DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and gcy-22

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_508018.2	Gene:	gcy-22 / 180365	WormBaseID:	WBGene00001547	Length:	1058	Species:	Caenorhabditis elegans

Alignment Length:	1139	Identity:	354/1139 - (31%)
Similarity:	559/1139 - (49%)	Gaps:	150/1139 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGL---TISGAISLAVEEVNAGRLRD 83
            :.|||...|  ..|.:..|..:|:|.|:.    |.....|.:   .::||:.:|...:....|..
Worm     9 ICLLFSTYF--LPPVNSAVLQVGFLAAND----NTTELAPFIGWGQVAGALGVAWSRIVEYGLLP 67

  Fly    84 RGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVH----EGRMAAAFNLPMISYYCT 144
            ...::......|...|..::..............:||  .||.    .|.:|...:.|:| .:..
Worm    68 GYETMNLTWVLTNCREADAVGSVINYAEGHAHVVLGP--PCVRPAQVAGSVAKYLDFPLI-LWGP 129

  Fly   145 HRDPS--NKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYL---DDASGQYQPVA---ET 201
            ..|.|  |:.::||.|.|.......:.|::.||..:.||:::.:|.   .|...:..|:.   |.
Worm   130 PFDSSLLNQFEYPTIASTTSSTLYQATSLIRLLEYYKWTEIALIYYVARSDLIPRCTPLISDFEG 194

  Fly   202 ILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYAN--------TRIYLI-LGHYYEHVG 257
            :::...:..::.|               .....:...:||.        .|:.:: |........
Worm   195 LVNNNDNLTITYR---------------RQMSVITNTSYATALRNLKELARVVIVCLESDEARRN 244

  Fly   258 LMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSF 322
            ||:|:...|:  .||.:|. |..|.........:..|  .:....||::|.:.:|.:........
Worm   245 LMISISENGM--DGDEYVY-IMAESRRAGFASSFWNG--TDGKNDLALRAARKFLVMDNQKYNDT 304

  Fly   323 ATFANEVNKYMERPPFNFPN---------PLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSG 378
            .||..||.....||||:.||         .:||.|             ||:.|||.||...:.:|
Worm   305 TTFVQEVRAAFSRPPFSCPNCTNIDPTVSQVGPLG-------------DALLLYAYALNRSIATG 356

  Fly   379 GRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLR------- 436
            .....|:......||..:....| .|.|::|......:.|....|  ..:...|:.:.
Worm   357 NPNPTGTEFCEVAKGMEFLGFTG-KVIINQNSTRTPLFVVYNLDS--TDKEMIVMQITEDLDDSK 418

  Fly   437 -PVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKC-VNYTGEISAAIA 499
             ||.:.::...:|    .|.|.|..      |..|||.|.:.|.|||.|..| .::|.:..|.|.
Worm   419 DPVASSVNYYITL----VATPAQIW------DTWGGTVPLSTPICGFTGTDCPKSFTDQYLAIIL 473

  Fly   500 G----GALLLLSLVSLVLY--RNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLP 558
            |    ..:|:::::|.:::  |:.|.|:|..:.||       |:|.:...:..||.|.|....|
Worm   474 GCTAAALVLIIAVISTIVFLVRSKRQEEERLNQLW-------QVHFSSLVKPPQKNTMHSSRSL- 530

  Fly   559 RRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKS--VDITREMKKE 621
                 |||  :..:::|:::|..|.: |::..|    |....:.|    ||.:  ...|:..:..
Worm   531 -----QST--VTTSTKVTINSKKDTE-RHSFYF----LNNDSVVA----RKHNFRATFTKNDRAM 579

  Fly   622 LKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVI 686
            .:.:|:..:||:|.|||...|.|.:..|..||:||||:|::....:::|..|..|::.|:...:.
Worm   580 FRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIY 644

  Fly   687 YLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELL 751
            |||.|||..||.|.:|.||||.||.||::.|||.|.||.......|          .|:.|||.:
Worm   645 YLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYEVKEQRD----------FLHTAPEHI 699

  Fly   752 RQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF---GETGLTPMQCLQKVLQPQDYLNPYRPSLQ 813
            |.  ::|.: |:..|.|||.|:..|:..::..:   .|| ....:.:.|:  .:...:|.||||:
Worm   700 RD--TNLPI-TKEMDIYSFAIICSELITKKSAWDLENET-FDIEELVYKI--KKGGRSPPRPSLE 758

  Fly   814 PLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVD 878
            ..:.....:|..:|:||.|.|:.||..:.|:|.::.:......|:.|::..::|:||:|||..|.
Worm   759 TEDEHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKSMNHNRSSNLMDHVFNVLEQYASNLEDEVQ 823

  Fly   879 DRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQV 943
            .|..:|.||||::|.||:.|||:.||::||.|..|:||.::.|:|:|||:|.||.:::.||||||
Worm   824 ARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQV 888

  Fly   944 VDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIR 1008
            |:.||||||.||:||..:||||||||||.|:.|||||.|||:.||.||::||..||.|:..|::.
Worm   889 VNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAIKTFRVP 953

  Fly  1009 HRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLL-DR 1072
            |.|..|:.:|:|:|:|||..||||:.|||||||||:|||||||||:|.|.::|.|.:|.:.| :.
Worm   954 HLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECMKFLTEV 1018

  Fly  1073 LGGYHFAERGVISMKGKGDQRTYWLLGEDE-EAR 1105
            :|||....||.:.:||||..:|:|||.:|| ||:
Worm  1019 IGGYQTEPRGEVIVKGKGAVQTHWLLTDDEIEAK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	87/440 (20%)
		ANF_receptor	67..416	CDD:279440	77/378 (20%)
		PK_GC-A_B	570..853	CDD:270944	87/287 (30%)
		TyrKc	597..847	CDD:197581	81/254 (32%)
		HNOBA	<862..907	CDD:285003	21/44 (48%)
		CYCc	886..1078	CDD:214485	112/192 (58%)
		Guanylate_cyc	913..1099	CDD:278633	106/186 (57%)
gcy-22	NP_508018.2	Periplasmic_Binding_Protein_Type_1	28..408	CDD:299141	84/422 (20%)
		ANF_receptor	48..399	CDD:279440	78/387 (20%)
		PKc_like	553..795	CDD:304357	83/265 (31%)
		HNOBA	<791..852	CDD:285003	23/60 (38%)
		CYCc	831..1023	CDD:214485	111/191 (58%)
		Guanylate_cyc	858..1044	CDD:278633	105/185 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020