DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	1218	Identity:	379/1218 - (31%)
Similarity:	536/1218 - (44%)	Gaps:	302/1218 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLLLLLFLL----AFSNFRPTHGEVFTLGYLTASQRRPGNLD----YNRPGLTISGAISLAVEEV 76
            |.||||.||    |.|       .||.:|.|     .|...|    ..||.|    |..||...:
Mouse    39 PGLLLLLLLPSPSALS-------AVFKVGVL-----GPWACDPIFARARPDL----AARLAANRL 87

  Fly    77 NAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWT--QQVAAYIGP--QETCVHEGRMAAAFNLP 137
            |.....|.|.  :|.|| ...|..::.....|:.:  .:|:..:||  ...|.....:|....:.
Mouse    88 NRDFALDGGP--RFEVA-LLPEPCLTPGSLGAVSSALSRVSGLVGPVNPAACRPAELLAQEAGVA 149

  Fly   138 MISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDD------------ 190
            ::.:.|    |..:|    ...|.|..|..:.::..||.||.|.:|:.:....
Mouse   150 LVPWGC----PGTRA----AGTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRALST 206

  Fly   191 ---ASGQYQPVA-ETILSTLTDAGV-----SIRD-----------IRT-WNTIYHHGFMDNPFEA 234
               |.|  .||| .|.:.|...:|.     .|||           :|. |......|....|...
Mouse   207 ALRARG--LPVALVTSMETSDRSGAREALGRIRDGPRVRGKLPSRVRARWVGPAESGQRSEPASV 269

  Fly   235 LVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLED 299
            .|...                   :|.:....:|..|:               .::|    |||.
Mouse   270 SVRSA-------------------VVIMVMHSVLLGGE---------------EQRY----LLEA 296

  Fly   300 VEPLAVQAFQSYLGIVPTASVSFA------TFANEVNKYMER-------------PPFNFPNPLG 345
            .|.||:.  ...|..:|..::.:|      ..|..||....|             ||
Mouse   297 AEELALT--DGSLVFLPFDTLHYALSPGPEALAAFVNSSQLRRAHDAVLTLTRRCPP-------- 351

  Fly   346 PFGG--------------------VKQISAEAAYLYDAVHLYAKALMEVLDS-GGRPRNGSAIVA 389
              ||                    :||:|.....:||||.|.|..:.....: ||...:|:::..
Mouse   352 --GGSVQDSLRRAQEHQELPLDLNLKQVSPLFGTIYDAVFLLAGGVKRARTAVGGGWVSGASVAR 414

  Fly   390 AIKGSRYRSAMGY--------HVYIDENGDAAGNY---TVLARGSVRNGRNQTVLG-LRPVGTFI 442
            .::.::.....|.        .|.:|.  ||:|..   |.|.         ..||| ||..||.:
Mouse   415 QVREAQVSGFCGVLGRTEEPSFVLLDT--DASGEQLFATHLL---------DPVLGSLRSAGTPM 468

  Fly   443 HRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLL-L 506
            |           .|.            ||..|...|.|.|..:...|...|......|..|:: :
Mouse   469 H-----------FPR------------GGPAPGPDPSCWFDPDVICNGGVEPGLVFVGFLLVIGM 510

  Fly   507 SLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHL-----PRRL----- 561
            .|....|                                 ....||.|.|:     |.::
Mouse   511 GLTGAFL---------------------------------AHYLRHRLLHMQMASGPNKIILTLE 542

  Fly   562 -------PPQSTHPLIRTSQVSLSSNPDADFRYTTI----FTPIGLYKGQLYAIKKV-RKKSVDI 614
                   |..|:..:::.|:.||::...:|.|....    .|.:|||:|....:||. .:..:.|
Mouse   543 DVTFLHPPGGSSRKVVQGSRSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLKKFPGEHHMAI 607

  Fly   615 TREMKKELKLLRDARHDNICAFIG----ACTDPPN------ICIISEYCTRGSLKDILENEDVKL 669
            ....|.....||:.||:|:..::|    ...|.|.      :.::||:|.||||.|:|...::||
Mouse   608 RPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKL 672

  Fly   670 DNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFG----LFAFKQGIEDSS 730
            |.||.:|::.|:|:|:.|||...:. ||.|.:.||:||.|:|:|:||.|    |.|.:...|..|
Mouse   673 DWMFKSSLLLDLIKGMRYLHHRGVA-HGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPS 736

  Fly   731 TDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCL 795
            .:.|         |:.||||||. ||....||..||.:|..|::.|:..|..|:....|||.:.:
Mouse   737 AEDQ---------LWTAPELLRD-PSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVI 791

  Fly   796 QKVLQPQDYLNPYRPSLQPLETAFDCVSECLR---ECWAERPEDRPDFKTIRTKLRPLRKGMRPN 857
            |:|..|.       |..:||.:......||::   :||||.||.||.........:.:.||.:.|
Mouse   792 QRVRSPP-------PLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTN 849

  Fly   858 IFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVS 922
            |.|:|:.|:|:|::|||.|:.:||::|::||:|||.||.:|||..||:.||.|..|:||::|:|:
Mouse   850 IIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVT 914

  Fly   923 IYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLH 987
            :|||||||||.:||...|::|||.||||||.||:|||.:||||||||||||||.||||.|||..|
Mouse   915 LYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRH 979

  Fly   988 AAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRME 1052
            |||||.|||.:||||..|::||.|...:.:|||:||||..||||||.||||||||||||||||||
Mouse   980 AAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRME 1044

  Fly  1053 SSGVPLKIHCSWQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYWLLG 1099
            |:|:|.:||.:....::|..|. |:....||...:||||.:.||||:|
Mouse  1045 STGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVG 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	99/492 (20%)
		ANF_receptor	67..416	CDD:279440	83/433 (19%)
		PK_GC-A_B	570..853	CDD:270944	98/304 (32%)
		TyrKc	597..847	CDD:197581	90/267 (34%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	123/192 (64%)
		Guanylate_cyc	913..1099	CDD:278633	118/186 (63%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	97/489 (20%)
		PK_GC-2D	570..845	CDD:270945	95/292 (33%)
		HNOBA	<854..899	CDD:400168	23/44 (52%)
		CYCc	879..1070	CDD:214485	123/190 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820