DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and gcy-32

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	344	Identity:	113/344 - (32%)
Similarity:	177/344 - (51%)	Gaps:	44/344 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   843 IRTKLRPLRKGMRPNIFDNMMAMMEKYAN-NLEA---LVDDRTDQLQEEKKKTDALLHEMLPRCV 903
            :|....||....|..|..|...:.:...| .|||   .::..|.:|:.|::|||::|.:||||.:
Worm   372 MRLTAMPLHDATRDLILLNQQRLSDVEVNLQLEANNEQLETMTRELELERQKTDSILKDMLPRRI 436

  Fly   904 ADQLKKGHKVDP-EHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVE 967
            |.||..|..::. ||  :.::.|.|:..|.....:|:|..:|:.||:::...|.|:....|||||
Worm   437 AQQLLSGEHIEACEH--EATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVE 499

  Fly   968 TIGDAYMVVSGLPLRNGDLHAAEIATMSLHLL----SAVSEFKIRHRPTNR--LLLRIGIHSGPV 1026
            |:.|:||.|||:|....: ||..:..::|.::    |.:.       |.::  .|||||||||.:
Worm   500 TVSDSYMAVSGIPDYTPE-HAENMCHVALGMMWEARSVID-------PVSKTPFLLRIGIHSGTI 556

  Fly  1027 CAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCS-WQCRQLLDRLGGYHFAERGVISMKGKG 1090
            .|||||...|:|||||:||..||:|||.|:..||.|| |..::.:: .|.:.|:.||.|.:|.:|
Worm   557 TAGVVGTVHPKYCLFGETVTLASQMESLGMAGKIQCSKWAYQKAME-TGRFEFSPRGRIDVKQRG 620

  Fly  1091 DQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNSL 1155
            ...||:|                    :|:|.|.|...|...:: .|...|....:.:....|::
Worm   621 LTETYFL--------------------TRSLKKSIWEIIDHDRD-INVNSIEGYEELETAIENAV 664

  Fly  1156 TRSSSLESPKKLRFAAGSL 1174
            |..|:|..|.:...||.|:
Worm   665 TIKSALPRPDQRNSAACSI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	3/9 (33%)
		TyrKc	597..847	CDD:197581	1/3 (33%)
		HNOBA	<862..907	CDD:285003	16/48 (33%)
		CYCc	886..1078	CDD:214485	77/199 (39%)
		Guanylate_cyc	913..1099	CDD:278633	73/193 (38%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002
		HNOBA	226..440	CDD:285003	22/67 (33%)
		CYCc	419..608	CDD:214485	77/199 (39%)
		Guanylate_cyc	452..627	CDD:278633	70/183 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810