DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	1208	Identity:	372/1208 - (30%)
Similarity:	550/1208 - (45%)	Gaps:	254/1208 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PCPAPAG------------NYHSGLLHPLLL---LLFLLAFSNFRPTHGEVFTLGYLTASQRRPG 54
            ||..|.|            :..|.:...:||   .|.|.|::.      |.||||.|     .|.
  Rat    25 PCQGPRGLTVRHLRTVSSISVFSVVFWGVLLWADSLSLPAWAR------ETFTLGVL-----GPW 78

  Fly    55 NLDYNRPGLTISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALWTQQVAAYIG 119
            :.|........|.|..|||:.||.......|..|.|.:..| |.:......|.......|||:||
  Rat    79 DCDPIFAQALPSMATQLAVDRVNQDASLLLGSQLDFKILPT-GCDTPHALATFVAHRNTVAAFIG 142

  Fly   120 PQET--CVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQ 182
            |...  |.....:|..:...:.|:.|...: ...|..||.       ..::..:::::..|.|.:
  Rat   143 PVNPGYCPAAALLAQGWGKSLFSWACGAPE-GGGALVPTL-------PSMADVLLSVMRHFGWAR 199

  Fly   183 VSFLYLDDASGQYQPVAETILSTLTDA----GVSIRDIRTWNTIYHHGFMDNPFEALVEQTYA-- 241
            ::.:      ..:|.:..|....|..|    |:.|      ..|...|..:.....:.:|.::
  Rat   200 LAIV------SSHQDIWVTTAQQLATAFRAHGLPI------GLITSLGPGEKGATEVCKQLHSVH 252

  Fly   242 NTRIYLILGHY-----YEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDP---AKPEKYLRGLLLE 298
            ..:|.::..|.     .|...|:...::.|:......|:      .||.   |.|.:....|:|:
  Rat   253 GLKIVVLCMHSALLGGLEQTVLLRCARKEGLTDGRLVFL------PYDTLLFALPYRNRSYLVLD 311

  Fly   299 DVEPLAVQAFQSYLGI-VPTASVSFA---------TFANEVNKYMERPPFNFPNPLGPFGGVKQI 353
            |..||. :|:.:.|.| :.|:..|.|         |.||                |||    :|:
  Rat   312 DDGPLQ-EAYDAVLTISLDTSPESHAFTATKMRGGTAAN----------------LGP----EQV 355

  Fly   354 SAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYR----SAMGYHVYIDENGDAAG 414
            |.....:||||.|.|.||      .....:|:.:..|..|:..|    :.....:.||..|....
  Rat   356 SPLFGTIYDAVILLAHAL------NHSEAHGTGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLP 414

  Fly   415 NYTVLARGSVRNGRNQTVL----------GLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWV 469
            .|.:|.    .||....::          .::|:||.:|                        :.
  Rat   415 QYVILD----TNGEGSQLVPTHILDVSTQQVQPLGTAVH------------------------FP 451

  Fly   470 GGTRPAAAPRCGFG-GEKCVNYTGEISA----------AIAGGAL---LLLSLVSLVLYRNWRYE 520
            ||:.||....|.|. ...|:.....:.:          |:.||.|   :.|.|..|.|.|.
  Rat   452 GGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYFIRLGLQQLRLLRG---- 512

  Fly   521 QELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRL-----PPQSTHPLIRTSQVSLS-- 578
                                          .|.:...|:.|     .|....|.:.:...|.|
  Rat   513 ------------------------------PHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVV 547

  Fly   579 --SNPDADFRYTTIFTP-------IGLYKGQLYAIKK--------VRKKSVDITREMKKELKLLR 626
              .:|.:..:.:|...|       :.||:|:...:||        :|..|:.:.|:|       |
  Rat   548 DGGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKM-------R 605

  Fly   627 DARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS 691
            :.||:|:.||:|....|....::.|:|.||||:|:|.|||::||..|.||::.|:|||:.|||..
  Rat   606 EMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHR 670

  Fly   692 PIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCL----KLLYRAPELLR 752
            ... ||.|.:.||:||:|:|:|:||.|...|.:         .|.|.:..    :||:.||||||
  Rat   671 HFP-HGRLKSRNCVVDTRFVLKITDHGYAEFLE---------SHCSFRPQPAPEELLWTAPELLR 725

  Fly   753 -----QGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSL 812
                 .||..   .|.:||.:|.||:|.|:..|..|:...||:..:.::||..|....   ||.:
  Rat   726 GPRRPWGPGK---ATFKGDVFSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLC---RPLV 784

  Fly   813 QPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALV 877
            .|.:...:|: :.::.||.|.|:|||....|.|:.:.:.:|.:.::.|:|:.|:|||:.:||.||
  Rat   785 SPDQGPLECI-QLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLV 848

  Fly   878 DDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQ 942
            .:||::|:.|::||:.||.:|||..||..||.|..|:||:::||:||||||||||.:||...|::
  Rat   849 QERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIE 913

  Fly   943 VVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKI 1007
            ||.|||||||.||:::..:||||||||||||||.||||.|||:.||||||.|:|.:||....|::
  Rat   914 VVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRM 978

  Fly  1008 RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDR 1072
            ||.|...:.:|.|:||||..||||||.|||||||||||||||||||:|:|.:||.|....|.|..
  Rat   979 RHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLS 1043

  Fly  1073 LG-GYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRT 1109
            |. ||....||...:||||.:.||||.|:....|:..|
  Rat  1044 LDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPT 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	94/439 (21%)
		ANF_receptor	67..416	CDD:279440	80/378 (21%)
		PK_GC-A_B	570..853	CDD:270944	99/310 (32%)
		TyrKc	597..847	CDD:197581	93/266 (35%)
		HNOBA	<862..907	CDD:285003	22/44 (50%)
		CYCc	886..1078	CDD:214485	118/192 (61%)
		Guanylate_cyc	913..1099	CDD:278633	115/186 (62%)
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	92/436 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556		5/26 (19%)
		PK_GC-2D	554..824	CDD:270945	96/293 (33%)
		CYCc	861..1050	CDD:214485	117/188 (62%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		24/40 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820