Protein Alignment CG10738 and gcy-3

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_496037.1
• Gene: gcy-3 / 191641
• WormBaseID: WBGene00001530
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 1246
• Identity: 363/1246 - (29%)
• Similarity: 547/1246 - (43%)
• Gaps: 241/1246 - (19%)

  Fly    17 LLHPLLLLLF-LLAFSNFRPTHGEV---FTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVN 77
            ||.||...|| |::..|...:.|..   ..:|...|.:.:..::.:|..|    ||:.||:|
 Worm     7 LLIPLFFHLFSLVSLQNIPVSTGTTRPKLKVGIAAAQKTQSASIGWNVCG----GAVPLAIE--- 64

  Fly    78 AGRLRDRGHSLQFVVAETYGE----EVVSIRQTAA--LWTQQVAAYIGP--QETCVHEGRMAAAF 134
              ||:..|:...|.. |.|.|    ::.|..:|..  |...:|...|||  .|.......:|..:
 Worm    65 --RLKQAGYVTNFDF-EYYVEYTECDLASTVRTGINFLKNLEVDVIIGPPCSEAIRTMATLATLY 126

  Fly   135 NLPMISY-YCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPV 198
            ..|::.: :.:..|.|:...||......|....:..:...||..:.|.:|:.||..........|
 Worm   127 KKPVLGWGFVSQADLSDMTRFPYLITVLPTSQTLGYAASKLLELYKWDKVALLYYKSEVNHCGGV 191

  Fly   199 AETILSTLTD-----------AGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHY 252
            ...:.:|..|           |.:...|..|.|.:.               :...||..:||  :
 Worm   192 MNDVETTFNDPSTYSIQIVLKAEIDASDNVTTNAVI---------------SSVKTRARIIL--W 239

  Fly   253 YEHVGLMVSLQRRGILSKGDYFV----VGIDIEQY----------------DPAKPEKYLRGL-- 295
            ...:|          ..|.||.:    :|:|.::|                ...|....|.||
 Worm   240 CAQLG----------SEKRDYMIKISQLGLDTDEYVHVLISMRSIGFGVQTFVGKTTFKLSGLTP 294

  Fly   296 -------LLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMER--------PPFNFPNPLG 345
                   :.:.:|.:|.:...:.|.|...:.||...:.:    ||:|        ||.|......
 Worm   295 VWESFSNVTDGLENVAKRGATNVLVIDLNSEVSDKAYLD----YMQRNILNVVKLPPLNCSTVDC 355

  Fly   346 PFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGR---------PR-----NGSAIVAAIKGSRY 396
            .......:.|.|.:|:|.|:||..||..|..:...         |:     ||...:.||..:..
 Worm   356 VSSTATGMGAYARHLFDVVYLYGIALTRVNSTDSAVYDDMSKLIPQFVTSFNGMTGLVAINQNLS 420

  Fly   397 RSAMGYHVY-IDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNL 460
            |..: |.:| :||..:    .|.|...|..:|.....:.|           :.|:.|.|:.|
 Worm   421 RMPL-YQLYGLDEQYE----QTSLMNLSFADGTTVATISL-----------AYSNESSAVWH--- 466

  Fly   461 KLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGE---ISAAIAGGALLLLSLVSLVLY----RNWR 518
                  .| ||.||.|.|.|||.|..|.....|   |...:..|..|::...:|:.:    :|.|
 Worm   467 ------FW-GGIRPLATPICGFLGNSCPLPFWEQYGILIFVGAGVFLIMITTNLICFLFMIKNRR 524

  Fly   519 YEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDA 583
            .||...:..|:|.|  |::.|.||:.:.                         ||:.||.|.|..
 Worm   525 EEQARINSEWQIPF--VKLRELERKSKG-------------------------TSKRSLQSAPST 562

  Fly   584 DFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITR---------EMKKELKLLRDARHDNICAFIGA 639
            ....:.:.|  |....:.|.:|...|..|...:         :|.|.:| ||...|:|:..|||.
 Worm   563 ITGESKVST--GSEFCENYEVKMFEKDMVLTMKFQYMNLNKADMDKFVK-LRKLDHENLNKFIGL 624

  Fly   640 CTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNC 704
            ..|......:::.|:||||.|||...:..:|..|:..::.|:..|:.|||.|.:|.||.|.::.|
 Worm   625 SIDSSQFISVTKLCSRGSLLDILYKGNFSMDFFFMYCIIKDVAEGMSYLHKSFLRLHGNLRSATC 689

  Fly   705 LVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYS 769
            ||:..|.|||.:||   |.|.:|:.:...:       :||:.|||:|| |..::.......|.:|
 Worm   690 LVNDSWQVKLAEFG---FDQLLEEITPTKR-------RLLWAAPEVLR-GSLTVSQMDPSADVFS 743

  Fly   770 FGILLYEMHVRRGPFG----ETGLTPMQCLQKVLQPQDYLNPYRPSL-------QPLETAFDCVS 823
            |.|:..|:..|:..:.    :.|..  :.:.:|.:...:  |.||.:       .|...|.
 Worm   744 FAIIASEILTRKEAWDLKERKEGYD--EIIYRVKKGGSF--PIRPDIITDVPDVNPTLIAL---- 800

  Fly   824 ECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEK 888
              :::||||.|||||..:.|..:||.|....:.|:.|::..|:|:|.:.||..|::||.:|..||
 Worm   801 --VKDCWAEAPEDRPTAENICEQLRDLMPKTKSNLMDHVFNMLEEYTSTLEVEVEERTKELTLEK 863

  Fly   889 KKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTC 953
            ||.|.||..|||:.||::||.|..|:||.::.|:::|||:|.||.::::|||.|||:.|||||:.
 Worm   864 KKADLLLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCTPFQVVNLLNDLYSN 928

  Fly   954 FDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLR 1018
            ||:||..:.|||||:|||.|:.|||||.|||..|..:|..|||..:.....|||.|.|..|:.||
 Worm   929 FDTIIEEHGVYKVESIGDGYLCVSGLPTRNGFNHIKQIVDMSLKFMDYCKNFKIPHLPRERVELR 993

  Fly  1019 IGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFA---- 1079
            ||::|||..||||||.|||||||||||||||||||:|.|..||.:.....||.:    ||.
 Worm   994 IGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTSDAHLLLMK----HFPHQYE 1054

  Fly  1080 --ERGVISMKGKGDQRTYWLLGE----DEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANE 1138
              .||.:.:||||...|:|:||.    :.....|.|...:|.|.:      ::..........:.
 Worm  1055 TNSRGEVIIKGKGVMETFWVLGRSGDIEPSISNRSTPPVTQERFT------VRAPDTPEARSVSS 1113

  Fly  1139 YGIRSSLKQKN 1149
            :|.|.|....|
 Worm  1114 HGSRPSSNHNN 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	96/471 (20%)
		PK_GC-A_B	570..853	CDD:270944	89/302 (29%)
		HNOBA	<860..907	CDD:462234	22/46 (48%)
		CYCc	886..1078	CDD:214485	106/191 (55%)
gcy-3	NP_496037.1	PBP1_NPR_GC-like	36..452	CDD:380575	95/461 (21%)
		Protein Kinases, catalytic domain	554..823	CDD:473864	84/292 (29%)
		HNOBA	<838..882	CDD:462234	21/43 (49%)
		CYCc	861..1051	CDD:214485	108/193 (56%)