DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-15

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	1180	Identity:	380/1180 - (32%)
Similarity:	568/1180 - (48%)	Gaps:	188/1180 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 ISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAA 133
            :.:|:..:||.:..:..|.|.....:|.........:||||....||| :|....|..:..: ..
Worm     1 MEIAINRLNADKDLEVFHDLDVNYVDTSKTAGPRAARTAALNNATVAA-MGLMRDCYIQSTI-LN 63

  Fly   134 FNLPM-ISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQP 197
            .||.: :|..|.....|.|....|..........::|||:..|..:.|.:|:   |...|.....
Worm    64 INLKIAVSDVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVA---LVSPSAVLTA 125

  Fly   198 VAETILSTLTDAGVSIR-DIRTWNTIYHHGFMDNPFEAL------VEQTYANTRIYLI------- 248
            .|..:.|.|.||..:.: ||          .:|:..:.:      |::.....||::|
Worm   126 FAARVRSDLLDALTANKIDI----------LVDSRLDPMSDITEKVKEDAEKARIFIICDWSSNA 180

  Fly   249 --LGHYYEHVGLMVSLQRRGILSKGDYFVVGI-------------------------DIEQYDPA 286
              |.:|...:|.|..:|      .|:|||:|.                         ||..|:..
Worm   181 NLLRNYIFKLGEMNKMQ------SGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLT 239

  Fly   287 K---PEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFG 348
            :   .|.|...::|.|..|.|          .|.     :|:.:...:.:::.|.....|.....
Worm   240 ENDLHEVYKNVVILSDGPPPA----------EPN-----STWEDIKTQVLKKKPAKMCPPYCNTT 289

  Fly   349 GVKQISA---EAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENG 410
            ..::|:.   ....|:|::...|.|..:.|:.|............:...:..|..|...|||..|
Worm   290 ISEKITPRWDRIKLLFDSIQYLADATNDALNIGANIYQSDIFYEHLISRKVDSVTGVTEYIDGYG 354

  Fly   411 DAAGNYTV-------------------LARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALP 456
            ...|:..:                   ||:.|:.|    ||.             ||:..|:.|
Worm   355 AIVGSMQIYYHFSSSSHNSYSLFPCARLAQSSLLN----TVW-------------SLTDYSEGL- 401

  Fly   457 HQNLKLFSPIDWVGGTRPAAAPRCGFGGEKC---VNYTGEISAAIAGGALLLLSLVSLVLYRNWR 518
                    .||:|..:.|...|.|||.||.|   .|.|..|..::....|:.|::.:..||:.:|
Worm   402 --------SIDFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYR 458

  Fly   519 YEQELDSLLWKIDFREVQI--HENEREQQSQKQTRHLLNHLPRRLPP-QSTHPLIRTSQVSLSSN 580
            ||:.|.||.:.||..::.:  |.|...|||.:....:...:...... :.:|..|.....:.|.|
Worm   459 YERRLHSLFFMIDRNQIILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASSIN 523

  Fly   581 PDADFRYTTI-----FTPI-----------------------GLYKGQLYAIKKVRKKSVDITRE 617
            ..:.|...:.     |.||                       |||:|:..|:|::.:..|:.||.
Worm   524 ASSIFNTGSTARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRIYRSDVEFTRS 588

  Fly   618 MKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADII 682
            .:.|:..|:::.:.|:..|:|.....|::.::.|...||||||||:|:|:.||::|.:.|..|||
Worm   589 NRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDII 653

  Fly   683 RGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIE--DSSTDMQHMSAKCLKLLY 745
            .|:.|||.||:..||.|.::|||:|:||:|:|:.|||...: |.|  ....|:|....:    |:
Worm   654 AGLEYLHSSPVGCHGRLKSTNCLIDARWMVRLSSFGLRELR-GEETWQQEDDVQEGKDQ----LW 713

  Fly   746 RAPELLR--QGPSSL-VMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYL-- 805
            .:|||||  .|.|.. |:..|:.|.||..|:|||:..|.||:|:..:.|.:.:.  |..::.|
Worm   714 TSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVS--LVKREALAG 776

  Fly   806 -NPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKY 869
             .|:||.:..|:.:...|.|.:...|.|.|.:||....|:.||:||..|::..|.|||::|:|||
Worm   777 KKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKY 841

  Fly   870 ANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAM 934
            .:.||..:.:|.::|:.||.|::|||..|||..|||.||.|..|..|.:|..:::|||..||..|
Worm   842 TDKLEKDIAERNEELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEM 906

  Fly   935 SAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLL 999
            ||...|:.:|.|||||||.||.||..:||||||||.|||||.||||:.||:.||.|||::.|.||
Worm   907 SATSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALL 971

  Fly  1000 SAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSW 1064
            .||..|||||.|..::.||||::|||..||||||||||||||||||||||||||:|:||:|:||.
Worm   972 KAVESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSG 1036

  Fly  1065 QCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTI 1129
            ..:::||:||||...|||::.|||||.|.||::.||:.:.|..|..        |...||  .::
Worm  1037 TAKEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGENSDMRRERII--------RERVKF--ASL 1091

  Fly  1130 KQAQEQANEY 1139
            |:||.|...|
Worm  1092 KKAQIQEKTY 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	85/438 (19%)
		ANF_receptor	67..416	CDD:279440	79/394 (20%)
		PK_GC-A_B	570..853	CDD:270944	104/318 (33%)
		TyrKc	597..847	CDD:197581	91/257 (35%)
		HNOBA	<862..907	CDD:285003	21/44 (48%)
		CYCc	886..1078	CDD:214485	119/191 (62%)
		Guanylate_cyc	913..1099	CDD:278633	115/185 (62%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822	79/396 (20%)
		PK_GC	553..822	CDD:270894	95/275 (35%)
		HNOBA	<831..879	CDD:400168	23/47 (49%)
		Guanylate_cyc	885..1071	CDD:306677	115/185 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880