Protein Alignment CG10738 and gucy2f

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_571939.2
• Gene: gucy2f / 140424
• ZFINID: ZDB-GENE-011128-7
• Length: 1107
• Species: Danio rerio
• Alignment Length: 1153
• Identity: 373/1153 - (32%)
• Similarity: 579/1153 - (50%)
• Gaps: 201/1153 - (17%)

  Fly    21 LLLLLFLLAFSNFRPTHGEVFTLGYLTASQRRPGNLDYNRPGLTISGAISLAVEEVNAGRLRDRG 85
            |.::|.:|.|.  |.....||.:|.:     .|.|.|.|......:.|..|||..:|.....|.|
Zfish    40 LWIILGVLTFP--RCVQCLVFKVGII-----GPWNCDPNYAKSLPAIASRLAVGRINNDFSLDLG 97

  Fly    86 HSLQFVVAETYGEEVVSIRQTAALWTQQVA-AYIGPQET--CVHEGRMAAAFNLPMISYYCTHRD 147
            .::.||:.:...|  .|...|:.:..:.|| |::||...  |.....|:..::..:.|:.|.:.:
Zfish    98 CTMDFVILQEACE--TSKALTSFVQYENVADAFVGPTNPGYCNAAALMSKNWDKSLFSWACVNHE 160

  Fly   148 PSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSF------LYLDDAS-------------- 192
            ......:||||||.|...::..:|   |..|.|..:..      :::|.|:
Zfish   161 LDRVQGYPTFARTLPSPLRVLFNV---LKFFRWANIGIVSSNEDIWIDTAAKLASALRNRGLPVG 222

  Fly   193 -----GQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHY 252
                 |....:.|..|.::.:||    ||:......|...:....:|    |:. |:.|
Zfish   223 IVTSMGNNDTMLENTLMSIKNAG----DIKVIIMCMHSVLIGGEQQA----TFL-TKAY------ 272

  Fly   253 YEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT 317
              .:|          |:.|.|..:..|...|  :.|...:....|::...|: :|:.:.|.|  |
Zfish   273 --DMG----------LASGRYVFIPYDTLLY--SLPYINITYYPLQNNSKLS-KAYDAVLTI--T 320

  Fly   318 ASVSFATFANEVNKYMERPPFNFPNPLG-------PFGGVKQISAEAAYLYDAVHLYAKALMEVL 375
            ......|| ||.        ||....||       |    :|:|.....:|::::|.||: |...
Zfish   321 LDSDIMTF-NEA--------FNAAKQLGELMVTQEP----EQVSPLFGTIYNSLYLLAKS-MHNA 371

  Fly   376 DSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGT 440
            ...||..:|:.:....:...: :.....:..||.|:...||              .:|.....||
Zfish   372 RRAGRWLSGTNLAYFTRNITF-TGFNQDIQTDEQGNGQTNY--------------VILDTEAWGT 421

  Fly   441 FIHRNSSLSSISKALPHQNLKLFSP--IDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGA- 502
            .::|...:...|      :|.||:.  |.:.|.:.|.:..||.|          |.:|...||.
Zfish   422 QLYRCFLVDMTS------DLVLFAGRFIHFPGESPPPSDSRCWF----------EDNAICTGGVD 470

  Fly   503 ------------LLLLSLVSLVLYRNWRYEQ------------ELDSLLW--------KIDFREV 535
                        :::|..:.|.|:...|.:|            .|:.|.:        ||...::
Zfish   471 IIYVIIAFVIVLIIVLGSIGLSLFIRRRIQQIQLIKGPNRILLTLEDLTFINPQLSKRKITLEDL 535

  Fly   536 QIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQ 600
            ...::..|::|.......:|.:     ..:||   .||.|::.   :.|:.:...||     :|.
Zfish   536 SDSKSYIEEKSTGDRSRSVNSM-----ATATH---ETSNVAVY---EGDWVWLKKFT-----EGH 584

  Fly   601 LYAIKKVRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENE 665
               .|:|::.:..|..:||       |.|::|:..|:|..||.....|::|:|:||||.|:|.|:
Zfish   585 ---FKEVKQSTTKIFTKMK-------DLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRND 639

  Fly   666 DVKLDNMFIASMVADIIRGVIYLH--DSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIED 728
            |||||.||.:|:|.|:|:|:.|||  :.|   ||.|.:.||:||.|:|:|:||:|   :.:.:|.
Zfish   640 DVKLDWMFKSSLVLDLIKGMKYLHHREFP---HGRLKSRNCVVDGRFVLKITDYG---YNEILET 698

  Fly   729 SSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQ 793
            .....:.:..:  .|.:.|||.||. |.|...||.:||.|||.|:|.|:.||..|:...||:|.:
Zfish   699 QKAPKETLPPE--DLFWTAPEHLRD-PESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEE 760

  Fly   794 CLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNI 858
            .::||.:|....   ||::.|.:...:|: :.:::||:|:|:.||.|..|..:.:.:.||.:.||
Zfish   761 IIRKVKKPPPMC---RPTVAPDQAPLECI-QLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTNI 821

  Fly   859 FDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSI 923
            .|:|:.|:|:|::|||.|:.:||::|:.||::|:.||.||||..||:.||.|..|:||:::||:|
Zfish   822 IDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVTI 886

  Fly   924 YFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHA 988
            |||||||||.:|:...|::|||.|||||:.||:::|.:||||||||||||||.||||.:||:.||
Zfish   887 YFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHA 951

  Fly   989 AEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMES 1053
            ||||.|||::||:|..||:||.|...:.:||||||||..||||||.|||||||||||||||||||
Zfish   952 AEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMES 1016

  Fly  1054 SGVPLKIHCSWQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYWLLGE 1100
            :|:|.:||.:....|:|..|. ||....||...:||||.:.||||:|:
Zfish  1017 TGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGK 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	91/434 (21%)
		PK_GC-A_B	570..853	CDD:270944	98/284 (35%)
		HNOBA	<860..907	CDD:462234	23/46 (50%)
		CYCc	886..1078	CDD:214485	121/192 (63%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF-like	59..440	CDD:380594	96/457 (21%)
		PK_GC-2D	551..816	CDD:270945	101/303 (33%)
		HNOBA	<825..870	CDD:462234	22/44 (50%)
		CYCc	850..1042	CDD:214485	121/191 (63%)