Protein Alignment CG10738 and gcy-5

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_496219.1
• Gene: gcy-5 / 191643
• WormBaseID: WBGene00001532
• Length: 1122
• Species: Caenorhabditis elegans
• Alignment Length: 1227
• Identity: 340/1227 - (27%)
• Similarity: 547/1227 - (44%)
• Gaps: 233/1227 - (18%)

  Fly    17 LLHPLLLLLFLLAFSNFR--PTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAG 79
            ||:..::||::|..|..:  |:......:|...|...:.|::.:...|    |.:.:||:
 Worm     3 LLYFSMVLLWVLGASECQVIPSSRRTLRVGIAAAQDTQSGSIGWASCG----GTLPIAVQ----- 58

  Fly    80 RLRDRGHSLQFVVAETYGEEVVSIRQTAA------LWTQQVAAYIGPQ--ETCVHEGRMAAAFNL 136
            .|:.:|....|.| |.|.|.....|.:.|      :....|...:||.  :.....|.::|.:..
 Worm    59 YLKSKGFLTDFDV-EYYMEYTECDRASVAKAGMKFMKEMNVDVVVGPSCGDALAIMGTLSAIYKK 122

  Fly   137 PMISY-YCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAE 200
            .::.: :.:....::...||..|..:|....:..:...:|..|.:.:|:.||..|.....:.|.:
 Worm   123 LVLGWGFVSDTQLADTNRFPYVASVQPTAQTLGLATSRILEMFQFDRVALLYYKDDQDYCKSVMD 187

  Fly   201 TILSTLTDAGVSIRDIR-TWNTIYHHGFMDNPFEALVEQTY----ANTRIYLILG---------- 250
            .:.:||:|.  .:..:| .|.     |.:.:..|||...|.    :..||.|:..
 Worm   188 DVEATLSDP--DLYPVRIVWK-----GELQSDNEALTRSTLQAVKSRARIVLLCAISGPEKRNYL 245

  Fly   251 ----------HYYEHV---------GLMVSLQRR----GILSKGDYFVVGIDIEQYDPAK-PEKY 291
                      :.|.|:         |:..||.::    |:....:.|.|..|..:.:..: .||
 Worm   246 ISIAQQNMTTNEYVHILLTMRSIGYGVQTSLGKKTFANGLTPLWESFTVAPDGNETNARRAAEK- 309

  Fly   292 LRGLLLEDVEPLAVQA-FQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISA 355
               :|:.||......| |..||    |.:::.|         :..||...............:.:
 Worm   310 ---MLVIDVNSDVQDAEFLQYL----TKNIADA---------VRNPPMKCNTSECINASSTSMGS 358

  Fly   356 EAAYLYDAVHLYAKALMEVLDSGGRPRNGS------AIVAAIKGSRYRSAMGYHVY--------- 405
            .|.:|:|..:||..|:.: |:|......|:      .:|.:..|...|..:|.::|
 Worm   359 YARHLFDVFYLYGMAVSK-LNSTDPTVYGNLNLLMPQMVTSFDGMTGRVQIGQNLYRVPTYQLYG 422

  Fly   406 IDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVG 470
            :||      .|..:|..::               ||.  ||| |.:|:....:...::...|
 Worm   423 LDE------KYEQVALVNM---------------TFY--NSS-SQLSRGYSDEGRSVWHFWD--- 460

  Fly   471 GTRPAAAPRCGFGGEKC-VNYTGEISAAIAGGALLLLSLVSLVL------YRNWRYEQELDSLLW 528
            ||||...|.|||.|..| |.:..:....|...:::|:.|:.::|      .|..|.|||..:..|
 Worm   461 GTRPLDTPICGFSGRYCPVQFWDQYGVLIFVASIVLIFLICIMLMCFGFMIRGRRAEQERLNSEW 525

  Fly   529 KIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTP 593
            :|.  .:|:...::|::.....|.|           .:.|...|.:..::.:......||
 Worm   526 QIP--SIQLIMPQKEKRKPNSRRSL-----------QSGPSTITGESKMTIDGGFHENYT----- 572

  Fly   594 IGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSL 658
            :.:::..|  :...:..|:.:.:|.|::...||...|||:..|||...|.|....:.:.|:||||
 Worm   573 VQMFEKDL--VLTTKHHSMQMNKEEKEKFVKLRKLEHDNLNKFIGLSIDGPQFVAVWKMCSRGSL 635

  Fly   659 KDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFK 723
            :||:...:..:|..|:..::.||..|:.:||.|.:..||.|.::.|||:..|.||||||||.|..
 Worm   636 QDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSFLHLHGNLRSATCLVNDSWQVKLTDFGLGALL 700

  Fly   724 QGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF---- 784
            :         :|..:| .:||:.|||:|| |..::.......|.|||.|:..|:..:|..:
 Worm   701 E---------EHTPSK-KRLLWAAPEVLR-GSLTIHQMDPSADVYSFAIIASEILTKREAWDISN 754

  Fly   785 ---------------GETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERP 834
                           |...:.|...|...:.|:                   ::..:::||:|:|
 Worm   755 RKEGADEILYMVKKGGNRTIRPELILDAEVSPR-------------------LTTLVKDCWSEQP 800

  Fly   835 EDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEML 899
            ||||..:.|...|..:......|:.|::..|:|:|.:.||..:::||.:|..||||.|.||..||
 Worm   801 EDRPKAEQICKLLSEMTPRGNTNLMDHVFNMLEEYTSTLEVDIEERTKELTLEKKKADILLSRML 865

  Fly   900 PRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVY 964
            |:.||::||.|..|:||.::.|::.|||:|.||.::|:|:|.|||:.|||||:.||:||..:.||
 Worm   866 PKQVAERLKAGQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTIIEEHGVY 930

  Fly   965 KVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAG 1029
            |||:|||.|:.|||||.:||..|..:|..|||..:.....||:.|.|..::.|||||:|||..||
 Worm   931 KVESIGDGYLCVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGINSGPCVAG 995

  Fly  1030 VVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLL-DRL-GGYHFAERGVISMKGKGDQ 1092
            ||||.|||||||||||||||||||:|.|..||.|.....|| |.. ..|..:.||.:.:||||..
 Worm   996 VVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVIIKGKGVM 1060

  Fly  1093 RTYWLLG---------------------------EDEEARTRRTYERSQRRGSRALN 1122
            .|:|:||                           ||.:.|....|...||.|...::
 Worm  1061 ETFWVLGKTDSDTKSLSTRTTPPITDENWPPQMKEDLKKRAVTPYPERQRSGKSKMD 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	85/463 (18%)
		PK_GC-A_B	570..853	CDD:270944	79/301 (26%)
		HNOBA	<860..907	CDD:462234	21/46 (46%)
		CYCc	886..1078	CDD:214485	107/193 (55%)
gcy-5	NP_496219.1	PBP1_NPR_GC-like	30..439	CDD:380575	87/466 (19%)
		PK_GC	546..816	CDD:270894	82/317 (26%)
		HNOBA	<829..873	CDD:462234	20/43 (47%)
		CYCc	852..1042	CDD:214485	106/189 (56%)