Protein Alignment CG10738 and gcy-18

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1227
• Identity: 350/1227 - (28%)
• Similarity: 557/1227 - (45%)
• Gaps: 241/1227 - (19%)

  Fly    21 LLLLLFLLAFSNF-------------------------------RPTHGEVFTLGYLTASQRRPG 54
            |..|||:|.|.|.                               ...|..|..:|::.|....|.
 Worm     2 LKTLLFILIFFNIPIIAIEEIPDIKENGEKSSYTQFDNGAKLEVNKEHKRVIKIGHIGAVGVMPN 66

  Fly    55 N---LDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALW-TQQVA 115
            :   |:.::..|...|.:...:|             .:.|..:...|....:...|.|: ..||.
 Worm    67 DARILNISKENLIEEGLVGDDIE-------------FEIVSRQACSESFEGVAVAAELYHVHQVR 118

  Fly   116 AYIGPQETCVHE----GRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDT-QISKSVVALL 175
            |:|||.  |..|    .:||..:|:|:|||.......|:::.:.|.||....:| .|:::.||||
 Worm   119 AFIGPY--CAAELEAVTKMATFWNIPIISYSSVPNAVSDRSVYKTLARVSSKNTNSIAEATVALL 181

  Fly   176 LAFNWTQVSFLYLDDASGQYQPVA----------ETILSTL-----TDAGVSIRDIRTWNTIYHH 225
            |.:.|.:|: :..:..|..::.|:          .||:..:     |||          |.:.:.
 Worm   182 LHYKWLKVA-IATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDA----------NEMMNS 235

  Fly   226 GFMDNPFEALVEQTYANTRIYLILGHYYEHVG---LMVSLQRRGILSKGDYFV------------ 275
            |.:.:        ..||.||.:.|....:.:.   :..:...|...::..|.:
 Worm   236 GQLGD--------LAANARIIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTP 292

  Fly   276 -VGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKY-MERPPF 338
             :|.|.|.....| :.|...::::|     |..|...:         .::|..::.|: |::...
 Worm   293 WIGADGEMLQRVK-DHYANAIIVDD-----VNGFDDSV---------VSSFVEKIEKHGMQKSDI 342

  Fly   339 NFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVL---DSGGRPRNGSAIVAAIKGSRYRSAM 400
            :..|..|           ..:|:|::.|||.|:.:||   |:.....||..|...::..::...:
 Worm   343 DVTNING-----------YLHLFDSLKLYALAIRKVLNETDNEAYVTNGQFIWNRMRRMKFEGVV 396

  Fly   401 GYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRP----VGTFIHRNSSLSSISKALPHQN-- 459
            . ....:||.||....|||...........:...:.|    |...::..|.|.|....|.:::
 Worm   397 S-RSSSEENKDAGAIGTVLMDDVADRAPIFSAFYISPNRDKVMKMVNMESELISNCDGLKNKSGC 460

  Fly   460 --LKL------FSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRN 516
              ||:      |.|.:  .|:.|...|.||:.|::| :|..|||   .|..::||.|:|:|.:..
 Worm   461 FQLKINDIKSGFWPSE--DGSMPLDEPICGYRGQRC-SYLLEIS---VGSLIILLILISVVFFFL 519

  Fly   517 WRY--EQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSS 579
            :||  .::|:.:.|:|...::|..: |.:.:|......:...|......|..|.:|..:
 Worm   520 FRYCENKQLEKMPWRIFHDDLQFID-EEQVKSMMSVGSVTTKLSNIQTGQKQHAIIGVN------ 577

  Fly   580 NPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGAC-TDP 643
                  .:||...    ||         :::.:...:|..:.|..::.|.|||:..|:||. .:.
 Worm   578 ------THTTYHR----YK---------QRRPIKFIKEDMQLLTQMKQAVHDNLNPFLGAAFNEK 623

  Fly   644 PNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDS 708
            ..:.::.::|:||:::||:.|.:|.||..|..:.|.||..|:.|||.|||.:||:|....||:|.
 Worm   624 EEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDITLGLEYLHASPIGYHGSLTPWCCLIDR 688

  Fly   709 RWVVKLTDFGLFA-----FKQG-IEDSS---TDMQHMSAKCLKLLYRAPELLRQGPSSLVMG--- 761
            .|:|||:|:|:..     .||| ||.::   :|.:..:::...::|.|||||:...::...|
 Worm   689 NWMVKLSDYGIANPLERWEKQGAIEIAAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQ 753

  Fly   762 ---------TQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYL----NPYRPSLQ 813
                     .|.||.||||:::||:..|..||.:.        ..:.:..|||    ....|.:|
 Worm   754 SWVKQSMLRRQAGDIYSFGMVMYEILFRSLPFRDN--------TNISELVDYLADGSKTVSPEIQ 810

  Fly   814 PLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVD 878
            ........::..||:||:|.||.||..:.:|.....:.| .:.::.|.||.|||:||||||.||.
 Worm   811 NQMGLHPDLNALLRDCWSENPEIRPSIRRVRLNTEMVLK-TKGSLVDQMMKMMEQYANNLEKLVA 874

  Fly   879 DRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQV 943
            :||..|:|...:.|.||.::||..||::||.|..|.|:.|...:|.||||||||.:.:..|||:|
 Worm   875 ERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEV 939

  Fly   944 VDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIR 1008
            |:.||.|||.||..|.....|||||||||||||||:|..|...|:..||..:|.:...::.::|.
 Worm   940 VNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIP 1004

  Fly  1009 HRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRL 1073
            ||||:|:..|.|.|:|.|.||||||..|||||||||||.:|||||:|.|..|..|.:...   .:
 Worm  1005 HRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHM---HI 1066

  Fly  1074 GGYH----FAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRALNKFIQ 1126
            ..:|    ..|||.:.:||||..||:||  ||             |.|..:...:||
 Worm  1067 RAHHPVFTTTERGEVQVKGKGTCRTFWL--ED-------------RVGDASTTNYIQ 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	89/447 (20%)
		PK_GC-A_B	570..853	CDD:270944	86/308 (28%)
		HNOBA	<860..907	CDD:462234	25/46 (54%)
		CYCc	886..1078	CDD:214485	95/195 (49%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575	87/442 (20%)
		Protein Kinases, catalytic domain	549..846	CDD:473864	90/329 (27%)
		CYCc	882..1073	CDD:214485	95/193 (49%)