Protein Alignment CG10738 and Gucy2f

DIOPT Version :10

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_446283.1
• Gene: Gucy2f / 116556
• RGDID: 620439
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 1084
• Identity: 357/1084 - (32%)
• Similarity: 550/1084 - (50%)
• Gaps: 146/1084 - (13%)

  Fly    68 AISLAVEEVNAGRLRDRGHSLQFVVAETYGEEV-VSIRQTAALWTQQVAA-YIGPQET--CVHEG 128
            |.:||:|.::.....||.:|.::|:   ..|:. .|...|:.:..||:|: ::||...  |....
  Rat    75 AAALAIERISRDMSFDRSYSFEYVI---LNEDCQTSKALTSFISHQQMASGFVGPANPGYCEAAS 136

  Fly   129 RMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASG 193
            .:..:::..:.|:.|.:.:..||..:|||:||.|...::   :|.::..|.|.....:..|:  .
  Rat   137 LLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDE--D 196

  Fly   194 QYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLIL--------- 249
            .:...|..:.|.|...|:.:..:.|      .|......:..::|.....||.:|:
  Rat   197 IWVHTANQVSSALRSHGLPVGVVLT------SGQDSRSIQKALQQIRQADRIRIIIMCMHSALIG 255

  Fly   250 GHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGI 314
            |....|   .:.|.....::.|.|..|..|:..|  :.|.|:....:|.:.:.|. :|:.:.|.|
  Rat   256 GETQTH---FLELAHDLKMTDGTYVFVPYDVLLY--SLPYKHSPYQVLRNNQKLR-EAYDAVLTI 314

  Fly   315 -VPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSG 378
             |.:...:|.....|.....|.|.....:.:.|..|.         :|::::..|:|:...|
  Rat   315 TVESHEKTFYEAFTEAAAGGEIPEKLDSHQVSPLFGT---------IYNSIYFIAQAMSNAL--- 367

  Fly   379 GRPRNGSAIVAAI-KGSRYRSAMGYHVYI--DENGDAAGNYTVLARGSVRNGRNQTVLG------ 434
              ..||.|..|:: :.||.....|::..|  |.||:....|.:|.    .||:...:.|
  Rat   368 --KENGQASAASLTRHSRNMQFYGFNQLIRTDSNGNGISEYVILD----TNGKEWELRGTYTVDM 426

  Fly   435 ----LRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFG-GEKCVNYTGEI 494
                ||..||                        ||.:.||...:|..:|.|. |:.|   .|.|
  Rat   427 ETELLRFRGT------------------------PIHFPGGRPTSADAKCWFAQGKIC---QGGI 464

  Fly   495 SAAIAGGA--LLLLSLVSL-----VLYRNWRYEQELDS----LLWKIDFREVQIHENEREQQSQK 548
            ..|:|...  .|||:|:|:     .:.|.....|.:..    ||...|...:..|...:......
  Rat   465 DPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRAS 529

  Fly   549 QTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIGLYKGQLYAIKK------- 606
            .:..:::.:      ||.    |:.::|.||.......|..  :.|.:|:|....:||
  Rat   530 VSFQIISEV------QSG----RSPRLSFSSGSLTPATYEN--SNIAIYQGDWVWLKKFPPGDFG 582

  Fly   607 ----VRKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDV 667
                ::..:.|:       .::::|.||:|:...:|...|.....|:||:|:|.||:|||..:||
  Rat   583 DIKSIKSSASDV-------FEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTQDDV 640

  Fly   668 KLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTD 732
            |||.||.:|::.|:|:|:.|||.... .||.|.:.||:||.|:|:|:||:|   |...:|.....
  Rat   641 KLDWMFKSSLLLDLIKGMKYLHHREF-IHGRLKSRNCVVDGRFVLKVTDYG---FNNILEMLRLS 701

  Fly   733 MQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQK 797
            .:..|.:  :||:.|||||| .|..:.:|:..||.|||.|::.|:.||..||....|:..:.:.:
  Rat   702 EEEPSEE--ELLWTAPELLR-APGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLSAKEVIDR 763

  Fly   798 VLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNM 862
            :..|...   |||.:.|.....:|: :.:::||||..|.||.|..|..:.:...||.:.||.|:|
  Rat   764 LKMPPPV---YRPVVSPEFAPPECL-QLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSM 824

  Fly   863 MAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSD 927
            :.|:|:|::|||.|:.:||::|:.||:||:.||.:|||..||:.||||..|:||.::.|::||||
  Rat   825 LRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSD 889

  Fly   928 IVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIA 992
            |||||.:||...|::|||.||||||.||:|||.:||||||||||||||.||||.|||..||||||
  Rat   890 IVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIA 954

  Fly   993 TMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVP 1057
            .|||.:||:|..||:||.|...:.:|||:|:|||.||||||.|||||||||||||||||||:|:|
  Rat   955 NMSLDILSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLP 1019

  Fly  1058 LKIHCSWQCRQLLDRLG-GYHFAERGVISMKGKGDQRTYWLLGE 1100
            .:||.|.....:|..|. ||....||...:||||.:.|:||:|:
  Rat  1020 YRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVGK 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_SAP_GC-like	41..441	CDD:380593	86/399 (22%)
		PK_GC-A_B	570..853	CDD:270944	94/293 (32%)
		HNOBA	<860..907	CDD:462234	23/46 (50%)
		CYCc	886..1078	CDD:214485	124/192 (65%)
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	85/397 (21%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	93/289 (32%)
		HNOBA	<824..869	CDD:462234	22/44 (50%)
		CYCc	848..1040	CDD:214485	123/191 (64%)