Protein Alignment CG10738 and gcy-7

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001360539.1
• Gene: gcy-7 / 179222
• WormBaseID: WBGene00001534
• Length: 1117
• Species: Caenorhabditis elegans
• Alignment Length: 1224
• Identity: 354/1224 - (28%)
• Similarity: 588/1224 - (48%)
• Gaps: 215/1224 - (17%)

  Fly    19 HPLLLLLFLLAFSNFRP--------THGEVFTLGYLTAS--QRRPGNLDYNRPGLTISGAISLAV 73
            :.:.|:|||:.....:|        |.|.|..:|::...  |..|..:.|.    |.:.|.|:||
 Worm     5 YSMSLVLFLVITLLPKPMFPQVATGTTGNVIRVGFIHCRDFQSAPITVGYR----TSAAAASIAV 65

  Fly    74 EEVNAGRLRDRGHSLQFVV-------AETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMA 131
            :.:....|.. |....|.:       :|..|..|..|.:      ..|...|||   .:::..:|
 Worm    66 DRLKRENLMS-GWEFNFTIEFDDCVESEAAGMTVDLIEK------HNVDVIIGP---TMNQPTLA 120

  Fly   132 A-----AFNLPMISYYCTHRDPSNKAD-FPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDD 190
            |     .||.|:|::...:....:..: ||...........:..::.|:|..:.|:|..:.|..:
 Worm   121 AFIVSNYFNRPIIAWGLVNAAQLDDFERFPNAGILSAGQRSLGVAIRAVLKRYEWSQFVYAYFTE 185

  Fly   191 AS--------GQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYL 247
            ..        ...|.|.......:....:.:.||..          |...|||.:   ..:|..:
 Worm   186 EDTEKCVTMRNDLQQVVSYFGDIILAYSIQVADISN----------DGMIEALKK---IQSRGRI 237

  Fly   248 ILGHYYEHVGLMVSLQRRGILSKGDYFVVGID-IEQYDPAKPEKYLRGLL-------------LE 298
            |:....:.:|    |:|:.:|:..:..::|.: :..:...|.:.|:..||             .:
 Worm   238 IVTCMKDGIG----LRRKWLLAAEEAGMIGDEYVYVFSDIKSKGYVVPLLGGGERPSWILSTGSD 298

  Fly   299 DVEPLAVQAFQSYLGIVP-----TASVSFATFANEVNKYMERPPF---------NFPNPLGPFGG 349
            :.:..|::||:..:.|..     :.:.::..|..|:...|:..|:         ||
 Worm   299 ENDTRALKAFKQSIFICDMMGQGSIATNYTIFGQEIIARMKEAPYFCTKDCEGENF--------- 354

  Fly   350 VKQISAE-AAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENG-DA 412
              .::|. |..|:|||:.|..||.::|.:|             :.::||:|..:..|..::. ..
 Worm   355 --TVAATYAGQLHDAVYAYGVALDKMLKAG-------------QIAQYRNATAFMRYFPQSFIGM 404

  Fly   413 AGNYTVLARGSVRNGRNQTVLGLRPVGTFI------HRNSSLSSISKALPHQNLK-----LFSP- 465
            :||.|:..:|:    ||.|:        |:      :.|:.:::|..    :|:.     |:|.
 Worm   405 SGNVTINEKGT----RNPTL--------FLLALDENNNNTRMATIYV----ENMSATFNALYSDE 453

  Fly   466 -IDWV---GGTRPAAAPRCGFGGEKCV-----NYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQ 521
             :.|.   ...||...|.|||.|..|.     .|...:..||....|.:.:....:.:......|
 Worm   454 GVMWASRKNNARPVDVPLCGFTGNLCPKSFVDEYLIWVIVAIVVLFLAITAAACGIYFSIQARRQ 518

  Fly   522 ELDSL--LWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDAD 584
            |::.|  ||:|.|  :.:|:...:|:.:.:      |..|.| ...|..|...:.||..:. ..:
 Worm   519 EIERLNRLWQIPF--IHLHQINSKQKGKGE------HSVRSL-QSGTSTLSSRTTVSFKTE-SRN 573

  Fly   585 FRYTTI-----FTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPP 644
            |.:.::     :.|:       .|.|...:..:|  .:....::.||:...||:..|||.|.|.|
 Worm   574 FLFFSLQRESDYEPV-------VAKKHAYRPRLD--DDKCTFMRSLRNLDQDNLNRFIGLCLDGP 629

  Fly   645 NICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSR 709
            .:..:..:|:|||:.|::....:::||.||.|::.|::.|:::||.|.:.:||.|.:..||:|.|
 Worm   630 QMLSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDR 694

  Fly   710 WVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILL 774
            |.||::::||...:      |.:|....    .||:.||||||   :..:.|::.||.||.||:.
 Worm   695 WQVKISNYGLQDLR------SPEMYEKK----DLLWSAPELLR---AEDIKGSKEGDVYSLGIIC 746

  Fly   775 YEMHVRRGPFG--ETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSE-------CLRECW 830
            .|:..|:|.|.  :....|.:.:  .|..:..|...||.|:     :|...|       .:|:|:
 Worm   747 AELITRKGVFNMEDRKEDPEEII--YLLKKGGLKSPRPDLE-----YDHTIEINPALLHLVRDCF 804

  Fly   831 AERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALL 895
            .|||.:||..:|:|::||.:......|:.|::..|:|.||::||..|.:||.:|.|||||:|.||
 Worm   805 TERPSERPSIETVRSQLRGMNSSRNDNLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDVLL 869

  Fly   896 HEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGH 960
            :.|||:.|||:||.|..|:||.:|||:|:|||:|.||.::::|||||||:.||||||.||.||..
 Worm   870 YRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEK 934

  Fly   961 YDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGP 1025
            :||||||||||.|:.|||||.|||:.|..:||.|||..||::..|::.|.|:.|:.||||::.|.
 Worm   935 HDVYKVETIGDGYLCVSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGS 999

  Fly  1026 VCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKG 1090
            |.||||||.|||:|||||.|||||||||:|.|.|||.|.:..::|..:||:....||.:.:||||
 Worm  1000 VVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKG 1064

  Fly  1091 DQRTYWLLGEDEEARTRRTYERSQRRGSRALNKF------IQGTIKQAQEQANE 1138
            ...|:||.|:...|.:...:..:::...:...:|      .|.|:| :.||.::
 Worm  1065 VMETFWLTGQGTGAVSGARHVSAKKVSKKMYEEFQMDEIHRQETLK-SDEQLSD 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	84/452 (19%)
		ANF_receptor	67..416	CDD:279440	73/399 (18%)
		PK_GC-A_B	570..853	CDD:270944	84/296 (28%)
		TyrKc	597..847	CDD:197581	78/258 (30%)
		HNOBA	<862..907	CDD:285003	24/44 (55%)
		CYCc	886..1078	CDD:214485	116/191 (61%)
		Guanylate_cyc	913..1099	CDD:278633	108/185 (58%)
gcy-7	NP_001360539.1	PBP1_NPR_GC-like	36..438	CDD:380575	86/468 (18%)
		PKc_like	550..822	CDD:389743	86/302 (28%)
		CYCc	860..1049	CDD:214485	114/188 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020