DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus

Alignment Length:	1139	Identity:	368/1139 - (32%)
Similarity:	535/1139 - (46%)	Gaps:	195/1139 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQ 89
            |.|||::.      |.||||.|     .|.:.|........|.|..|||::||.......|..|.
Mouse    60 LSLLAWAR------ETFTLGVL-----GPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLD 113

  Fly    90 FVVAETYGEEVVSIRQTAALWTQQVAAYIGPQET--CVHEGRMAAAFNLPMISYYCTHRDPSNKA 152
            |.|..| |.:......|.......|||::||...  |.....:|..:...:.|:.|  ..|....
Mouse   114 FKVLPT-GCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWAC--EAPEGGG 175

  Fly   153 DF-PTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDI 216
            |. ||.    |....:   :::::..|.|.:.:.:      ..:|.:..|....|..|      .
Mouse   176 DLVPTL----PSAADV---LLSVMRHFGWARWAIV------SSHQDIWVTTAQQLATA------F 221

  Fly   217 RTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYY--------EHVGLMVSLQRRGIL----S 269
            ||      ||.......:|.......|.:...|...:        .|..|:..|::..:|    .
Mouse   222 RT------HGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWE 280

  Fly   270 KG--DYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGI-VPTASVSFATFANEVNK 331
            :|  |..:|.:..:....|.|......|:|:|..||. :|:.:.|.: :.::..|.|..|.|::
Mouse   281 EGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQ-EAYDAVLTVSLESSPESHAFTATEMS- 343

  Fly   332 YMERPPFNFPNPLGPFGGV------KQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAA 390
                            ||.      :|:|.....:||||.|.|.||      .....:|:.:..|
Mouse   344 ----------------GGATANLEPEQVSPLFGTIYDAVILLAHAL------NRSETHGAGLSGA 386

  Fly   391 IKGSRYR----SAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSI 451
            ..|...|    :.....:..|..|.....|.:|.    .:|.     |.:.|.|.|...|:
Mouse   387 HLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILD----TDGE-----GSQLVPTHILDTST---- 438

  Fly   452 SKALPHQNLKLFSPIDWVGGTRPAAAPRCGFG-GEKCVNYTGEISA----------AIAGGAL-- 503
                 .|...|..||.:.||:.||....|.|. ...|:.....:.:          |:.||.|
Mouse   439 -----WQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAY 498

  Fly   504 -LLLSLVSLVL----YRNWRYEQELDSLLWKIDFR---EVQIHENEREQQSQKQTRHLLNHLPRR 560
             :.|.|..|.|    :|.....||| :.|.:...|   .|......|........|.:.....|.
Mouse   499 FIRLGLQQLRLLRGPHRILLTSQEL-TFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARS 562

  Fly   561 LPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKK--------VRKKSVDITRE 617
            ||....|                        |.:.||:|:...:||        :|..|:...|:
Mouse   563 LPAFLEH------------------------TNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRK 603

  Fly   618 MKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADII 682
                   ||:.||:|:.||:|....|....::.|:|.||||:|:|:||:::||..|.||::.|:|
Mouse   604 -------LREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLI 661

  Fly   683 RGVIYLHDSPIRF-HGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCL----K 742
            ||:.|||..  || ||.|.:.||:||:|:|:|:||.|...|.:         .|.|::..    :
Mouse   662 RGLRYLHHR--RFPHGRLKSRNCVVDTRFVLKITDHGYAEFLE---------SHCSSRPQPAPEE 715

  Fly   743 LLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNP 807
            ||:.|||||| ||..   .|.:||.:|..|:|.|:..|..|:...||:..:.::||..|....
Mouse   716 LLWTAPELLR-GPGK---ATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLC-- 774

  Fly   808 YRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANN 872
             ||.:.|.:...:|: :.::.||.|.|:|||....|.|:.:.:.:|.:.::.|:|:.|:|||:.:
Mouse   775 -RPLVSPDQGPLECI-QLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSES 837

  Fly   873 LEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAE 937
            ||.||.:||::|:.|::||:.||.:|||..||..||.|..|:||:::||:||||||||||.:||.
Mouse   838 LEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISAL 902

  Fly   938 CTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAV 1002
            ..|::||.|||||||.||:::..:||||||||||||||.||||.|||:.||||||.::|.:||..
Mouse   903 SEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYA 967

  Fly  1003 SEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCR 1067
            ..|::||.|...:.:|.|:||||..||||||.|||||||||||||||||||:|:|.:||.|....
Mouse   968 GNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTV 1032

  Fly  1068 QLLDRLG-GYHFAERGVISMKGKGDQRTYWLLGE 1100
            |.|..|. ||....||...:||||.:.||||.|:
Mouse  1033 QALLSLDEGYKIDVRGQTELKGKGLEETYWLTGK 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	91/427 (21%)
		ANF_receptor	67..416	CDD:279440	78/376 (21%)
		PK_GC-A_B	570..853	CDD:270944	95/295 (32%)
		TyrKc	597..847	CDD:197581	93/262 (35%)
		HNOBA	<862..907	CDD:285003	22/44 (50%)
		CYCc	886..1078	CDD:214485	117/192 (61%)
		Guanylate_cyc	913..1099	CDD:278633	114/186 (61%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	94/448 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557		4/27 (15%)
		PK_GC-2D	554..818	CDD:270945	99/313 (32%)
		CYCc	855..1044	CDD:214485	116/188 (62%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		24/40 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920