DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and phlp-2

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	1097	Identity:	187/1097 - (17%)
Similarity:	343/1097 - (31%)	Gaps:	367/1097 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LLEDVEPLAVQAFQSYLGIVPTASVSFATFA-----NEVNKYMERPPFNFPNPLGPFGGVKQISA 355
            |..|..|||:  .|.:..|:..:..:..|.:     .::..|.:.|.|.
Worm    72 LKSDTSPLAI--LQDFCRILTMSDENLETESTSKALEDILSYTDSPAFR---------------- 118

  Fly   356 EAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLA 420
                     |:::..|       ||||           .|.:|.:...:..:|        .|:.
Worm   119 ---------HIFSFFL-------GRPR-----------IRAKSTLNLDILSEE--------VVIR 148

  Fly   421 RGSV----RNGRNQTVLGLRPVGTFIHRNSSL---SSISKALPHQNLKLFSPIDWVGGTRPAAAP 478
            :|.:    :|.|          ..|.:.|..|   ::..:||..:|:|:
Worm   149 KGKLIHTWQNAR----------AVFYNSNIRLQTKNNQDEALQIRNMKV---------------- 187

  Fly   479 RCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHEN--E 541
                          ::..:..|.||.|..                |.:.:.|.|:...|.|.  .
Worm   188 --------------DVHESKRGRALRLKD----------------DDVCYLIIFQRPNILEAWLT 222

  Fly   542 REQQSQKQTRHL------LNHLPRR-LPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKG 599
            |.||.:| :.|:      |..:|.: |..::...::...:.||.|.|..:    ....|:| |..
Worm   223 RAQQVEK-SNHVDASDEQLTLIPEQILNNEARVQILNLRRNSLISRPPTE----KSMAPLG-YID 281

  Fly   600 QLYAIKKVRKKSVDITR----EMKKELKLLRDARHDNICA-FIGACTDPPNICIISEYCTRGSLK 659
            .||.:..:  :.:|::.    ....:|.||...|..|:.: :|.:         :...|:.....
Worm   282 DLYRVHSL--QVIDLSANQILSFPIQLTLLSHLRQLNLSSNYISS---------VPSECSNMRRL 335

  Fly   660 DILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVD---SRW------VVKLT 715
            ..|...:.:||.:      .|.|..:..|....|.|:.......||..   ..|      :.|:.
Worm   336 QYLNLSNNQLDTL------PDSISELQNLQSLDISFNQFSQIPPCLFHLTLEMWRLAGNNIEKID 394

  Fly   716 DFG-----LFAFKQGIEDSS-----TDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSF 770
            ..|     ....::.:.|:|     .::.|:..:...::           |::.:...|
Worm   395 RVGEMQIQKIDLRRNVLDTSFRLDIENITHLDLRDNSMI-----------STVHLTNLR------ 442

  Fly   771 GILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLN-----PYRPSLQPLETAF-------DCVS 823
              .|..:|..|.......|:. :.|..|....:.|:     |...:||.|..:|       |.:|
Worm   443 --FLKVIHCERLQLSSLHLSG-ESLTHVYADHNLLDSLVVMPLPQNLQTLSLSFNHFRNLPDWIS 504

  Fly   824 ECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEE- 887
            :|            |:...:|.....|........:...:..:..:.|.:|.:.|...:...|.
Worm   505 DC------------PNLTFLRANNNSLVALPERIFYSQSLRSIFAFINEIEHIPDFGEENCLETL 557

  Fly   888 ---KKKTDAL---LHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAEC-------- 938
               |.|..:|   ...:|||  ..||            .:|..|.:::.:...|:.|
Worm   558 ILYKNKLSSLPKHFFSILPR--LRQL------------NISSNFIELLPYFDGSSFCRLQILRCA 608

  Fly   939 --------TP-------LQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGD--- 985
                    .|       |:::|..::....||...    :..:|.:.|..:..:.| .|..|
Worm   609 NNYLTENSVPVIVNMKHLKIIDLSHNRLNSFDDSA----LSSLELLEDLNLSSNRL-TRLADCLA 668

  Fly   986 -LHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTAS 1049
             |...::.....:.|..|.||    |.:|: |..|.:.|..:..|.:..|.|......|....:.
Worm   669 LLPCLQVLRAHSNQLVHVPEF----RASNQ-LHTIDVSSNNISLGTLQFKAPPNLRHFDVTCNSG 728

  Fly  1050 RMESSGVP--LKIHCSWQCRQLLD---RLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRT 1109
            ..::...|  .|:|.......:.:   .|.|:.....|...||.|...|         :.|...|
Worm   729 DFDTENFPENAKMHSKMNTINISEGSQNLFGFQIGVSGSRGMKNKQCIR---------QVRVENT 784

  Fly  1110 Y----ERSQRRGSRALNKFIQGTIK----------------QAQEQANEYG-----IRSSLKQKN 1149
            :    ..|....|.::.:|:...:|                :..|:....|     ||...|:..
Worm   785 FGFIDGGSNSYMSSSICRFMTSYLKENVSMDIRSILLRCHCELGEEGERLGASVMIIRVHEKRLE 849

  Fly  1150 LPRNSLTRSSSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSG------------GS 1202
            :.... |.|:::...:||:     ::.:.||..|:     |.|:.:|.:.|            ||
Worm   850 IASTG-TMSAAIARNQKLK-----MIINGRYEIDD-----DEYSRIREAHGFVDEENRINGVIGS 903

  Fly  1203 TQSRYEETTLSLTLSCQS---------IE--IVGGQ---------------HNKRRP 1233
            ::.....:|..:.|...|         ||  |||..               ||.|.|
Worm   904 SRQIGHFSTFPVVLPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNNRSP 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	24/153 (16%)
		ANF_receptor	67..416	CDD:279440	20/124 (16%)
		PK_GC-A_B	570..853	CDD:270944	53/318 (17%)
		TyrKc	597..847	CDD:197581	46/285 (16%)
		HNOBA	<862..907	CDD:285003	10/51 (20%)
		CYCc	886..1078	CDD:214485	42/230 (18%)
		Guanylate_cyc	913..1099	CDD:278633	38/217 (18%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	4/20 (20%)
		leucine-rich repeat	254..288	CDD:275380	9/38 (24%)
		PLN00113	283..>718	CDD:331614	85/507 (17%)
		leucine-rich repeat	289..311	CDD:275380	4/23 (17%)
		leucine-rich repeat	312..334	CDD:275380	4/30 (13%)
		leucine-rich repeat	335..357	CDD:275380	5/27 (19%)
		leucine-rich repeat	358..379	CDD:275380	5/20 (25%)
		leucine-rich repeat	380..440	CDD:275380	7/70 (10%)
		leucine-rich repeat	441..485	CDD:275380	9/52 (17%)
		leucine-rich repeat	486..508	CDD:275380	7/33 (21%)
		leucine-rich repeat	509..534	CDD:275380	2/24 (8%)
		leucine-rich repeat	554..577	CDD:275380	5/22 (23%)
		leucine-rich repeat	578..602	CDD:275380	6/35 (17%)
		leucine-rich repeat	603..625	CDD:275380	1/21 (5%)
		leucine-rich repeat	626..649	CDD:275380	4/26 (15%)
		leucine-rich repeat	650..672	CDD:275380	5/22 (23%)
		leucine-rich repeat	673..694	CDD:275380	5/24 (21%)
		PP2Cc	754..985	CDD:214625	43/227 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900