Protein Alignment CG10738 and ADCY8

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001106.1
• Gene: ADCY8 / 114
• HGNCID: 239
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 97/331 - (29%)
• Similarity: 156/331 - (47%)
• Gaps: 49/331 - (14%)

  Fly   868 KYANNLEAL----VDDRTDQLQEEKKKTDALLHEMLPRCVA----DQLKKGHKVDPEHYEQVSIY 924
            :|...|:.|    ..:..::::|.::..:.:|..:||..||    ::.:...::..:.|:.|.:.
Human   920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVM 984

  Fly   925 FSDIVGF------TAMS---AECTPLQVVDFLNDLYTCFDSIIGH---YDVYKVETIGDAYMVVS 977
            |:.|.||      |.|:   .||..|     ||::...||.::|.   .|:.|::|||..||.||
Human   985 FASIPGFADFYSQTEMNNQGVECLRL-----LNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVS 1044

  Fly   978 GLPLRNGDL-----HAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPR 1037
            ||.......     |...:|..||.|..::.|  |.....|...|||||..|.|.|||:|.|.|:
Human  1045 GLSPEKQQCEDKWGHLCALADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQ 1107

  Fly  1038 YCLFGDTVNTASRMESSGVPLKIHCSWQCRQLL-DRLGGYHFAERGVISMKGKGDQ----RTYWL 1097
            |.::|.|||.||||:|:||..:|....:...:| |:  |:.|..||.|.:||..:|    :||:|
Human  1108 YDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQ--GFAFDYRGEIYVKGISEQEGKIKTYFL 1170

  Fly  1098 LGEDEEARTRRTYERSQRR--GSRALNKFIQGTI----KQAQEQANEYGIRSSLKQKNLPRNSLT 1156
            ||..:.    ..:....||  |..:|...:.|.:    :|.|:|.......:.:.:.:..|.:|.
Human  1171 LGRVQP----NPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLL 1231

  Fly  1157 RSSSLE 1162
            ..|..|
Human  1232 SPSGTE 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	9/46 (20%)
		CYCc	886..1078	CDD:214485	70/213 (33%)
		Guanylate_cyc	913..1099	CDD:278633	74/207 (36%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146	1..182
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..92
		AC_N	<161..400	CDD:292831
		CYCc	366..564	CDD:214485
		Guanylate_cyc	405..589	CDD:278633
		DUF1053	617..711	CDD:283888
		CYCc	944..1148	CDD:214485	69/212 (33%)
		Guanylate_cyc	973..1172	CDD:278633	74/207 (36%)
		Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	1109..1251		39/135 (29%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146	1200..1215		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1223..1251		4/15 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900