Protein Alignment CG10738 and gcy-33

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001256392.1
• Gene: gcy-33 / 179644
• WormBaseID: WBGene00001553
• Length: 947
• Species: Caenorhabditis elegans
• Alignment Length: 621
• Identity: 167/621 - (26%)
• Similarity: 246/621 - (39%)
• Gaps: 158/621 - (25%)

  Fly   693 IRF--HGALCTSNCL--VDS-RWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLR 752
            |:|  .|.:...||:  ::| ..|||.|:..:..   .|.|.:.|...:..|
 Worm   257 IKFTAEGIMVHQNCVFQIESLHPVVKQTEENITV---QINDITEDKVSLEKK------------- 305

  Fly   753 QGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF-----GETGLTPMQCLQKVLQPQD----YLNPY 808
                     |...:.|....|.|.  ..|||.     .||.|....|:...|....    |||.:
 Worm   306 ---------TVMDNEYGLESLPYV--TLRGPITVLKSSETFLLLATCVVDTLDTMFKMGLYLNDF 359

  Fly   809 RPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNL 873
            ..|        ||..|.:                    :..::|.      |.:..|:|......
 Worm   360 GES--------DCNREII--------------------MATIQKS------DTLKTMLENEKRRS 390

  Fly   874 EALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDP-EHYEQVSIYFSDIVGFTAMSAE 937
            |.|. :.|.::.|.||....||.:|:|..||..:.:...||. |.:|.|||.|..:..|:.:|..
 Worm   391 EVLT-EMTREISEAKKTARTLLTQMMPYEVAQTMMRSGSVDHCEAFECVSIGFIRVCDFSKISLF 454

  Fly   938 CTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAV 1002
            ....:||:.||.:|:..|||:..:.||||||||::||:.:|.|.|: |..|..::...|.::|.:
 Worm   455 IEAFEVVNLLNTIYSHLDSIVDTHGVYKVETIGESYMISAGCPYRD-DYDAEMVSDCCLEMVSHI 518

  Fly  1003 SEFKIR-HRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSG-VPLKIHCSWQ 1065
            ..|:.: |....::|::.||.:|||..||||::.|||||||||||||||||||. .|:.|....:
 Worm   519 KSFEYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQR 583

  Fly  1066 CRQLLDR--LGGYHFAERGVISMKGKGDQRTY-----------------------------WLLG 1099
            .:..:::  .|.:....:|.:.:|||||.|.|                             .||.
 Worm   584 TKDRVEKQASGAFRIKPKGNVFVKGKGDMRVYEIEKKKGRARYKKSDPLRKKMVAEKKEAEELLD 648

  Fly  1100 EDEEARTRRTYER----------SQRRGSRA-----LNKFIQGTIKQAQEQANEYGIRSSLKQKN 1149
            ||.|........|          |.||||.:     |||.|..||:...:.:....:....:...
 Worm   649 EDNEGHRSSALSRMSLGESIDSSSSRRGSLSGSQLELNKTIAQTIELTSKASAALDLNMQDENNR 713

  Fly  1150 LPRNSLTRSSSLESPKKL--RFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGST--------- 1203
            .|..|.:.|..:..|:|.  :....|.|.    .||.|:..|::    .:.|.|.|
 Worm   714 PPTWSASHSQDIRKPRKTESKITLNSRLS----SSDLAVSRVET----SKDSDGETPRPTSSELK 770

  Fly  1204 -----------QSRYEETTLSLTLSCQSIEIVGGQH 1228
                       |.:.||.|..  ...|.||.||..|
 Worm   771 EVNRIREEALAQEKEEERTTK--EENQKIEEVGEDH 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	33/173 (19%)
		TyrKc	597..847	CDD:197581	33/167 (20%)
		HNOBA	<862..907	CDD:285003	14/44 (32%)
		CYCc	886..1078	CDD:214485	78/196 (40%)
		Guanylate_cyc	913..1099	CDD:278633	78/219 (36%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902
		HNOBA	204..423	CDD:369471	49/227 (22%)
		CYCc	402..598	CDD:214485	78/196 (40%)
		COG5134	<595..744	CDD:227463	32/152 (21%)
		TDA11	<710..>898	CDD:293689	24/105 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910