
Worm  1014 GPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKHYPNQYNTASRGDVII 1078

  Fly  1087 KGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLP 1151
            ||||...|:|:            :||:        |:|: |.       ::..|.:|..|..|
Worm  1079 KGKGVMETFWV------------FERN--------NQFM-GV-------SSNSGYQSDKKATN-- 1113

  Fly  1152 RNSLTRSSSLESPKKLRFAAGSLLEHHR 1179
            ..|...|:...:|......|.|.:.|.:
Worm  1114 NGSSPESTPPSTPPMHEVKANSPVRHRK 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	89/458 (19%)
		ANF_receptor	67..416	CDD:279440	76/391 (19%)
		PK_GC-A_B	570..853	CDD:270944	75/306 (25%)
		TyrKc	597..847	CDD:197581	67/266 (25%)
		HNOBA	<862..907	CDD:285003	22/44 (50%)
		CYCc	886..1078	CDD:214485	104/193 (54%)
		Guanylate_cyc	913..1099	CDD:278633	98/187 (52%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	89/455 (20%)
		PKc_like	571..841	CDD:328722	73/296 (25%)
		CYCc	876..1065	CDD:214485	103/188 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910