DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-6

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	1179	Identity:	345/1179 - (29%)
Similarity:	568/1179 - (48%)	Gaps:	190/1179 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GNYHSGLLHPLLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTI-------SGA 68
            |.|...::.|||.::..:.    :|. |.||.||:|....     |:.|..|.|.       :.|
Worm     3 GVYLRSVIFPLLFVIQTIC----QPP-GNVFHLGFLHCDV-----LENNVEGSTTYINYRTSASA 57

  Fly    69 ISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQ-QVAAYIGP--QETCVHEGRM 130
            .|:|::::....|. .|:..:|.:.....:|.::......|:.: .|....||  ....:....:
Worm    58 ASIAIDKIKREGLL-LGYDFKFTILYDQCDENIAAGNAIKLFAEHNVDVLFGPTTNNAAMPVFIL 121

  Fly   131 AAAFNLPMISYYCTHRDP-SNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLY---LDDA 191
            |..:|:|:|::..|.... .:::.|||..........::.:...::..:.|.|..|.|   ::|.
Worm   122 ATYYNIPLITWGITSSATLDDESRFPTAGMLSIGSRSLAVTFREVMKEYGWDQFVFAYSLEMNDE 186

  Fly   192 SGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHG---------FMDNPFEALVE-QTYANTRIY 246
            .          ..||.|      |.:  |.:.::|         .||:..|.|:. ....:||..
Worm   187 K----------CETLRD------DFQ--NMVAYYGDIVLSYAVQIMDHSEEGLLAILKDVSTRGR 233

  Fly   247 LILGHYYE------HVGLMVSLQRRGILSKGDYFVV-------GIDIEQYDPAKPEKYLRGLLLE 298
            :|:..::|      |...|:...|.|.:: .:|..:       |..:.|.|......:......:
Worm   234 IIVPCFHEGNSRGLHRRWMLVAARNGFVN-DEYVYIFPSLRSRGYAVPQADGTFRYPWTEATGPQ 297

  Fly   299 DVEPLAVQAFQSYLGIVP-----TASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAA 358
            ..:..|:..||..:.||.     ....::..|.:|:.:.|:.||:|..:....    .:....|.
Worm   298 PGDQEALLGFQKSIFIVDMQGQGNVGSNYTQFEHEIIQRMKEPPYNCTDACAS----PEYQTAAT 358

  Fly   359 Y---LYDAVHLYAKALMEVLDS-GGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVL 419
            |   |:|:|::|...:.:::.: ..:.:||:|....:.|  ..:.:|..|.|||.|
Worm   359 YAGQLHDSVYIYGVVMDQIMKTVPNQYKNGTAFPRKMAG--VFNGVGGTVAIDEGG--------- 412

  Fly   420 ARGSVRNGRNQTVLGLRPVGTFI-----HRNSSL----------SSISKALPHQNLKLFSPIDWV 469
                          ||:|. .|:     :.||||          :.::|...::...|:|...
Worm   413 --------------GLQPT-LFVLTLDSNNNSSLIMTVDVDQQEAVVTKHYTNEATALWSHRK-- 460

  Fly   470 GGTRPAAAPRCGFGGEKC-----VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELD--SLL 527
             |.||...|.||:.|..|     ..|.|...|||......::..:...:|.....:||::  :.|
Worm   461 -GIRPPDQPICGYTGSLCPANVFFQYIGWFIAAIIIIFFTIMGAILAFIYLCHAKQQEVERQNAL 524

  Fly   528 WKIDFREVQ-IHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPD--ADFRYTT 589
            |:|.|:.:. :.:..:.:.|.:                           |:||.|.  :..|.:|
Worm   525 WQIPFKSMMTVTKKGKGEHSMR---------------------------SISSVPSTISSTRSST 562

  Fly   590 IFTPIGLYKGQLY-------AIKKV--RKKSVDITREMK--KELKLLRDARHDNICAFIGACTDP 643
            : :.:|..:..|:       .:::|  :|.|:.:..:.|  ..::.:|...|.|:..|||...|.
Worm   563 L-SEVGETRNYLFFQIQNDVEMERVAAKKHSIRMVFDNKTCATMRQMRLIDHANLNKFIGMSLDA 626

  Fly   644 PNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDS 708
            |.:..:..:|:||||.|::....:::|..||.|::.|||.|:.::|:|...|||.|.:.|||::.
Worm   627 PQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIINGLTWIHESSHEFHGMLTSKNCLLND 691

  Fly   709 RWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGIL 773
            ||.:|:|||||..|:...:.:.:|.          |:.:|||||   :..::|::.||.|||||:
Worm   692 RWQLKITDFGLRIFRTHDQYNKSDR----------LWTSPELLR---TDDILGSREGDIYSFGII 743

  Fly   774 LYEMHVRRGPFG-ETGLTPMQCLQKVLQPQDYLNPYRPSLQPLET--AFDCVSECLRECWAERPE 835
            ..|:..|...|. |......:.:..:|:.....:| ||||:..|:  ....:...:|:||.|||.
Worm   744 SAELITRSSVFDLENRKEDAEEIIYMLKKGGLQSP-RPSLEHDESIEINPALLHLVRDCWTERPS 807

  Fly   836 DRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLP 900
            :|||.|.:.::||.:......|:.|::..::|.||:.||..|.:|..:|.|||||:|.||:.|||
Worm   808 ERPDIKQVASQLRSMNTNRNDNLMDHVFNVLESYASTLEDEVAERMKELVEEKKKSDVLLYRMLP 872

  Fly   901 RCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYK 965
            |.|||:||.|..|:||.::.|:::|||:|.||.::.:|||||||:.||.|||.||.||..:||||
Worm   873 RQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLAGKCTPLQVVNLLNGLYTIFDGIIEQHDVYK 937

  Fly   966 VETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGV 1030
            ||||||.|.|.||:|.|||:.|...||:||::.:.::::|.|.|.|..::.:|:|.|.|.|.|||
Worm   938 VETIGDGYFVASGVPRRNGNEHTRNIASMSINFVKSLADFSIPHLPGEKIKIRVGFHCGSVVAGV 1002

  Fly  1031 VGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTY 1095
            |||.|||||||||.|||||||||:..|.:||.|.:..|:|.||||:....||.:.:||||...||
Worm  1003 VGLTMPRYCLFGDAVNTASRMESNSKPGQIHLSEEANQMLMRLGGFTTEPRGEVIIKGKGVMATY 1067

  Fly  1096 WLLGEDEEA 1104
            |||..||.|
Worm  1068 WLLKMDESA 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	84/445 (19%)
		ANF_receptor	67..416	CDD:279440	73/387 (19%)
		PK_GC-A_B	570..853	CDD:270944	90/298 (30%)
		TyrKc	597..847	CDD:197581	81/263 (31%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	110/191 (58%)
		Guanylate_cyc	913..1099	CDD:278633	102/185 (55%)
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347	88/470 (19%)
		ANF_receptor	57..424	CDD:279440	77/416 (19%)
		PKc_like	585..822	CDD:304357	82/250 (33%)
		HNOBA	<847..879	CDD:285003	18/31 (58%)
		CYCc	858..1048	CDD:214485	109/189 (58%)
		Guanylate_cyc	885..1070	CDD:278633	101/184 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020