DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and Adcy7

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	411	Identity:	101/411 - (24%)
Similarity:	177/411 - (43%)	Gaps:	101/411 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   883 QLQEEKKKTDALLHEMLPR--------CVADQLKKG-----------HKVDPEHYEQVSIYFSDI 928
            :|:.||::.:.||..:||.        .:.::||:|           |.:..:.::.|||.::||
Mouse   223 KLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKRHQNVSILYADI 287

  Fly   929 VGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIAT 993
            ||||.::::|:|.::|..||:|:..||.|....:..:::.:||.|..|||||: :...||.....
Mouse   288 VGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV-SLPTHARNCVK 351

  Fly   994 MSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPL 1058
            |.|.:..|:.:  :|......:.:|:|||||.|..||:||:..:|.::...|:.|:|||::|||.
Mouse   352 MGLDICEAIKQ--VREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPG 414

  Fly  1059 KIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTY----ERSQR---- 1115
            ::|.:......||:  .|...:       |.|:||..:|     :....|||    .|||:
Mouse   415 RVHITEATLNHLDK--AYEVED-------GHGEQRDPYL-----KEMNIRTYLVIDPRSQQPPPP 465

  Fly  1116 ---------------RGSRALNKFIQ--GTIK-------QAQEQANEYGIRSSLKQKNLPRNSLT 1156
                           |.|..:.::::  |..:       :....::|..|.:..:||.:|.....
Mouse   466 SHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSETPISNGRRQKAIPLRRHR 530

  Fly  1157 RSSSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGS------------------- 1202
            ......|||      |.|.:.   ..||.|..::..:..|.....|
Mouse   531 APDRSASPK------GRLEDD---CDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREY 586

  Fly  1203 -----TQSRYEETTLSLTLSC 1218
                 .::||:....||...|
Mouse   587 RLVPIPRARYDFACASLVFVC 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	7/31 (23%)
		CYCc	886..1078	CDD:214485	66/210 (31%)
		Guanylate_cyc	913..1099	CDD:278633	61/185 (33%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	7/27 (26%)
		Guanylate_cyc	272..422	CDD:306677	53/152 (35%)
		DUF1053	487..593	CDD:399378	16/114 (14%)
		Guanylate_cyc	890..1085	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900