Protein Alignment CG10738 and gucy2d

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: XP_005165318.1
• Gene: gucy2d / 140426
• ZFINID: ZDB-GENE-011128-9
• Length: 1141
• Species: Danio rerio
• Alignment Length: 1114
• Identity: 351/1114 - (31%)
• Similarity: 543/1114 - (48%)
• Gaps: 194/1114 - (17%)

  Fly    68 AISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTA--ALWTQQVAAYIGPQET--CVHEG 128
            |..||:..:|.....::|:...:.|   ..|:..|.|..|  |......:|::||...  |....
Zfish    99 AARLAMSRINKDPELNKGYWYDYTV---INEDCSSSRGLARFAELEGYGSAFLGPANPGYCTAAT 160

  Fly   129 RMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASG 193
            .:|..:|..::|:.|...:...:. :|||.|..|..:::..||   |..|.|..|..:   .|.|
Zfish   161 LLAKNWNKGILSWGCLKAEMDEEM-YPTFLRPLPLSSRVLFSV---LRFFRWAHVGIV---TAEG 218

  Fly   194 -QYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANT---RIYL------I 248
             .::.....:.::|...|:.:..:.|...     ..:.|.:||  |...:|   |:.:      :
Zfish   219 DMWEATGHELAASLRALGLPVGKVVTMEQ-----DKEGPRQAL--QAIRDTDRVRVVIMCMHSAL 276

  Fly   249 LGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYD-PAKPEKY--------LR----GLLLEDV 300
            :|...::..|..:|:.| ::.:| |..:..|...|. |.:..||        ||    |:|...:
Zfish   277 IGGEEQYQLLTTALEMR-MIDRG-YIFIPYDTLLYSLPYENVKYPILANDSKLRRAYDGVLTVTM 339

  Fly   301 EPLAVQAFQSYLGIVPTASVSF----ATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLY 361
            :    |..|::......|..||    :|.|.||.::           :.||.|.         :|
Zfish   340 D----QGEQNFYEAFNAAQESFEIRGSTSAEEVTRW-----------VSPFFGT---------IY 380

  Fly   362 DAVHLYAKALMEV-LDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAG---NYTVL-AR 421
            :.::..|.|..:. ..||||..:|..:.....|..:.   |::..|....:..|   .|.|| :.
Zfish   381 NMIYYTAMAAEQSRASSGGRWVSGDLLSQNEGGFEFD---GFNQRISGGTNGEGMQVRYAVLDSD 442

  Fly   422 GSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEK 486
            ||               |:.::|..:|.:......:..||.........|..|::...|.|  ..
Zfish   443 GS---------------GSSLYRTHALEASHTYGKYGGLKYLGKSIHFAGASPSSDANCWF--SP 490

  Fly   487 CVNYTGEISAA------------IAGGALLLL-------------------SLVSLVLYRNWRYE 520
            .:..:|.:...            |||..:|.|                   |...:||
Zfish   491 YIACSGGLDGVTLFFLLMFFIVLIAGAGILFLQVRKYGAGGFFGAFIGGGGSPTKIVL------- 548

  Fly   521 QELDSLLW---KIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPD 582
             .||.|::   .:..|::......:.|...|..||.:                 :.:..::|.|:
Zfish   549 -TLDDLVFINTTLSRRKLNDESMLKSQLDVKTPRHSV-----------------SGRSYITSTPE 595

  Fly   583 ADFRYTTIFTPIGLYKGQLYAIKK--VRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPN 645
            .        :.:.:::|....:||  ......:|:...:.....|||.||:|:..|:|...|...
Zfish   596 T--------SNVAVFEGDWVWLKKCPCADSITEISESTQTIFVKLRDMRHENLNLFLGLFMDTGI 652

  Fly   646 ICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRW 710
            ..|::|:||||||:|:|.||:::||.||.:|::.|:|||:.|||:..| .||.|.:.||:||.|:
Zfish   653 FGIVTEHCTRGSLEDLLNNEEMRLDWMFKSSLLLDLIRGMKYLHNRGI-IHGRLKSRNCVVDGRF 716

  Fly   711 VVKLTDFGLFAFKQ-------GIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAY 768
            |:|:||:|   |.:       .:||::.:.|         .:.|||:|| .|.....||..||.|
Zfish   717 VLKVTDYG---FNEILNCQNIILEDNAPEDQ---------FWTAPEILR-NPDLKKKGTYPGDVY 768

  Fly   769 SFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAER 833
            ||.|::.|:..|..||....:.|.:.::||..|....   ||::...|...| |.:.:::.|:|.
Zfish   769 SFSIIMQEVISRCAPFCMLDMPPEEIIEKVRSPPPLC---RPTVSMDEAPLD-VIQLMKQAWSEE 829

  Fly   834 PEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEM 898
            ||.||.|:.|..:.:.:.||.:.||.|:|:.|:|:|::|||.|:.:||::|:.|::||||||.:|
Zfish   830 PEQRPTFEDIFRQFKSMNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVERQKTDALLAQM 894

  Fly   899 LPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDV 963
            ||:.||..||.|..|.|||:.:|::|||||||||.:||...|::|||.||||||.||.||..:||
Zfish   895 LPKSVALALKTGKPVKPEHFAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDV 959

  Fly   964 YKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCA 1028
            ||||||||||||.||:|.|||..||||:|.|||.:|..:..||:||.|..::.:|||:|||||.|
Zfish   960 YKVETIGDAYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGLHSGPVVA 1024

  Fly  1029 GVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLG-GYHFAERGVISMKGKGDQ 1092
            |||||||||||||||||||||||||:|:|.:||.:.....:|:.|. ||....||...:||||.:
Zfish  1025 GVVGLKMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVE 1089

  Fly  1093 RTYWLLGED 1101
            .|:||:|.|
Zfish  1090 ETFWLVGRD 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	86/408 (21%)
		PK_GC-A_B	570..853	CDD:270944	92/291 (32%)
		HNOBA	<860..907	CDD:462234	24/46 (52%)
		CYCc	886..1078	CDD:214485	121/192 (63%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF-like	78..470	CDD:380594	90/431 (21%)
		PK_GC-2D	581..849	CDD:270945	94/310 (30%)
		HNOBA	<858..903	CDD:462234	23/44 (52%)
		CYCc	883..1075	CDD:214485	121/191 (63%)