Protein Alignment CG10738 and gcy-11

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001359843.1
• Gene: gcy-11 / 181745
• WormBaseID: WBGene00001537
• Length: 1168
• Species: Caenorhabditis elegans
• Alignment Length: 1157
• Identity: 350/1157 - (30%)
• Similarity: 566/1157 - (48%)
• Gaps: 161/1157 - (13%)

  Fly    64 TISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEG 128
            |:.|..|:..::.|.     ....|..::|:|...:             .:...:|.:..|....
 Worm    78 TVQGNFSIGRQDGNY-----MSSMLDIMLADTKKND-------------GLLGVVGVENDCKEIA 124

  Fly   129 RMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISK--SVVALLLAFNWTQVSFL-YLDD 190
            .:|.|::...:...|  .|...::..|:....:...||..|  :...|..:..|..::.: :::|
 Worm   125 ALAQAYDASSLLVNC--EDQVGESQMPSSTALQMSSTQGGKYRAFAKLAKSVGWNNLAVINFVED 187

  Fly   191 --ASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGF-------MDNPFEALVE---QTYANT 243
              |...|.   :.:|..|:...:|:      :.:...||       |....|::::   :||..|
 Worm   188 GPADISYH---DQLLDALSAESISL------DFVKKGGFSSTITSAMFTGLESVIDVILETYMKT 243

  Fly   244 RIYLIL------GHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPA--------------KP 288
            |||:|:      |.::     |.::...|:|..|.||||.:...:.|.|              |.
 Worm   244 RIYVIVLDLPVSGTFF-----MNAMSTMGLLETGKYFVVMMSSIESDAANYFGFNVNRGNMIFKT 303

  Fly   289 EKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMER----------PPFNFPNP 343
            ..|  |:...|:.    |.::|::........: ..|::|...:.:|          ||......
 Worm   304 IDY--GISDADIR----QYYRSFMYFTDVPHYT-KDFSDEWTSFQKRVDGDASKTFCPPMCNTKA 361

  Fly   344 LG-----PFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRP--RNGSAIVAAIKGSRYRSAMG 401
            .|     |:.......:|:..:.||..| .:.|.|.:...|..  |:..::|..:.|....|.:|
 Worm   362 KGIANNDPWSDDAYWYSESPSIVDAYDL-GRLLSETVKVHGASLLRDPESLVQTMSGRGVTSLLG 425

  Fly   402 YHVYIDENGDAAGNYTVLA--RGSVRNG----RNQTVLGLR--PVGTFIHRNSSLSSISKALPHQ 458
            |....:.||.:...|.:.|  :.|..||    .....|..|  |.|     ..:.|.|.|.|  .
 Worm   426 YVTKFNTNGVSQREYILWAPQQASSSNGPIPLPEWATLAARMLPDG-----KGNYSIIWKNL--T 483

  Fly   459 NLKLFSPIDWVGGTRPAAAPRCGFGGEKC---VNYTGEIS-AAIAGGALLLLSLVSLVLY-RNW- 517
            .|.:|:      |..|.:.|.|||..|.|   :....|:. ..||...:.:|.||.::.| ..|
 Worm   484 QLGIFN------GELPQSKPECGFNNELCPAGIRNLSELEIIVIAVCVVAILILVGVIAYIARWI 542

  Fly   518 RYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPL------------- 569
            .||:.|:|..:.:..:.||:.:..:...|:..:. :.:.:..|...:.:.|:
 Worm   543 AYERRLESSYFLVHRKHVQLVDMTKFGSSRGGSM-IQSAMSMRSQYEDSGPVGGATMNFYTNGIR 606

  Fly   570 ---IRTSQVSLSSNPDA---DFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDA 628
               ||.:|:..|....|   |.....:...:..|:..|..::|:.|..:.:|||||:|:.||.:.
 Worm   607 KAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAKYENTLVTVRKINKTQLKLTREMKQEIDLLMNE 671

  Fly   629 RHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHD-SP 692
            .|:|:..|.|...:...|..|..|..|.||.|:|.|:|::||.||..|.|.|:::|:.:||: |.
 Worm   672 THENLNRFFGLINESDLIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSK 736

  Fly   693 IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQ---- 753
            |.:||.|.:|||:||:.|.:||:::|:...:....:|..|         .||:.|||::|:
 Worm   737 IGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPD---------DLLWFAPEIIRRYAVK 792

  Fly   754 -GPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLET 817
             ..|.|.:.  :.|.||..|:|||::.|:||||:..|...:.::::..| |.....||.:..:..
 Worm   793 HDLSKLELA--KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFP-DGGALTRPDIHLITK 854

  Fly   818 AFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTD 882
            |...::..:.:||.|.|..||..|.:|..|:||.||::.||.||:|.::::|.||||.::.:||:
 Worm   855 APYPLASVVEKCWVEDPASRPSIKKVRELLKPLSKGLKGNIADNIMNLLDRYRNNLEDVIKERTE 919

  Fly   883 QLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFL 947
            ||::|:|:.::||.::||:.||:.||.|..||.|.|:.|||||||||||||:|::.||||||:.|
 Worm   920 QLEDERKRNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNML 984

  Fly   948 NDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPT 1012
            |:|||.||:||..:|.|||||||||||.|||||..|..|||.|:|:.||.||.::..|.:.|.|.
 Worm   985 NNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTFTVSHCPD 1049

  Fly  1013 NRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYH 1077
            .:|.||||.|:|||..||||::|||||||||||..|:.|||||.|::|..|....:|:.:.|||.
 Worm  1050 EKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDAYELILKCGGYV 1114

  Fly  1078 FAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQR--RGSRALNKFIQG 1127
            ..:|..|.:|.|.:..|||:....::||..|.....::  .....::||.:|
 Worm  1115 TEQREKIVLKNKLEVMTYWMNDYSKDARLARLVAHQEKFPHLEHLIHKFNKG 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	84/436 (19%)
		PK_GC-A_B	570..853	CDD:270944	95/291 (33%)
		HNOBA	<860..907	CDD:462234	20/46 (43%)
		CYCc	886..1078	CDD:214485	111/191 (58%)
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:471960	49/230 (21%)
		Protein Kinases, catalytic domain	640..890	CDD:473864	89/261 (34%)
		CYCc	923..1116	CDD:214485	111/192 (58%)