Protein Alignment CG10738 and acy-4

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1223
• Identity: 239/1223 - (19%)
• Similarity: 419/1223 - (34%)
• Gaps: 419/1223 - (34%)

  Fly    27 LLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFV 91
            :|:|.:| |..    .|.|...||::..:..|           |...|:||:||::     ..||
 Worm    56 ILSFYHF-PWE----KLRYRKNSQKKKRSTLY-----------SFYFEQVNSGRIQ-----FSFV 99

  Fly    92 VAETYGEEVVSIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPT 156
            :       ::||                    |:.|                        |.|..
 Worm   100 I-------LLSI--------------------CISE------------------------AAFSA 113

  Fly   157 FARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNT 221
            |.      .:..||::..:|....:.:||.:....  :...:|..|...:..|..|:|...|:..
 Worm   114 FG------AEWLKSLILCILTLVISILSFFHAKRT--ELVCIASIISCVIISACTSMRTSVTYLL 170

  Fly   222 IYH-HGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDP 285
            |:. :..:...|..::..|:|.|  :|:     ..:|:::           || .||.||
 Worm   171 IFSTYSLLPMSFMLMIFSTFALT--FLV-----AFIGVLM-----------DY-NVGFDI----- 211

  Fly   286 AKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGV 350
                     :|...:..:.|....| |...||..|...|| :|..|
 Worm   212 ---------ILTRVMMVILVNVVGS-LVYYPTEFVQRKTF-HETRK------------------- 246

  Fly   351 KQISAEAAYLYD-AVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAA- 413
               ..::..|.| .:|...|.|:.||     |:|.:..|.......:...|.:.:||.:..|.:
 Worm   247 ---CVQSRMLLDKEMHRQEKILLAVL-----PKNIAFEVKKDMQETHEERMFHKIYIRKYEDISI 303

  Fly   414 -----GNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTR 473
                 ..:|.||  |..|.::..::    :.....|...::||     ||.::    |..:|...
 Worm   304 LFADICGFTNLA--SEYNPKDLVLM----LNELFARFDKVASI-----HQCMR----IKILGDCY 353

  Fly   474 PAAAPRCG---FGGEKCVN-----------------------------YTGEISAAIAGGALLLL 506
            ...   ||   :.....:|                             :||:....:.|
 Worm   354 YCV---CGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLG------ 409

  Fly   507 SLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIR 571
                   .:.|:::      :|..|....    |:.|........|:.:         :|...::
 Worm   410 -------LKKWQFD------VWSNDVTLA----NQMESGGLAGRVHITD---------ATRSYLK 448

  Fly   572 TSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAF 636
            .:.:....|..:                        |.|.:: ..::|..|.:.|...:||||.
 Worm   449 GAYILEEGNGGS------------------------RSKFLE-KEKIKTWLVVDRSPDYDNICQ- 487

  Fly   637 IGACTDPPNICIISEYCTRG-----------------SLKDILENEDVKLDNMFIASMVADIIRG 684
              ..|:.|  .::....|||                 |.::.|..|:|.::|     :.:.:.:|
 Worm   488 --EATNHP--VMVPWKSTRGISKQERLTGMSTRTRGASTRNGLSEEEVLVEN-----VDSHLRQG 543

  Fly   685 VIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQ-GIEDSSTDMQHMSAKCLKLLYRAP 748
            :..:|....:      |.:|   ..|.:|        :|| .:|:....:::........||.|.
 Worm   544 IQAIHQENWK------TMHC---KNWSLK--------YKQVRVENKFVRLKYKDIPFQVTLYVAI 591

  Fly   749 ELLRQGPSSLVMGTQRGDAYSF---------GILLYEM------HVRRGPFGETGLTPMQCLQKV 798
            ..:..|   :..|.....::||         .::::.:      |.|........|..:..:|.|
 Worm   592 VAICIG---IKFGLMNLVSFSFVPQMFIVLTSVMIFILTRALIKHARLVSLVIGVLFILLSIQIV 653

  Fly   799 LQPQDYLNPYRPSLQPLETAFDC-VSECLRECWAERPED------------RPDFKT-------- 842
            :....|           |:.|.| |.:|.:..:.:..|.            ..||.|
 Worm   654 ILMGMY-----------ESKFTCDVEKCFKNNYTDFFEIFEICTLATCVILSVDFMTKLLMSMIY 707

  Fly   843 -------IRTKLRPLRKGMRPNIFDNMMAMMEKYAN----------------------------- 871
                   |..||      :|.|.::   |::..|||
 Worm   708 FSSFTVLITAKL------IRINQYE---ALLSTYANFCVLSCLTLLLVVFSTRRSELISRYDFIW 763

  Fly   872 NLEALVDDRTDQLQEEKKKTDALLHEMLPRCVA----DQLKKGHKVDPEHYEQVSIYFSDIVGFT 932
            .|:||  |...|::.:.::..::|..:||..||    :......|:..|..:...|.|:.:..|.
 Worm   764 KLQAL--DEQLQMKRKHEQNRSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFD 826

  Fly   933 AMSAEC----TPLQVVDFLNDLYTCFDSIIGHY-------DVYKVETIGDAYMVVSGLPLRN-GD 985
            ....||    ..::.:..||::.:.||.|:...       .:.|::||...|||.|||..|. ||
 Worm   827 KFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECGD 891

  Fly   986 -LHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTAS 1049
             .|...||..:..||..:....|  ...|...|||||:.|||.|||:|...|.|.::|::||.||
 Worm   892 NSHVEAIALFARELLVKLESTNI--HSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVAS 954

  Fly  1050 RMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1102
            ||:|.||..:|..:.:.:.:|:.| ||:|..||.|::||||...|::||..::
 Worm   955 RMDSGGVAGRIQVTEEVKSILEPL-GYNFECRGQINVKGKGMMETFFLLPPED 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	74/407 (18%)
		PK_GC-A_B	570..853	CDD:270944	54/343 (16%)
		HNOBA	<860..907	CDD:462234	14/79 (18%)
		CYCc	886..1078	CDD:214485	65/208 (31%)
acy-4	NP_504486.4	AcyC	93..455	CDD:441717	84/537 (16%)
		Guanylate_cyc	293..448	CDD:425528	28/204 (14%)
		Guanylate_cyc	807..1003	CDD:425528	69/198 (35%)