DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-17

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	1133	Identity:	348/1133 - (30%)
Similarity:	537/1133 - (47%)	Gaps:	172/1133 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 TISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTA-ALWTQQVAAYIGPQETCVHE 127
            |.:.|:.:...::....:.| |...:|:.......|::...:|. .|..::|....||  ||...
Worm    45 TSAAAVLVTKNKIREDHVLD-GFDFEFLWDFDECNEILGAGKTVDLLEVKKVDVIFGP--TCSRP 106

  Fly   128 GRMAAA----FNLPMISYYCTH-RDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLY 187
            ..:::|    :|:|:..:..|. |..::...|||..........::.:::..|..|.||:..|||
Worm   107 ALISSALATYYNIPIFEWGLTSTRQLTDVKRFPTTLPFSVNSYSLAMAILGTLKQFQWTEFVFLY 171

  Fly   188 LDDASGQ----YQPVAETILST----------------LTDAGVSIRDIRTWNTIY------HHG 226
            .:|...:    .:...:|:.|.                |.|...:|.:|:....|.      .:|
Worm   172 CNDGDDEKCESLKDDVQTVASAHEELSLAYTFRIQSKKLEDMRAAIVEIKKRGRIIVACVASGNG 236

  Fly   227 FMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGIL-----SKGDYFVVG--IDIEQYD 284
            ......:|:..:...|:          |:|.:|.....||.:     .|..|...|  .|.:.:.
Worm   237 SKRTLMQAVALENANNS----------EYVYIMAETNSRGFVVEEVGGKWHYLWEGKFDDSDTFS 291

  Fly   285 PAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFN-FPNPLGPFG 348
            .......:..||.          ....:|:....:..:..|:..|.:.|:..||| ..:.:|
Worm   292 TEDSRTSMANLLF----------LVDNMGMNNVVTPQYLNFSKNVIEMMKDEPFNCVEDCVG--- 343

  Fly   349 GVKQISAEAAY---LYDAVHLYAKALMEVLDSGGRP--RNGSAIVAAIKGSRYRSAMGYHVYIDE 408
              ::.|:.|.|   |.||.:.||.|:..:|.:..:.  |||:.|:..| |..:....|..:.:|.
Worm   344 --EEYSSVAKYAGQLADAFYAYAVAVNRLLTANPQAEIRNGTMILRNI-GMTFEGVGGGDLTVDP 405

  Fly   409 NGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPID-WVGGT 472
              |:|....::..|...:...:|      .|..|..|.|:.       .:.|.....:| |.|..
Worm   406 --DSARTSEIIMIGLNSSRLPET------YGKLIINNQSVH-------FEQLYSDEVMDVWNGRQ 455

  Fly   473 RPAAAPRCGFGGEKC-VNYTGEISAAIAGGALLLLSLVS----LVLY--RNWRYEQELDSLLWKI 530
            ||.|.|.|||.|.:| .::..:....:....:.|:..||    .|.|  |..|.|.|....||.:
Worm   456 RPKAKPTCGFTGTQCPPDFVRDYLVIVIIIVMFLIFAVSAAVGAVFYAIRQKRKEIERQDELWHV 520

  Fly   531 DFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTT------ 589
            :                      .:|    |.|.|.......||.|.:|.|....:.|.
Worm   521 E----------------------ASH----LKPISKKSKSEASQRSFASGPSTSTKLTVESRTET 559

  Fly   590 ---IFTPIGLYKGQLYAIKK--VRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICII 649
               ||....:...::.|..|  .|.:..|:.|   .||:.:|...|||:..|||.|.:...:..|
Worm   560 TRFIFYIYQVRNNEVVAANKHDFRPQLTDVER---SELRQMRSLDHDNLNKFIGLCLNSQQLLSI 621

  Fly   650 SEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKL 714
            ..||:||||.|::....:::|:.|:.|::.||..|:.::|.|.:.|||.|.:.:||:|.||.||:
Worm   622 WRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDRWQVKI 686

  Fly   715 TDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHV 779
            :||||...: |::..||:         .:|:.|||:||    .|...::..|.|||||:..|:..
Worm   687 SDFGLNEVR-GMDKLSTE---------NMLWWAPEVLR----GLEQRSKEADIYSFGIICSEVIT 737

  Fly   780 RRGPFGETGLTPMQCLQKVLQPQDYL--------NPYRPSL---QPLETAFDCVSECLRECWAER 833
            |...|        ....:..:|::.:        |..||||   :.||.. ..:...:|:||.|:
Worm   738 RSSAF--------DLENRKEKPEEIIYQLKKGGFNAIRPSLLTDEALEIN-PALVHLIRDCWTEK 793

  Fly   834 PEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEM 898
            |.:||....:|:.||.:..|.:.|:.|::..|:|.||:.||..|::||.:|.||:||:|.||:.|
Worm   794 PSERPPIDQVRSLLRGMNDGKKGNLMDHVFNMLETYASTLEEEVNERTKELVEEQKKSDVLLYRM 858

  Fly   899 LPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDV 963
            ||:.||::||.|..::||.:|.|:|:|||:|.||.::::|||||||..||||||.|||||...||
Worm   859 LPKTVAEKLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDV 923

  Fly   964 YKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCA 1028
            ||||||||.|:.|||||.|||..|...||.|||..||:::||::.|.|:.|:.|||||:.|.|.|
Worm   924 YKVETIGDGYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGSVVA 988

  Fly  1029 GVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDR-LGGYHFAERGVISMKGKGDQ 1092
            |||||.|||||||||.|||||||||:|.|.:||.|.:...||.. :||:...|||.:.:||||..
Worm   989 GVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEERGEVIIKGKGVM 1053

  Fly  1093 RTYWLLGEDEEARTRRTYERSQRRGSRA 1120
            .|||||||::....:....:.:...|.|
Worm  1054 NTYWLLGENDSVPVKSNMRKRENTPSMA 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	81/421 (19%)
		ANF_receptor	67..416	CDD:279440	77/393 (20%)
		PK_GC-A_B	570..853	CDD:270944	91/304 (30%)
		TyrKc	597..847	CDD:197581	81/262 (31%)
		HNOBA	<862..907	CDD:285003	22/44 (50%)
		CYCc	886..1078	CDD:214485	116/192 (60%)
		Guanylate_cyc	913..1099	CDD:278633	112/186 (60%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141	75/387 (19%)
		ANF_receptor	47..398	CDD:279440	73/379 (19%)
		PKc_like	539..808	CDD:304357	87/294 (30%)
		Pkinase	567..803	CDD:278497	80/261 (31%)
		HNOBA	<824..867	CDD:285003	22/42 (52%)
		CYCc	846..1038	CDD:214485	116/191 (61%)
		Guanylate_cyc	873..1060	CDD:278633	112/186 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229634at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920