DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-13

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	1117	Identity:	359/1117 - (32%)
Similarity:	545/1117 - (48%)	Gaps:	174/1117 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 TISGAISLAVEEVNAGRLRDRGHSLQFV-VAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHE 127
            |.:.||.:|::.:.:..|.| ...:.|: |.:...|...:...:..|....|:|.:||  ||...
Worm     9 TSASAIEIAMDRIKSEHLID-NIGINFIYVFDDCNEAKAAGLSSKLLMDANVSAIVGP--TCNAA 70

  Fly   128 G----RMAAAFNLPMISYYCTHRDP-SNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLY 187
            |    .:|..:|.|::::..|.... .:.:.:||.....|....|:.::..:::.|.||:..:::
Worm    71 GLAVVNLAGYYNTPVLTWGLTISSSFIDTSKYPTTVTIVPVAKSIAAAIHEVMIQFEWTEFVYVF 135

  Fly   188 LDDAS-GQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALV---EQTYANTRIYLI 248
            ::|.. |.::...|.|.|......:| |.|:    ||     |..:..||   |:....:||:.:
Worm   136 VEDEKCGYFRDDLEQITSDSNYTSLS-RTIQ----IY-----DQSYTNLVRQLEKLKTVSRIFTV 190

  Fly   249 -------------LGHY------YEHVGLMV---SLQRRGILSKGDYFVVGIDIEQYDPAKPEKY 291
                         |..|      .|:|.|..   |...:...|.||...:.:|..:....:.|:
Worm   191 CLPEAGDIKRRFMLAAYDLDMTTDEYVYLFAGPKSTAYQQTSSTGDVVGIWVDWSENPDGRDEE- 254

  Fly   292 LRGLLLEDVEPLAVQAFQSYLGIV--PTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQIS 354
                        |..||...:.||  |.....:|.|..||.:.|:.||:|..:....    |:..
Worm   255 ------------AKLAFMRTMVIVATPVQGEQYAAFKKEVIERMKLPPYNCVDECKE----KEYQ 303

  Fly   355 AEAAY---LYDAVHLYAKALMEVLDSGG--RPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAG 414
            ..|.|   |:|.::|||..|.:.::..|  :..|||.||....|..:....|. |.::..|....
Worm   304 EAAEYADQLHDTIYLYALILNKTIEEQGIEQIANGSNIVTRGAGIEFEGMSGV-VRMNGIGYRLP 367

  Fly   415 NYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPR 479
            |..:....|  |...:||..:....|.:  |.:.:.|.:||..         |...|..|...|.
Worm   368 NMNLANLDS--NATQRTVAYMDIDSTSV--NWTFAIIDQALIW---------DAYNGKLPQTRPE 419

  Fly   480 CGFGGEKC-VNYTGEISAAIAGGALLLL-----SLVSLVLYRNWRYEQELDSLLWKIDFREVQIH 538
            ||:.|:.| ||:..:....:...|::::     :.::..|....|.::||     ::|.:.:..|
Worm   420 CGYSGKSCPVNFFVDYLYIVVIVAVIIVLCCAAAAIAAFLVIKARRDEEL-----RLDDQWIVPH 479

  Fly   539 ENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSN----PDADFR--YTTIFTPIGLY 597
               ...||..:.|...:|..|.|...||   ..|....:||.    |:.:.:  :..:..|:...
Worm   480 ---GMLQSIIKGRKESHHSSRSLQSNST---TTTGTTGISSRSVFFPETETQGYFVYMNEPVLAR 538

  Fly   598 KGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDIL 662
            |.||         .|.|.::.:.||::||...|||:..|||...|.|.......||:|||:||::
Worm   539 KYQL---------RVPIFKQDRSELRMLRSIEHDNVNRFIGLSIDGPVYMSFWRYCSRGSIKDVI 594

  Fly   663 ENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIE 727
            ....:.:|..||..::.||..|:.|:|.|||:.||:|.:..|.::.||.||:..:|| :|.||:|
Worm   595 AKSSINMDGFFIYCLIKDIASGLQYIHHSPIKQHGSLTSECCYINDRWQVKIGSYGL-SFMQGVE 658

  Fly   728 DSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEM--H------------ 778
            ..:.|         .||:.|||:||:|   |..|||.||.|||.|:..|:  |
Worm   659 KRTED---------GLLHTAPEVLREG---LTSGTQAGDVYSFSIVCSELVGHSSAWNLENRKEE 711

  Fly   779 -------VRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFD-CVSECLRECWAERPE 835
                   |:||  |.|                   |:||||..::...: .:...:|:||.|.|:
Worm   712 ADEIIFMVKRG--GRT-------------------PFRPSLDDVDDDINPAMLHLIRDCWDEDPK 755

  Fly   836 DRPDFKTIRTKLRPLRKGM--RPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEM 898
            .||:...:...::.:..|.  ..|:.|::.:::||:|::||..|.:|..:|.|||||:|.||:.|
Worm   756 QRPNIDMVNKLMKNMNSGRSGSANLMDHVFSVLEKHASSLEDEVQERMKELVEEKKKSDILLYRM 820

  Fly   899 LPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDV 963
            ||:.||::||.|..|:||.:|.|:|:|||:||||.::.:.||||||:.||||||.||:||...|.
Worm   821 LPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFTVLANKSTPLQVVNLLNDLYTTFDAIIEKNDS 885

  Fly   964 YKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCA 1028
            ||||||||||:||||||.|||..|.|.||.|||.|:.::..|||.|.|..::.:|||:|||...|
Worm   886 YKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFKIPHLPQEKVQIRIGMHSGSCVA 950

  Fly  1029 GVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRL-GGYHFAERGVISMKGKGDQ 1092
            |||||.|||||||||||||||||||:|.|..||.|..|..||..| ..|:...||.:.:||||..
Worm   951 GVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLTSLYKEYNTESRGEVIIKGKGVM 1015

  Fly  1093 RTYWLLGEDEEA 1104
            :||||||..||:
Worm  1016 QTYWLLGMKEES 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	93/415 (22%)
		ANF_receptor	67..416	CDD:279440	87/387 (22%)
		PK_GC-A_B	570..853	CDD:270944	92/310 (30%)
		TyrKc	597..847	CDD:197581	87/271 (32%)
		HNOBA	<862..907	CDD:285003	21/44 (48%)
		CYCc	886..1078	CDD:214485	119/192 (62%)
		Guanylate_cyc	913..1099	CDD:278633	113/186 (61%)
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347	95/422 (23%)
		ANF_receptor	13..368	CDD:279440	87/385 (23%)
		PKc_like	548..770	CDD:304357	82/255 (32%)
		HNOBA	<797..829	CDD:285003	16/31 (52%)
		CYCc	808..1000	CDD:214485	118/191 (62%)
		Guanylate_cyc	835..1022	CDD:278633	113/186 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910