DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	1250	Identity:	341/1250 - (27%)
Similarity:	542/1250 - (43%)	Gaps:	258/1250 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLLFLLAFSNF---------RPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVN 77
            :||||.:..|.|         .|.......:|...|.:.:..::.::..|    ||:.||:|
Worm     6 ILLLFNIFPSIFVQNLPDTTVAPRTKRTIKIGIAAAQRIQTSSIGWSVCG----GAVPLAIE--- 63

  Fly    78 AGRLRDRG----HSLQFVVAET---------YGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGR 129
              ||::.|    ...:::|..|         .|.|.:.        |.:|...|||  .|....|
Worm    64 --RLKEMGFVKDFDFEYIVDYTECDLGSVVRAGMEFIK--------THKVDVIIGP--PCAQALR 116

  Fly   130 ----MAAAFNLPMISY-YCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLY-- 187
                :|..:..|::.: :.:..|.|:...||......|....:..:...:|..|:|.:|:.||
Worm   117 LMSFLAENYKKPVLGWGFVSDTDLSDVIRFPHLTTVIPNSLMLGYAASKMLTTFHWNRVALLYYF 181

  Fly   188 ---------LDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEAL-------- 235
                     ::|....:...:...::.:..|.:.:.|..|         .||.|:.:
Worm   182 SDVKYCSGVMNDIEATFNDPSTPNVNIVIKAEIYLNDNET---------TDNVFQTVKSRARIIL 237

  Fly   236 -VEQTYANTRIYLI-------LGHYYEHV---------GLMVSL-----QRRGILSKGDYFVVGI 278
             ..||....|.|||       :|..|.|:         |...||     .:.|:....:.|..|.
Worm   238 WCTQTSVEKRDYLIKIATHDMIGDEYVHIMLSMRNVAFGTQTSLGKPTFSQSGLTPIWESFTEGT 302

  Fly   279 DIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNP 343
            |  .::....:...|..:|:....:|.:.:..|:             ...:.|.::.||.|....
Worm   303 D--GFEKMAKQAATRMFVLDVNSEVADKKYLEYM-------------QKNIIKAVQSPPMNCSTV 352

  Fly   344 LGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDE 408
            .........:...|.:|:|.|:||..||... :|......|...|...:.......|..||.|..
Worm   353 ECMTANTTIMGGYARHLFDVVYLYGIALTHT-NSTDPAVYGDVDVLVHQFVTSFQGMTGHVVISP 416

  Fly   409 NGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSI---------SKALPHQNLKLF- 463
            |                       |...|:......||....:         |..:|  |:.||
Worm   417 N-----------------------LTRMPIFQLYGLNSDYDQVALVDFTYTNSVMVP--NVTLFY 456

  Fly   464 -----SPIDWVGGTRPAAAPRCGFGGEKC-----VNYTGEISAAIAGGALLLLSLV--SLVLYRN 516
                 :...:.|.:||...|.|||.|:.|     ..|...|..|||...|::|.::  .|.:...
Worm   457 KDEGGAVWSYYGHSRPLDIPICGFLGKSCPVSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISG 521

  Fly   517 WRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNP 581
            .|.|:...:..|::.|  .::.|:|::.:.:..:|..|         ||. |.|.|....:::..
Worm   522 KRAERARINAEWQVPF--AKLIESEKQVRGKGASRRSL---------QSA-PSISTGHSGVTTVS 574

  Fly   582 DADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNI 646
            |....||.:     :|:.::  :...:.:...:|:..|:....:|...|:||..|||...|..:.
Worm   575 DFCENYTMM-----MYEKEM--VLTAKYQYTHLTKADKERFVKMRKLDHENINRFIGLSIDSAHF 632

  Fly   647 CIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWV 711
            ..:::.|:||||:|||...:..:|..|:..::.|:.:|:.|||.:.:|.||.|.::.|||:..|.
Worm   633 ISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQ 697

  Fly   712 VKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYE 776
            |||.::|:        |:..:.|....|  :||:.|||:|| |..|:.......|.|||.|:..|
Worm   698 VKLAEYGM--------DNLVEEQTPPKK--RLLWVAPEVLR-GSLSVSQMEPSADIYSFAIIASE 751

  Fly   777 M---------------------HVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFD 820
            :                     :|::|     ||.|::  .:::.....:||...:|
Worm   752 ILTKKEAWDILDRKEDCEEIVYNVKKG-----GLFPIR--PEIITDIHDVNPALIAL-------- 801

  Fly   821 CVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQ 885
                 :::||||.|||||..:.|.::::.|....:.|:.|::..|:|:|.:.||..:::||.:|.
Worm   802 -----VKDCWAEVPEDRPTAENICSQMKGLVSKQKTNLMDHVFNMLEEYTSTLEEEIEERTKELT 861

  Fly   886 EEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDL 950
            .||||.|.||..|||:.||::||.|..|:||.::.|:::|||:|.||.::::|:|.|.|:.||||
Worm   862 LEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDL 926

  Fly   951 YTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRL 1015
            |:.||:||..:.|||||:|||.|:.|||||.|||..|..:|..|||..:.....|.|.|.|...:
Worm   927 YSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENV 991

  Fly  1016 LLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDR--LGGYHF 1078
            .||||::|||..||||||.|||||||||||||||||||:|.|..||.:.....||..  ...|..
Worm   992 ELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYET 1056

  Fly  1079 AERGVISMKGKGDQRTYWL---LGEDEEARTRRTYER--------------SQRRGSRALN---- 1122
            :.||.:.:||||...|:|:   .||.|....|....|              |...|||..:
Worm  1057 SSRGEVIIKGKGVMETFWVHGRFGEMEPTELRSISNRSTPPVTNDRWIPNPSSSHGSRPSSVYDP 1121

  Fly  1123 -----KFIQGTIKQA 1132
                 ||...|:|.|
Worm  1122 LQGHQKFKMDTLKVA 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	84/458 (18%)
		ANF_receptor	67..416	CDD:279440	79/407 (19%)
		PK_GC-A_B	570..853	CDD:270944	80/303 (26%)
		TyrKc	597..847	CDD:197581	74/270 (27%)
		HNOBA	<862..907	CDD:285003	20/44 (45%)
		CYCc	886..1078	CDD:214485	103/193 (53%)
		Guanylate_cyc	913..1099	CDD:278633	96/190 (51%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347	87/480 (18%)
		ANF_receptor	53..432	CDD:279440	83/445 (19%)
		PKc_like	555..821	CDD:304357	83/313 (27%)
		HNOBA	<840..883	CDD:285003	20/42 (48%)
		CYCc	862..1051	CDD:214485	102/188 (54%)
		Guanylate_cyc	889..1077	CDD:278633	96/187 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910