DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10738 and gcy-20

DIOPT Version :9

Sequence 1:NP_729905.2 Gene:CG10738 / 39516 FlyBaseID:FBgn0036368 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_507101.1 Gene:gcy-20 / 184797 WormBaseID:WBGene00001545 Length:1108 Species:Caenorhabditis elegans


Alignment Length:1255 Identity:384/1255 - (30%)
Similarity:559/1255 - (44%) Gaps:274/1255 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LLLLLFLLAFSNFRPT--HGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRD 83
            ||||..:|.|..|..|  .|.:|:..  |||..|  ::.|.    |.:.|:.:|.:.:.|..|.|
 Worm     5 LLLLQNILVFCQFLQTIKVGLMFSKD--TASVIR--SVGYR----TSAAAVLVAKDRIRAEHLLD 61

  Fly    84 RGHSLQFVVA-ETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEG----RMAAAFNLPMISYYC 143
            : :...|.:. :...|.:.:.:....|....|...|||  ||...|    .:|..:|:|:..:..
 Worm    62 Q-YDFNFTIKFDECSESLAAGKVVELLTHDNVDVIIGP--TCNRAGVAVASLADFYNVPVFQWGL 123

  Fly   144 THRDPSNKADFPTFAR-----TRPPDT-QISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETI 202
            |     ..||...|:|     |...|| .||.:|..:|..:.|::..|:|.:|  |..:..| .:
 Worm   124 T-----TTADIGNFSRYQTTVTLSLDTHSISLAVREILRQYGWSEFVFIYSND--GDEEKCA-AM 180

  Fly   203 LSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQR--- 264
            ...:...|:...|:                          |..|:|    ......|.||||   
 Worm   181 KDDMEKMGIENSDV--------------------------TMAYMI----QIQTVTMESLQRTLL 215

  Fly   265 ----RG-----ILSKGDYF---------VVGIDIEQYDPAKPEKYLRGLLLEDVEPLA------- 304
                ||     ..:.|..|         :.|:..|:|.....|...||..:::.:...       
 Worm   216 EVSKRGRIIIACFASGRGFKKAFIASTVLAGMSTEEYLYVFAEPQSRGFYVDEADGKVHYSWDDT 280

  Fly   305 ----------VQAFQSY---------LGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGV 350
                      .|...:|         :|...|.:..:..|.::|...|...|||....... ...
 Worm   281 DGQLVTGLTNEQIRDAYGKVLYICDNMGEPTTITTQYTNFTSQVISRMAEQPFNCVQDCSN-QSY 344

  Fly   351 KQISAEAAYLYDAVHLYAKALMEVL---DSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDA 412
            |..:..|..|.|:.:.||.||.:.|   .:....:|||.:::.| |..::...|..|.:||:|..
 Worm   345 KHAATYAGQLADSFYAYAFALNKSLTQDPTRSNLKNGSFVLSNI-GMTFQGVGGEAVTLDESGSR 408

  Fly   413 AGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKL--------FSPID-- 467
            .....:.|                       .||||      ||:....|        |:|..  
 Worm   409 IVQVYMFA-----------------------MNSSL------LPYMAASLLVNVSEVVFTPFYKS 444

  Fly   468 ----WVGGTRPAAAPRCGFGGEKC-VNYTGE------------ISAAIAGGALLLLSLVSLVLYR 515
                |  ..||.:.|:|||.|.:| .::..|            |.|.:||.|.||.::      .
 Worm   445 ESELW--SVRPLSRPKCGFTGLECPADFVKEYLVYTIIAAFIVILALLAGCAGLLYTM------H 501

  Fly   516 NWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSN 580
            ..|.|.|...|||::.|.|:        ||.|.::|                  ...|..|.:|.
 Worm   502 MKRKEMERQDLLWQVAFVEL--------QQVQSKSR------------------AEASMHSFASG 540

  Fly   581 PDADFRYTT---------IFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAF 636
            |....:.|.         ||..   |..::.|.|| ....|......|.|.:.:|:..:||:..|
 Worm   541 PSTSTKMTVESRTETTNFIFYH---YHQEVVAAKK-HDLLVLFDANQKSEFRQMRNFDNDNLNKF 601

  Fly   637 IGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCT 701
            ||.|.|.|.:..:..:|:||||.|::....:::|:.|:.|::.||..|:.::|.|.::.||.|.:
 Worm   602 IGLCLDGPQLLSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLYFIHSSFLKCHGQLTS 666

  Fly   702 SNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGD 766
            ..||:|.||.:|::.|||.:.:........|          ||:.:||.||......:   ..||
 Worm   667 RCCLIDDRWQIKISGFGLKSVRTFENPKKED----------LLWASPEYLRNEDQERL---PEGD 718

  Fly   767 AYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYL---------NPYRPSLQPLETAF--D 820
            .|||||:..|:..|...|.         |:...:..|.:         ||.||||...||..  .
 Worm   719 IYSFGIICAEILTRSSAFD---------LENRKEKPDVIIYQVKKGGHNPTRPSLDTGETVVINP 774

  Fly   821 CVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQ 885
            .:...:|:||.|||.:||..:.:|:.|..::.|.:.|:.|::..|:|.||:.||..|.|||.:|.
 Worm   775 ALLHLVRDCWTERPSERPSIEQVRSHLNGMKDGRKTNLMDHVFNMLETYASTLEEEVSDRTKELT 839

  Fly   886 EEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDL 950
            |||||:|.||:.||||.|||:||.|..|:||.:|||:|:|||:|.||.::.:|||||||..||||
 Worm   840 EEKKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDL 904

  Fly   951 YTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRL 1015
            ||.||.||...||||||||||.|:.|||||.|||:.|...||.|||..||::..|:::|.|..|:
 Worm   905 YTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSLEFFRVQHLPAERI 969

  Fly  1016 LLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDR-LGGYHFA 1079
            .|||||:.|.|.||||||.|||||||||.|||||||||:|.|.:||.:.:..::|.: :||:...
 Worm   970 NLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRMLTQVVGGFRTE 1034

  Fly  1080 ERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIR-- 1142
            .||.:.:||||...|:|||||          |......|:|..|.||          :...||  
 Worm  1035 SRGEVIIKGKGVMETFWLLGE----------ESGYTAPSKAAPKVIQ----------HRQSIRSI 1079

  Fly  1143 SSLKQKNLPRNSLTRSSSLE 1162
            |.:.:|| ...|.|.|.|::
 Worm  1080 SPILEKN-AEGSETSSLSVD 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10738NP_729905.2 PBP1_Speract_GC_like 41..441 CDD:107365 93/460 (20%)
ANF_receptor 67..416 CDD:279440 85/409 (21%)
PK_GC-A_B 570..853 CDD:270944 86/302 (28%)
TyrKc 597..847 CDD:197581 78/260 (30%)
HNOBA <862..907 CDD:285003 26/44 (59%)
CYCc 886..1078 CDD:214485 117/192 (61%)
Guanylate_cyc 913..1099 CDD:278633 108/186 (58%)
gcy-20NP_507101.1 PBP1_NPR_GC_like 22..439 CDD:107347 101/496 (20%)
ANF_receptor 44..418 CDD:279440 86/439 (20%)
PKc_like 536..801 CDD:304357 84/290 (29%)
STYKc 562..801 CDD:214568 78/264 (30%)
HNOBA <818..861 CDD:285003 26/42 (62%)
CYCc 840..1032 CDD:214485 117/191 (61%)
Guanylate_cyc 867..1054 CDD:278633 108/186 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 238 1.000 Domainoid score I1279
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D123766at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11920
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.920

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