DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-4

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	1173	Identity:	340/1173 - (28%)
Similarity:	533/1173 - (45%)	Gaps:	190/1173 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NYHSGLLHPLLLLLFLLAFSNFRPTHGE----VFTLGYLTASQRRPGNLDYNRPGLTISGAISLA 72
            ||:          :|:.....:..|||:    |..:|...|.:...|::.:...|    ||:.||
Worm     5 NYY----------IFISTILTYNLTHGQGPRPVIRVGITAALKTENGSIGWAYTG----GAVPLA 55

  Fly    73 VEEVNAGRLRDRGHSL----QFVVAETYGEEVVSIRQTAAL---WTQQVAAYIGPQETCVHE--- 127
            ::     .|:..|:.|    :|.|..|..:...::|  |.|   .|......|||  .|...
Worm    56 LQ-----YLKSHGYMLNFDFEFHVEYTECDLANTVR--AGLNFMKTNNYDVIIGP--PCAPALKM 111

  Fly   128 -GRMAAAFNLPMISY-YCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDD 190
             |.::..:..|::.: :.:..:.|:...||..|...|....:......||..:.|.:|:.||..:
Worm   112 MGTLSTIYKKPVLGWGFVSESEISDMNRFPFVASVLPSTKTLGVVTSKLLEIYGWDRVALLYFKN 176

  Fly   191 ASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGH---- 251
            .......|...:..:|.:...|::.:.....   .|.......|.::......|:.|...|
Worm   177 ELDYCSSVVNDVEKSLYNESKSVQIVMKAEI---DGSNSESTSATLQVVKTRARVILFCAHAGGE 238

  Fly   252 --YY------------EHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGL--LLED- 299
              :|            |:|.:|:|::.           ||..::.....|| ..|.||  :.|.
Worm   239 KRFYLIQAGLLGMNSSEYVHVMLSMRS-----------VGFGVQTSVGKKP-LTLSGLPPIWESF 291

  Fly   300 ------VEPLAVQAFQSYLGIVPTASVSFATFANEVNK----YMERPPFNFPNPLGPFGGVKQIS 354
                  :|.||.......:.|..::.|...||...:.|    .:..||.:...|.........:.
Worm   292 TVNPDGMEDLAKSVAAKMIVIDTSSEVRDKTFLQYMTKNIVYAIREPPLSCKVPECLITNATGMG 356

  Fly   355 AEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVL 419
            |.|.:|:|..::|..|:.. |:|......|:..:...|.:.....|...|.::|:         |
Worm   357 AYARHLFDVFYMYGMAVSS-LNSTDPNVYGNLSLLIPKFTTAFEGMTGEVKLNED---------L 411

  Fly   420 ARGSVRNGRNQTVLGLRPVGTFIHRNS-----SLSSISKALPHQNLKLFSPID--------WVGG 471
            ||              :|:......||     ||..||......|: :|:..|        | ||
Worm   412 AR--------------KPLYQVYGLNSEYDQISLIDISLINDTVNV-VFNYADGNTEVWHFW-GG 460

  Fly   472 TRPAAAPRCGFGGEKC-----VNYTGEISAAIAGGALLLLSLVSLV--LYRNWRYEQELDSLLWK 529
            |||...|.|||.|:.|     ..|...:..|||...|:||:::..:  ..||.|.||......|:
Worm   461 TRPPDTPVCGFLGKSCPLPIFEQYRALVIVAIAVTILILLAIIICMSSKIRNRRVEQSRLHSEWQ 525

  Fly   530 IDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNP--DADFR--YTTI 590
            |...::::..:.|..:|.:::              .|.....|...:..|..  .::|:  ||..
Worm   526 IHAIKLRLPMHRRASKSSQES--------------ETESASETENFTSKSGDTMTSEFKETYTIQ 576

  Fly   591 FTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTR 655
            :....|.....:.::::.:      .||.|.:| ||...|:|:..|||...|......:.:.|:|
Worm   577 YLENDLVLTTAHQVQELSQ------AEMMKFVK-LRKLDHENLNKFIGLSIDGSRFVSVWKMCSR 634

  Fly   656 GSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLF 720
            |||:||:......:|..|:..|:.||..|:.|:|.|.:|.||.|.::.|||:..|.|||.||||
Worm   635 GSLQDIISKGSFSMDYFFMFCMIRDIAEGLHYIHKSFLRHHGNLRSATCLVNDSWQVKLADFGL- 698

  Fly   721 AFKQGIEDSSTDMQHMSAKCLK--LLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGP 783
               |.::|.       ..|..|  :|:.|||::| |..|:.......|.|||.|:..|:..:|..
Worm   699 ---QFLQDE-------EEKPFKKNMLWAAPEVIR-GSLSIEQMDSSADIYSFAIVASEILTKREA 752

  Fly   784 FG----ETGLTPMQCLQK-----VLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPD 839
            :.    :.|...::...|     ||:|..:::     ::..:|....|    ::||.|.||:||.
Worm   753 WDLSRRKEGYEEIKYAVKKGGQFVLRPDLHID-----IEVNQTLLALV----KDCWCENPEERPS 808

  Fly   840 FKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVA 904
            .:.:...|..:......|:.|::.:|:|:|.::||..|.:||.:|..||||:|.||..|||:.||
Worm   809 AENVCKVLFDMTPNTEDNLMDHVFSMLEEYTSSLEVEVGERTKELTLEKKKSDILLGRMLPKQVA 873

  Fly   905 DQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETI 969
            ::||.|..|:||.::.|:::|||:|.||.::::|:|.|||:.|||:::.|||||..:||||||:|
Worm   874 ERLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQVVNLLNDVFSNFDSIIEKHDVYKVESI 938

  Fly   970 GDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLK 1034
            ||.::.|||||.|||..|..:|..|||..:.....|:|.|.|..|:.||:||:|||..||||||.
Worm   939 GDGFLCVSGLPNRNGMEHIRQIVGMSLCFMEFCRNFRIPHLPRERVELRVGINSGPCVAGVVGLS 1003

  Fly  1035 MPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFA--ERGVISMKGKGDQRTYWL 1097
            |||||||||||||||||||:|.|..||.|.....||.....|.|.  .||.:.:||||...||||
Worm  1004 MPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLVNNYPYQFETNSRGEVIIKGKGVMETYWL 1068

  Fly  1098 LGE 1100
            ||:
Worm  1069 LGK 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	84/442 (19%)
		ANF_receptor	67..416	CDD:279440	76/391 (19%)
		PK_GC-A_B	570..853	CDD:270944	82/297 (28%)
		TyrKc	597..847	CDD:197581	75/260 (29%)
		HNOBA	<862..907	CDD:285003	21/44 (48%)
		CYCc	886..1078	CDD:214485	105/191 (55%)
		Guanylate_cyc	913..1099	CDD:278633	101/187 (54%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	93/480 (19%)
		ANF_receptor	49..423	CDD:279440	81/425 (19%)
		PKc_like	558..819	CDD:304357	81/288 (28%)
		HNOBA	<834..876	CDD:285003	21/41 (51%)
		CYCc	855..1047	CDD:214485	105/191 (55%)
		Guanylate_cyc	882..1070	CDD:278633	101/187 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920