DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Npr1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_032753.5	Gene:	Npr1 / 18160	MGIID:	97371	Length:	1057	Species:	Mus musculus

Alignment Length:	1146	Identity:	415/1146 - (36%)
Similarity:	594/1146 - (51%)	Gaps:	173/1146 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLHPLLLLLFLLAFSNFRPTHGEVFTLGY---LTASQRRPGNLDYNRPGLTISGAISLAVEEVNA 78
            ||.|||||         |..|....|:..   ||       |..|......:..|:.||:
Mouse    16 LLPPLLLL---------RSGHASDLTVAVVLPLT-------NTSYPWSWARVGPAVELAL----- 59

  Fly    79 GRLRDR-----GHSLQFVVAETYGEEVVSIRQTAAL------WTQQVAAYIGPQETCVHE----G 128
            ||::.|     |.:::.|:..:.....|.....|.|      |....|.::||  .||:.    |
Mouse    60 GRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGP--GCVYSAAPVG 122

  Fly   129 RMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASG 193
            |..|.:.:|:::..........|.::....||.|...::...|.||.....|...:.:...|..|
Mouse   123 RFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLG 187

  Fly   194 QYQP---VAETILSTLTDAGVSIRDIRTWN-TIYHHGFMD---NPFEALVEQTYANTRIYLILGH 251
            ..:|   :.|         |:.:|.....| |:.|..|::   :.:..|:.......|:..|...
Mouse   188 DDRPCFFIVE---------GLYMRVRERLNITVNHQEFVEGDPDHYTKLLRTVQRKGRVIYICSS 243

  Fly   252 YYEHVGLMVSLQRRGILSKGDYFVVGIDI--------EQYDPAKPEKYLRGLLLEDVEPLAVQAF 308
            ......||:.....|:..: ||....:|:        :...|.||.:...|     .:..|.|||
Mouse   244 PDAFRNLMLLALDAGLTGE-DYVFFHLDVFGQSLQGAQGPVPRKPWERDDG-----QDRRARQAF 302

  Fly   309 QSYLGIVPTASVSFATFANEVN-KYME---------RPPFNFPNPLGPFGGVKQISAEAAYLYDA 363
            |         :....|:....| :|:|         ...|||...    .|:|.|.  .|..:|.
Mouse   303 Q---------AAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTME----DGLKNII--PASFHDG 352

  Fly   364 VHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVL----ARGSV 424
            :.||.:|:.|.|..||...:|..|...:....::...|| :.||.|||...::::.    ..|:.
Mouse   353 LLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGY-LKIDRNGDRDTDFSLWDMDPETGAF 416

  Fly   425 R-----NGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGG 484
            |     ||.:|.::.:..     ||                     :.|..|..|...|:|||..
Mouse   417 RVVLNFNGTSQELMAVSE-----HR---------------------LYWPLGYPPPDIPKCGFDN 455

  Fly   485 E--KCVN---YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQ 544
            |  .|..   .|.|:.|.:...:|:...:||..:||..:.|:||.|.||::.:.::|....||..
Mouse   456 EDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHL 520

  Fly   545 QSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRK 609
            :|......|..               |.|........:..|:   :|.....|||.|.|:|:|.:
Mouse   521 RSAGSRLTLSG---------------RGSNYGSLLTTEGQFQ---VFAKTAYYKGNLVAVKRVNR 567

  Fly   610 KSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFI 674
            |.:::||::..|||.:||.:::::..|:|||||||||||::|||.||||:||||||.:.||.||.
Mouse   568 KRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFR 632

  Fly   675 ASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAK 739
            .|:..||::|:::||:..|..||.|.:|||:||.|:|:|:||:||.:|:    |...:..|  ..
Mouse   633 YSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFR----DPEPEQGH--TL 691

  Fly   740 CLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETG--LTPMQCLQKVL--- 799
            ..|.|:.||||||.. |....|:|.||.|||||:|.|:.:|.|.|...|  |:|.:.:::|.
Mouse   692 FAKKLWTAPELLRMA-SPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGE 755

  Fly   800 QPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMA 864
            ||     |:|||:. |::..:.:.:.::.||||.|::||.|:.||..||...|....||.||:::
Mouse   756 QP-----PFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLS 814

  Fly   865 MMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIV 929
            .||:||||||.||::||....|||:|.:|||:::||..||:|||:|..|..|.::.|:|||||||
Mouse   815 RMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIV 879

  Fly   930 GFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATM 994
            ||||:|||.||:|||..|||||||||::|.::|||||||||||||||||||:|||.|||.|:|.|
Mouse   880 GFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARM 944

  Fly   995 SLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLK 1059
            :|.||.||..|:|||||..:|.||||||:||||||||||||||||||||||||||||||:|..|:
Mouse   945 ALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALR 1009

  Fly  1060 IHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGE 1100
            ||.|.:.:.:|:...|:....||.:.|||||..||||||||
Mouse  1010 IHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	95/451 (21%)
		ANF_receptor	67..416	CDD:279440	85/388 (22%)
		PK_GC-A_B	570..853	CDD:270944	119/287 (41%)
		TyrKc	597..847	CDD:197581	113/254 (44%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	130/191 (68%)
		Guanylate_cyc	913..1099	CDD:278633	127/185 (69%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:107380	97/477 (20%)
		ANF_receptor	50..410	CDD:279440	85/397 (21%)
		PK_GC-A_B	530..803	CDD:270944	119/303 (39%)
		TyrKc	543..797	CDD:197581	115/269 (43%)
		HNOBA	<812..857	CDD:285003	23/44 (52%)
		CYCc	836..1025	CDD:214485	129/188 (69%)
		Guanylate_cyc	863..1049	CDD:278633	127/185 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3594
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.660